Zobrazeno 1 - 10
of 151
pro vyhledávání: '"James F, Collawn"'
Autor:
Jakub Slawski, Maciej Jaśkiewicz, Anna Barton, Sylwia Kozioł, James F. Collawn, Rafał Bartoszewski
Publikováno v:
European Journal of Cell Biology, Vol 103, Iss 2, Pp 151386- (2024)
Hypoxia-inducible factors (HIFs) are transcription factors that reprogram the transcriptome for cells to survive hypoxic insults and oxidative stress. They are important during embryonic development and reprogram the cells to utilize glycolysis when
Externí odkaz:
https://doaj.org/article/a8db4514b4f84c12839ff955b08e8b07
Autor:
Magdalena Gebert, Sylwia Bartoszewska, Lukasz Opalinski, James F. Collawn, Rafał Bartoszewski
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-20 (2023)
Abstract The unfolded protein response is a survival signaling pathway that is induced during various types of ER stress. Here, we determine IRE1’s role in miRNA regulation during ER stress. During induction of ER stress in human bronchial epitheli
Externí odkaz:
https://doaj.org/article/61931b810a8b4da1bd32d89864aa77c0
Autor:
Maciej Jaśkiewicz, Adrianna Moszyńska, Jarosław Króliczewski, Aleksandra Cabaj, Sylwia Bartoszewska, Agata Charzyńska, Magda Gebert, Michał Dąbrowski, James F. Collawn, Rafal Bartoszewski
Publikováno v:
Cellular & Molecular Biology Letters, Vol 27, Iss 1, Pp 1-19 (2022)
Abstract The hypoxia-inducible factors (HIF) are transcription factors that activate the adaptive hypoxic response when oxygen levels are low. The HIF transcriptional program increases oxygen delivery by inducing angiogenesis and by promoting metabol
Externí odkaz:
https://doaj.org/article/75c92cbadd1f4810a08902d147f250fb
Autor:
Maciej Jaśkiewicz, Adrianna Moszyńska, Marcin Serocki, Jarosław Króliczewski, Sylwia Bartoszewska, James F. Collawn, Rafal Bartoszewski
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 21, Pp 454-469 (2022)
The adaptive response to hypoxia involves the transcriptional induction of three transcription factors called hypoxia inducible factor alpha 1, 2 and 3 (HIF-1α, HIF-2α, and HIF-3α) which dimerize with constitutively expressed beta chains that toge
Externí odkaz:
https://doaj.org/article/fe0213f64af444338ce08c32f8a9c6ed
Autor:
Zhang Li, Kurt A. Zimmerman, Sreelakshmi Cherakara, Phillip H. Chumley, James F. Collawn, Jun Wang, Courtney J. Haycraft, Cheng J. Song, Teresa Chacana, Reagan S. Andersen, Mandy J. Croyle, Ernald J. Aloria, Raksha P. Hombal, Isis N. Thomas, Hanan Chweih, Kristin L. Simanyi, James F. George, John M. Parant, Michal Mrug, Bradley K. Yoder
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 1 (2023)
Externí odkaz:
https://doaj.org/article/d33111929bb3477fae3f2ddadac69a61
Publikováno v:
Molecules, Vol 28, Iss 18, p 6740 (2023)
Ubiquitin, a small protein, is well known for tagging target proteins through a cascade of enzymatic reactions that lead to protein degradation. The ubiquitin tag, apart from its signaling role, is paramount in destabilizing the modified protein. Her
Externí odkaz:
https://doaj.org/article/adc426d70d074f188e81f2a5b01d40bd
Publikováno v:
Antioxidants, Vol 12, Iss 8, p 1648 (2023)
Efficient brain function requires as much as 20% of the total oxygen intake to support normal neuronal cell function. This level of oxygen usage, however, leads to the generation of free radicals, and thus can lead to oxidative stress and potentially
Externí odkaz:
https://doaj.org/article/e548d12c86a5479aa65b905d39550336
Autor:
Sylwia Bartoszewska, Jarosław Króliczewski, David K. Crossman, Aneta Pogorzelska, Maciej Bagiński, James F. Collawn, Rafal Bartoszewski
Publikováno v:
Cellular & Molecular Biology Letters, Vol 26, Iss 1, Pp 1-17 (2021)
Abstract Inositol requiring enzyme 1 alpha (IRE1α) is one of three signaling sensors in the unfolding protein response (UPR) that alleviates endoplasmic reticulum (ER) stress in cells and functions to promote cell survival. During conditions of irre
Externí odkaz:
https://doaj.org/article/1879039be587494ea4340a0d41d3eed6
Autor:
Sylwia Bartoszewska, James F. Collawn
Publikováno v:
Cellular & Molecular Biology Letters, Vol 25, Iss 1, Pp 1-20 (2020)
Abstract During hypoxic conditions, cells undergo critical adaptive responses that include the up-regulation of hypoxia-inducible proteins (HIFs) and the induction of the unfolded protein response (UPR). While their induced signaling pathways have ma
Externí odkaz:
https://doaj.org/article/a200896afc384d3b974ad8a051c64483
Autor:
Brittany Butts, PhD, Mustafa I. Ahmed, MD, Navkaranbir S. Bajaj, MD, MPH, Pamela Cox Powell, MS, Betty Pat, PhD, Silvio Litovsky, MD, Himanshu Gupta, MD, Steven G. Lloyd, MD, Thomas S. Denney, PhD, Xiaoxia Zhang, PhD, Inmaculada Aban, PhD, Sakthivel Sadayappan, PhD, MBA, James W. McNamara, PhD, Michael J. Watson, PhD, Carlos M. Ferrario, MD, James F. Collawn, PhD, Clifton Lewis, MD, James E. Davies, MD, Louis J. Dell’Italia, MD
Publikováno v:
JACC: Basic to Translational Science, Vol 5, Iss 2, Pp 109-122 (2020)
Summary: Increasing left atrial (LA) size predicts outcomes in patients with isolated mitral regurgitation (MR). Chymase is plentiful in the human heart and affects extracellular matrix remodeling. Chymase activation correlates to LA fibrosis, LA enl
Externí odkaz:
https://doaj.org/article/8b2e10df0b604a758f656d121b3eff40