Zobrazeno 1 - 10
of 363
pro vyhledávání: '"James F, Martin"'
Autor:
Yaling Dou, Yan Zhang, Logan Rivera, Tingting Hong, Shaohai Fang, Thuy Tien Tran, Yubin Zhou, James F. Martin, Yun Huang
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 6, Pp n/a-n/a (2024)
Abstract Background Myeloid cells play critical roles in the regulation of myocardial injury and repair. Clonal hematopoiesis (CH)‐related mutations in genes, such as Ten‐eleven Translocation 2 (TET2), can impair myeloid cells and are associated
Externí odkaz:
https://doaj.org/article/09a0c5d803c34ffaba37b40f8de2393e
Autor:
Mashrur Ahmed Yafi, Md. Hasibul Husain Hisham, Francisco Grisanti, James F. Martin, Atif Rahman, Md. Abul Hassan Samee
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract A critical challenge of single-cell spatial transcriptomics (sc-ST) technologies is their panel size. Being based on fluorescence in situ hybridization, they are typically limited to panels of about a thousand genes. This constrains research
Externí odkaz:
https://doaj.org/article/5a6db1aa711c4b0fa1cb3075008b7125
Autor:
Yu-Jung Tseng, Yuki Kageyama, Rebecca L. Murdaugh, Ayumi Kitano, Jong Hwan Kim, Kevin A. Hoegenauer, Jonathan Tiessen, Mackenzie H. Smith, Hidetaka Uryu, Koichi Takahashi, James F. Martin, Md Abul Hassan Samee, Daisuke Nakada
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Hematopoietic stem cells (HSCs) are capable of regenerating the blood system, but the instructive cues that direct HSCs to regenerate particular lineages lost to the injury remain elusive. Here, we show that iron is increasingly taken up by
Externí odkaz:
https://doaj.org/article/e2f9fc0f56c34621b4e2cc5d8cfc94a7
Autor:
Tiffany Chern, Annita Achilleos, Xuefei Tong, Matthew C. Hill, Alexander B. Saltzman, Lucas C. Reineke, Arindam Chaudhury, Swapan K. Dasgupta, Yushi Redhead, David Watkins, Joel R. Neilson, Perumal Thiagarajan, Jeremy B. A. Green, Anna Malovannaya, James F. Martin, David S. Rosenblatt, Ross A. Poché
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Combined methylmalonic acidemia (MMA) and hyperhomocysteinemias are inborn errors of vitamin B12 metabolism, and mutations in the transcriptional regulators HCFC1 and RONIN (THAP11) underlie some forms of these disorders. Here the authors generated m
Externí odkaz:
https://doaj.org/article/18e20d90d2e9439192ddff6d1fb4cef0
Autor:
Jeffrey D. Steimle, Francisco J. Grisanti Canozo, Minjun Park, Zachary A. Kadow, Md. Abul Hassan Samee, James F. Martin
Publikováno v:
JCI Insight, Vol 7, Iss 11 (2022)
Atrial fibrillation (AF), the most common sustained cardiac arrhythmia and a major risk factor for stroke, often arises through ectopic electrical impulses derived from the pulmonary veins (PVs). Sequence variants in enhancers controlling expression
Externí odkaz:
https://doaj.org/article/f2e57560ce0e4f0dadfc2264dfb012c0
Autor:
Vivek P. Singh, Jaya P. Pinnamaneni, Aarthi Pugazenthi, Deepthi Sanagasetti, Megumi Mathison, James F. Martin, Jianchang Yang, Todd K. Rosengart
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 24 (2021)
Background The conversion of fibroblasts into induced cardiomyocytes may regenerate myocardial tissue from cardiac scar through in situ cell transdifferentiation. The efficiency transdifferentiation is low, especially for human cells. We explored the
Externí odkaz:
https://doaj.org/article/03a8a14f7f4f4a2bbb8a18395c5c2fe4
Autor:
Antoinette F. van Ouwerkerk, Fernanda M. Bosada, Karel van Duijvenboden, Matthew C. Hill, Lindsey E. Montefiori, Koen T. Scholman, Jia Liu, Antoine A. F. de Vries, Bastiaan J. Boukens, Patrick T. Ellinor, Marie José T. H. Goumans, Igor R. Efimov, Marcelo A. Nobrega, Phil Barnett, James F. Martin, Vincent M. Christoffels
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The majority of disease-associated genetic variants lie in non-coding regions. Here the authors generated and compiled human transcriptomic, epigenomic and chromatin conformation datasets, to identify genes associated with atrial fibrillation and fun
Externí odkaz:
https://doaj.org/article/6c47420fc1c646169658c86522780b7c
Autor:
Shaohai Fang, Jia Li, Yang Xiao, Minjung Lee, Lei Guo, Wei Han, Tingting Li, Matthew C. Hill, Tingting Hong, William Mo, Rang Xu, Ping Zhang, Fen Wang, Jiang Chang, Yubin Zhou, Deqiang Sun, James F. Martin, Yun Huang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Tet-mediated DNA demethylation is intimately involved in reguatling embryonic development. Here the authors characterise DNA methylation and hydroxymethylation dynamics during early cardiac development in both human and mice and provide evidence that
Externí odkaz:
https://doaj.org/article/100780c789c64844afdc6a69f48c6de2
Autor:
Marissa A. Scavuzzo, Matthew C. Hill, Jolanta Chmielowiec, Diane Yang, Jessica Teaw, Kuanwei Sheng, Yuelin Kong, Maria Bettini, Chenghang Zong, James F. Martin, Malgorzata Borowiak
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-21 (2018)
Endocrine progenitors form early in pancreatic development but the diversity of this cell population is unclear. Here, the authors use single cell RNA sequencing of the mouse pancreas at e14.5 and e16.5 to show that endocrine progenitors are temporal
Externí odkaz:
https://doaj.org/article/128732b885f1499aabecf3b2fb56b522
Autor:
Alexander H. Li, Neil A. Hanchard, Dieter Furthner, Susan Fernbach, Mahshid Azamian, Annarita Nicosia, Jill Rosenfeld, Donna Muzny, Lisa C. A. D’Alessandro, Shaine Morris, Shalini Jhangiani, Dhaval R. Parekh, Wayne J. Franklin, Mark Lewin, Jeffrey A. Towbin, Daniel J. Penny, Charles D. Fraser, James F. Martin, Christine Eng, James R. Lupski, Richard A. Gibbs, Eric Boerwinkle, John W. Belmont
Publikováno v:
Genome Medicine, Vol 9, Iss 1, Pp 1-10 (2017)
Abstract Background Left-sided lesions (LSLs) account for an important fraction of severe congenital cardiovascular malformations (CVMs). The genetic contributions to LSLs are complex, and the mutations that cause these malformations span several div
Externí odkaz:
https://doaj.org/article/1959731fdcb748ae9e55ad3d875f098c