Effects of socioeconomic status on baseline values and outcomes at 24 months in the Treatment of Advanced Glaucoma Study randomised controlled Trial

Autor: Anthony J, King, Jemma, Hudson, Augusto, Azuara-Blanco, James F, Kirwan, Saurabh, Goyal, Kin Sheng, Lim, Graeme, Maclennan, John, Norrie

Publikováno v: The British journal of ophthalmology.

Background/aimsSocioeconomic status (SES) is associated with late disease presentation and poorer outcomes. We evaluate the effect of SES on treatment outcomes and report the correlation between SES and baseline characteristics of participants in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702bd34ee5a787bf272d1c7920c00862
https://pubmed.ncbi.nlm.nih.gov/36596663

Frequency of visual field testing when monitoring patients newly diagnosed with glaucoma: mixed methods and modelling

Autor: David P Crabb, Richard A Russell, Rizwan Malik, Nitin Anand, Helen Baker, Trishal Boodhna, Carol Bronze, Simon SM Fung, David F Garway-Heath, Fiona C Glen, Rodolfo Hernández, James F Kirwan, Claire Lemer, Andrew I McNaught, Ananth C Viswanathan

Publikováno v: Health Services and Delivery Research, Vol 2, Iss 27 (2014)

Background: Visual field (VF) tests are the benchmark for detecting and monitoring the eye disease glaucoma. Measurements from VF tests are variable, which means that frequent monitoring, perhaps over a long period of time, is required to accurately

Externí odkaz: https://doaj.org/article/7685aee10949490c86829053e8f55614

An intraocular pressure polygenic risk score stratifies multiple primary open angle glaucoma parameters including treatment intensity

Autor: Colin E. Willoughby, Helen Griffiths, James F Kirwan, Owen M. Siggs, Xikun Han, Alex W. Hewitt, Robert J Casson, Neeru A. Vallabh, Ashish Agar, John Landers, Geeta Menon, Paul R. Healey, Angela J. Cree, Andrew J. Lotery, N Andrew Frost, Puya Gharahkhani, Stuart MacGregor, Mark M. Hassall, Jamie E Craig, Ayub Qassim, Emmanuelle Souzeau, Anna Galanopoulos, Stuart L. Graham

PURPOSE: To examine the combined effects of common genetic variants associated with intraocular pressure (IOP) on primary open-angle glaucoma (POAG) phenotype using a polygenic risk score (PRS) stratification.DESIGN: Cross-sectional study.PARTICIPANT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb3374a2232b46150302cf8fff8f902
https://eprints.soton.ac.uk/439365/

Developing standards for the development of glaucoma virtual clinics using a modified Delphi approach

Autor: S. Longstaff, Anne Fiona Spencer, Paul J. Foster, James F Kirwan, Aachal Kotecha, James Edwards Morgan, Augusto Azuara-Blanco

Publikováno v: British Journal of Ophthalmology. 102:531-534

PurposeTo obtain consensus opinion for the development of a standards framework for the development and implementation of virtual clinics for glaucoma monitoring in the UK using a modified Delphi methodology.MethodsA modified Delphi technique was use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d52d51594c962eb66ba9c0bead3319d
https://doi.org/10.1136/bjophthalmol-2017-310504

Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma

Autor: Caroline C W Klaver, Xiaoyan Luo, Albert Hofman, Arni B Stefansson, Christopher J Hammond, Fridbert Jonasson, Louis R. Pasquale, Norbert Pfeiffer, Jun Li, Johannes R. Vingerling, Gudmar Thorleifsson, Nicholas G. Martin, René Höhn, Ananth C. Viswanathan, Sarah Ennis, Jonathan L. Haines, Craig E. Pennell, Vesteinn Jonsson, Jessica N. Cooke Bailey, Kathryn P. Burdon, Lennart C. Karssen, Céline Bellenguez, Pirro G. Hysi, Philipp S. Wild, Dominiek D. G. Despriet, James F. Wilson, Cécile Delcourt, Jamie E Craig, Michael A. Hauser, Philippe Amouyel, Leonieke M E van Koolwijk, Andrea Senft, Chiea Chuen Khor, Tien Yin Wong, Tin Aung, Tanja Zeller, Nomdo M. Jansonius, Yik Ying Teo, Yingfeng Zheng, Terri L. Young, David A. Mackey, Brian W Fleck, Roger C. W. Wolfs, Veronique Vitart, Ching-Yu Cheng, Paulus T. V. M. de Jong, Joan E. Bailey-Wilson, Kari Stefansson, Alireza Mirshahi, Lisa S. Kearns, James F Kirwan, Ben A. Oostra, Andrew J. Lotery, Sayoko E. Moroi, Rhys Fogarty, Henriët Springelkamp, R. Rand Allingham, Eranga N. Vithana, Julia E. Richards, André G. Uitterlinden, Wishal D. Ramdas, Cristina Venturini, Paul Leo, Kerrin S. Small, Fernando Rivadeneira, Stuart MacGregor, Jiemin Liao, Karl J. Lackner, Cornelia M. van Duijn, Sandra E Staffieri, Alex W. Hewitt, Hans G Lemij, Seang-Mei Saw, Seyhan Yazar, Janey L. Wiggs, Gabriel Cuellar-Partida, Jae H. Kang, Abhishek Nag, Adriana I Iglesias, Najaf Amin, Tim D. Spector, Claire L. Simpson, Cécilia Maubaret, Robert Wojciechowski, E-Shyong Tai, Liang Xu, Ya Xing Wang, Elisabeth M. van Leeuwen, Ayse Bilge Ozel, Unnur Thorsteinsdottir, Stephanie J. Loomis

Publikováno v: Nature Genetics, 46(10), 1126-1130. Nature Publishing Group
Nature Genetics, 46(10), 1126-1130
Nature genetics, 46(10), 1126-1130. Nature Publishing Group
Nature genetics
Nature Genetics, 46(10), 1126-30. Nature Publishing Group

Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma, and variability in IOP might herald glaucomatous development or progression. We report the results of a genome-wide association study meta-analysis of 18 populati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::168e3aecc686f9a55eaa1e094fb26ae4
https://pure.eur.nl/en/publications/4b859410-3363-4564-9294-9cc3251696e5