Výsledky vyhledávání - "James F, Otto"

AbobotulinumtoxinA Versus OnabotulinumtoxinA in Adults with Upper Limb Spasticity: A Randomized, Double-Blind, Crossover Study Protocol

Autor: Pascal Maisonobe, Monica Verduzco-Gutierrez, James F. Otto, Alberto Esquenazi, Ziyad Ayyoub, Atul T. Patel

Publikováno v: Advances in Therapy

Introduction The safety and efficacy of both abobotulinumtoxinA and onabotulinumtoxinA for upper limb spasticity are well established, but head-to-head comparisons are lacking. Methods DIRECTION is an international, randomized, double-blind, crossove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::536ef6e9ecf98c91fc5e2c47f46def3f
http://europepmc.org/articles/PMC8475311

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Electroconvulsive seizure thresholds and kindling acquisition rates are altered in mouse models of humanKCNQ2andKCNQ3mutations for benign familial neonatal convulsions

Autor: Chris Pappas, Mark Leppert, Timothy H. Pruess, E. Jill Dahle, Nanda A. Singh, H. Steve White, Karen S. Wilcox, James F. Otto

Publikováno v: Epilepsia. 50:1752-1759

Summary Purpose: Benign familial neonatal convulsions (BFNC) is caused by mutations in the KCNQ2 and KCNQ3 genes, which encode subunits of the M-type potassium channel. The purpose of this study was to examine the effects of orthologous BFNC-causing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e90acf2cc5b49de25207d7571b9f37e
https://doi.org/10.1111/j.1528-1167.2009.02100.x

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Mouse models of humanKCNQ2andKCNQ3mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization

Autor: James F. Otto, Karen S. Wilcox, Mark Leppert, E. Jill Dahle, Jonathan D. Leslie, Chris Pappas, Jeffrey L. Noebels, H. Steve White, Nanda A. Singh, Alex Vilaythong

Publikováno v: The Journal of Physiology. 586:3405-3423

The childhood epilepsy syndrome of benign familial neonatal convulsions (BFNC) exhibits the remarkable feature of clinical remission within a few weeks of onset and a favourable prognosis, sparing cognitive abilities despite persistent expression of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70b23b59e42321bd614404d7c550e2fb
https://doi.org/10.1113/jphysiol.2008.154971

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A Spontaneous Mutation InvolvingKcnq2(Kv7.2) Reduces M-Current Density and Spike Frequency Adaptation in Mouse CA1 Neurons

Autor: H. Steve White, Yan Yang, James F. Otto, Karen S. Wilcox, Wayne N. Frankel

Publikováno v: The Journal of Neuroscience. 26:2053-2059

The M-type K+current [IK(M)] activates in response to membrane depolarization and regulates neuronal excitability. Mutations in two subunits (KCNQ2 and KCNQ3; Kv7.2 and Kv7.3) that underlie the M-channel cause the human seizure disorder benign famili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72442db33158e3212275d18ccd6c3592
https://doi.org/10.1523/jneurosci.1575-05.2006

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The composition of the GABA receptor at the Caenorhabditis elegans neuromuscular junction

Autor: Janet E. Richmond, Bruce A. Bamber, James F. Otto, Erik M. Jorgensen

Publikováno v: British Journal of Pharmacology. 144:502-509

1 The unc-49 gene of the nematode Caenorhabditis elegans encodes three γ-aminobutyric acid type A (GABAA) receptor subunits. Two of these, UNC-49B and UNC-49C, are expressed at high abundance and co-localize at the neuromuscular junction. 2 The UNC-

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https://doi.org/10.1038/sj.bjp.0706052

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Mice Carrying the Szt1 Mutation Exhibit Increased Seizure Susceptibility and Altered Sensitivity to Compounds Acting at the M-Channel

Autor: James F. Otto, H. Steve White, Yan Yang, Wayne N. Frankel, Karen S. Wilcox

Publikováno v: Epilepsia. 45:1009-1016

Summary: Purpose: Mutations in the genes that encode subunits of the M-type K+ channel (KCNQ2/KCNQ3) and nicotinic acetylcholine receptor (CHRNA4) cause epilepsy in humans. The purpose of this study was to examine the effects of the Szt1 mutation, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba043d4c3307c4bad13c0c20664f7b97
https://doi.org/10.1111/j.0013-9580.2004.65703.x

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Spontaneous deletion of epilepsy gene orthologs in a mutant mouse with a low electroconvulsive threshold

Autor: Yan Yang, Verity A. Letts, Timothy P. O'Brien, Wayne N. Frankel, H. Steve White, Barbara Beyer, James F. Otto

Publikováno v: Human Molecular Genetics. 12:975-984

The electroconvulsive threshold (ECT) test has been used extensively to determine the protection conferred by antiepileptic drug candidates against induced seizures in rodents. Despite its clinical relevance, the potential of ECT to identify mouse ep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be022cffe6e9db328d59fc2665d5a7d
https://doi.org/10.1093/hmg/ddg118

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Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization

Autor: Nanda A, Singh, James F, Otto, E Jill, Dahle, Chris, Pappas, Jonathan D, Leslie, Alex, Vilaythong, Jeffrey L, Noebels, H Steve, White, Karen S, Wilcox, Mark F, Leppert

Publikováno v: The Journal of physiology. 586(14)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a7652cd2e5d3ec894318b6498cf55c84
https://pubmed.ncbi.nlm.nih.gov/18483067

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