Zobrazeno 1 - 10
of 136
pro vyhledávání: '"James F, Lewis"'
Publikováno v:
Expert Review of Respiratory Medicine
The dramatic impact of COVID-19 on humans worldwide has initiated an extraordinary search for effective treatment approaches. One of these is the administration of exogenous surfactant, which is being tested in ongoing clinical trials.Exogenous surfa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d861cbfe96950638b40fe376a8eab8ad
https://doi.org/10.1080/17476348.2021.1865809
https://doi.org/10.1080/17476348.2021.1865809
Publikováno v:
Canadian Respiratory Journal, Vol 4, Iss 1, Pp 21-26 (1997)
Exogenous surfactant administration is currently being tested in patients with the acute respiratory distress syndrome (ARDS). The results of the studies have varied because several factors may influence the host’s response to this therapy. This cl
Externí odkaz:
https://doaj.org/article/625f5504ee294da9a35eeca7a871dc22
Autor:
Li-Juan Yao, Lynda M. McCaig, Annelise E. Barron, Michelle T. Dohm, Lauren A. Broering, Jennifer Lin, James F. Lewis, Ann M. Czyzewski, Ruud A. W. Veldhuizen, Maruti K. Didwania, Nathan J. Brown
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific Reports
Scientific Reports
Acute lung injury (ALI) leads to progressive loss of breathing capacity and hypoxemia, as well as pulmonary surfactant dysfunction. ALI’s pathogenesis and management are complex, and it is a significant cause of morbidity and mortality worldwide. E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e144392f4c807e5dfc500a14f46b02f
https://doaj.org/article/5a096b460ffa43f2a9f1d30deb079393
https://doaj.org/article/5a096b460ffa43f2a9f1d30deb079393
Autor:
Jordan W. Squair, David D.W. Twa, Kirill Zaslavsky, Lynn A Raymond, Alexandra Kuzyk, Mark J Eisenberg, Jennifer X Ji, Ève-Reine Gagné, Norman D. Rosenblum, Xin Wang, Patrick E. Steadman, Ayan K. Dey, James F Lewis, Peter J Margetts, Kent T HayGlass, Michael A. Skinnider, D Alan Underhill
Publikováno v:
CMAJ Open. 5:E308-E314
Background Combined MD/PhD programs provide a structured path for physician-scientist training, but assessment of their success within Canada is limited by a lack of quantitative data. We collected outcomes data for graduates of Canadian MD/PhD progr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f8b23004ba64dd0f8a5caf8bdccf0c0
https://doi.org/10.9778/cmajo.20160152
https://doi.org/10.9778/cmajo.20160152
Fourth Annual Clinician Scientist Trainee Symposium at the Schulich School of Medicine and Dentistry
Publikováno v:
Clinical and investigative medicine. Medecine clinique et experimentale. 42(4)
The Annual Clinician Scientist Trainee Symposium (CSTS) gathers the local medical research community at the Schulich School of Medicine & Dentistry, including research trainees at the medical student, resident and fellow levels. Trainees showcase the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b4038c54e93e6995da120de6551ec9b
https://pubmed.ncbi.nlm.nih.gov/31922709
https://pubmed.ncbi.nlm.nih.gov/31922709
Publikováno v:
Critical Care Medicine. 44:1098-1108
Despite protocols incorporating spontaneous breathing trials, 31% of ICU patients experience difficult or prolonged weaning from mechanical ventilation. Nonfatiguing modes such as pressure support ventilation are recommended. Proportional assist vent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c0a298ffaf20117b4795fc9f4d9e6b
https://doi.org/10.1097/ccm.0000000000001600
https://doi.org/10.1097/ccm.0000000000001600
Autor:
Yuqing Ye, Derek Daniher, James F. Lewis, Ruud A. W. Veldhuizen, Yingliang Ma, Jesse Zhu, Lynda McCaig
Publikováno v:
International Journal of Pharmaceutics. 583:119359
Mechanical ventilation may contribute to the impairment of the pulmonary surfactant system, which is one of the mechanisms leading to the progression of acute lung injury. To investigate the potential protective effects of pulmonary surfactant in a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::958e76b7cde55e1c87f073ae57b39ea1
https://doi.org/10.1016/j.ijpharm.2020.119359
https://doi.org/10.1016/j.ijpharm.2020.119359
Publikováno v:
Clinical and investigative medicine. Medecine clinique et experimentale. 41(1)
Clinician scientists play a critical role in bridging research and clinical practice. Unfortunately, the neglect of research training in medical schools has created clinicians who are unable to translate evidence from literature to practice. Furtherm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e8581921bfb20bf2f32853af2935ce6
https://pubmed.ncbi.nlm.nih.gov/29603690
https://pubmed.ncbi.nlm.nih.gov/29603690
Autor:
Scott Milos, Li-Juan Yao, Cory Yamashita, Yi Y. Zuo, Joshua Qua Hiansen, Lynda McCaig, Brandon J H Banaschewski, Ruud A. W. Veldhuizen, James F. Lewis
Publikováno v:
Biochemistry and Biophysics Reports
Acute respiratory distress syndrome (ARDS) is a pulmonary disorder associated with alterations to the pulmonary surfactant system. Recent studies showed that supra-physiological levels of cholesterol in surfactant contribute to impaired function. Sin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723ad691773141e5cef0ddefbcbc8b2c
https://pubmed.ncbi.nlm.nih.gov/28758151
https://pubmed.ncbi.nlm.nih.gov/28758151
Autor:
James F. Lewis, David W. Holdsworth, Nancy L. Ford, Andrew T. Jeklin, Ruud A. W. Veldhuizen, Maria Drangova, Lynda McCaig
Publikováno v:
Medical Biophysics Publications
Bone and Joint Institute
Physiological Reports
Bone and Joint Institute
Physiological Reports
© 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. In this study, we aim to quantify the differences in lung metrics measured in free-breathin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76b11f16eb5e6e06922e3169fac735ed
https://ir.lib.uwo.ca/biophysicspub/440
https://ir.lib.uwo.ca/biophysicspub/440
