Zobrazeno 1 - 10
of 209
pro vyhledávání: '"James F, Amatruda"'
Autor:
John T. Lafin, Cinzia G. Scarpini, Armon Amini, Bendu Konneh, Jeffrey M. Howard, Thomas Gerald, Michelle Nuno, Jin Piao, Anna Savelyeva, Zhaohui Wang, Jeffrey Gagan, Liwei Jia, Cheryl M. Lewis, Sarah Murray, Yun C. Sawa, Vitaly Margulis, Solomon L. Woldu, Douglas W. Strand, Nicholas Coleman, James F. Amatruda, A. Lindsay Frazier, Matthew J. Murray, Aditya Bagrodia
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Circulating miR-371a-3p has excellent performance in the detection of viable (non-teratoma) germ cell tumor (GCT) pre-orchiectomy; however, its ability to detect occult disease is understudied. To refine the serum miR-371a-3p assay in the mi
Externí odkaz:
https://doaj.org/article/8f30f5097b144b91a537ae6cb38b1d83
Autor:
Lin Xu, Joshua L. Pierce, Angelica Sanchez, Kenneth S. Chen, Abhay A. Shukla, Nicholas J. Fustino, Sarai H. Stuart, Aditya Bagrodia, Xue Xiao, Lei Guo, Mark D. Krailo, Furqan Shaikh, Deborah F. Billmire, Farzana Pashankar, Jessica Bestrashniy, J. Wolter Oosterhuis, Ad J. M. Gillis, Yang Xie, Lisa Teot, Jaume Mora, Jenny N. Poynter, Dinesh Rakheja, Leendert H. J. Looijenga, Bruce W. Draper, A. Lindsay Frazier, James F. Amatruda
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Germ cell tumors (GCTs) are neoplasms of the testis, ovary and extragonadal sites that occur in infants, children, adolescents and adults. Post-pubertal (type II) malignant GCTs may present as seminoma, non-seminoma or mixed histologies. In
Externí odkaz:
https://doaj.org/article/7de0ec00eddb4344af90c7a9512816da
Autor:
James F. Amatruda
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 12 (2023)
Externí odkaz:
https://doaj.org/article/93a602c75b9d4e04bfcb0e372c6e24ed
Combined low-pass whole genome and targeted sequencing in liquid biopsies for pediatric solid tumors
Autor:
Eirini Christodoulou, Venkata Yellapantula, Katrina O’Halloran, Liya Xu, Jesse L. Berry, Jennifer A. Cotter, Anya Zdanowicz, Leo Mascarenhas, James F. Amatruda, Dejerianne Ostrow, Moiz Bootwalla, Xiaowu Gai, Fariba Navid, Jaclyn A. Biegel
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-11 (2023)
Abstract We designed a liquid biopsy (LB) platform employing low-pass whole genome sequencing (LP-WGS) and targeted sequencing of cell-free (cf) DNA from plasma to detect genome-wide copy number alterations (CNAs) and gene fusions in pediatric solid
Externí odkaz:
https://doaj.org/article/2d4c69443c07400f8b129c34095fae56
Autor:
Sarah Watson, Collette A. LaVigne, Lin Xu, Didier Surdez, Joanna Cyrta, Delia Calderon, Matthew V. Cannon, Matthew R. Kent, Katherine M. Silvius, Jack P. Kucinski, Emma N. Harrison, Whitney Murchison, Dinesh Rakheja, Franck Tirode, Olivier Delattre, James F. Amatruda, Genevieve C. Kendall
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 112013- (2023)
Summary: Clinical sequencing efforts are rapidly identifying sarcoma gene fusions that lack functional validation. An example is the fusion of transcriptional coactivators, VGLL2-NCOA2, found in infantile rhabdomyosarcoma. To delineate VGLL2-NCOA2 tu
Externí odkaz:
https://doaj.org/article/fdc0828e193b44cf881e6eb5e4a6a484
Autor:
John T. Lafin, Alexander P. Kenigsberg, Xiaosong Meng, Dreaux Abe, Anna Savelyeva, Nirmish Singla, Solomon L. Woldu, Yair Lotan, Ryan J. Mauck, Cheryl M. Lewis, Vitaly Margulis, Daniel Wong, Liwei Jia, Payal Kapur, Lin Xu, Ryan W. Speir, Gregory T. Chesnut, A. Lindsay Frazier, Douglas W. Strand, Nicholas Coleman, Matthew J. Murray, James F. Amatruda, Aditya Bagrodia
Publikováno v:
European Urology Open Science, Vol 26, Iss , Pp 83-87 (2021)
Existing tumor markers for testicular germ cell tumor (TGCT) cannot detect the presence of pure teratoma. Serum miRNAs have strong performance detecting other subtypes of TGCT. Previous reports suggest high levels of miR-375 expression in teratoma ti
Externí odkaz:
https://doaj.org/article/1e906041cff244ba8e0c12744972018d
Publikováno v:
eLife, Vol 11 (2022)
The Ewing sarcoma family of tumors is a group of malignant small round blue cell tumors (SRBCTs) that affect children, adolescents, and young adults. The tumors are characterized by reciprocal chromosomal translocations that generate chimeric fusion
Externí odkaz:
https://doaj.org/article/58e3b2f803f1456eb7be71c47f2d6662
Autor:
Aruna Marchetto, Shunya Ohmura, Martin F. Orth, Maximilian M. L. Knott, Maria V. Colombo, Chiara Arrigoni, Victor Bardinet, David Saucier, Fabienne S. Wehweck, Jing Li, Stefanie Stein, Julia S. Gerke, Michaela C. Baldauf, Julian Musa, Marlene Dallmayer, Laura Romero-Pérez, Tilman L. B. Hölting, James F. Amatruda, Andrea Cossarizza, Anton G. Henssen, Thomas Kirchner, Matteo Moretti, Florencia Cidre-Aranaz, Giuseppina Sannino, Thomas G. P. Grünewald
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Ewing sarcoma is characterized by the fusion of EWSR1 and FLI1. Here, the authors show that EWSR1-FLI1 increases the activity of the developmental transcription factor SOX6, which promotes tumor growth but also increases sensitivity to oxidative stre
Externí odkaz:
https://doaj.org/article/6dc51a99a4e44ac186061ab97fa34c62
Autor:
James F. Amatruda
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 2 (2021)
In the treatment of children and adolescents with cancer, multimodal approaches combining surgery, chemotherapy and radiation can cure most patients, but may cause lifelong health problems in survivors. Current therapies only modestly reflect increas
Externí odkaz:
https://doaj.org/article/5497c86a0ae34ddab7eb1601ed9c9776
Autor:
Lin Xu, Yanbin Zheng, Jing Liu, Dinesh Rakheja, Sydney Singleterry, Theodore W. Laetsch, Jack F. Shern, Javed Khan, Timothy J. Triche, Douglas S. Hawkins, James F. Amatruda, Stephen X. Skapek
Publikováno v:
Cell Reports, Vol 24, Iss 1, Pp 238-251 (2018)
Summary: Identifying oncogenic drivers and tumor suppressors remains a challenge in many forms of cancer, including rhabdomyosarcoma. Anticipating gene expression alterations resulting from DNA copy-number variants to be particularly important, we de
Externí odkaz:
https://doaj.org/article/871c55b5de2a4b92a3c410b2717c5da1