Zobrazeno 1 - 10
of 15
pro vyhledávání: '"James E.N. Minchin"'
Autor:
Loes M.H. Elemans, Iris Pruñonosa Cervera, Susanna E. Riley, Rebecca Wafer, Rosalyn Fong, Panna Tandon, James E.N. Minchin
Publikováno v:
Adipocyte, Vol 8, Iss 1, Pp 330-338 (2019)
Adipose tissues often exhibit subtle, quantitative differences between individuals, leading to a graded series of adiposity phenotypes at the population level. Robust, quantitative analyses are vital for studying these differences. In this Commentary
Externí odkaz:
https://doaj.org/article/fb66fe8b0b184570b40dc7727abd4286
Autor:
Panna Tandon, James E.N. Minchin, Rebecca Wafer, Rosalyn Fong, Iris Pruñonosa Cervera, Loes M.H. Elemans, Susanna E. Riley
Publikováno v:
Adipocyte, Vol 8, Iss 1, Pp 330-338 (2019)
Elemans, L, Prunonosa Cervera, I, Riley, S E, Wafer, R, Fong, R, Tandon, P & Minchin, J 2019, ' Quantitative analyses of adiposity dynamics in zebrafish ', Adipocyte . https://doi.org/10.1080/21623945.2019.1648175
Adipocyte
Elemans, L, Prunonosa Cervera, I, Riley, S E, Wafer, R, Fong, R, Tandon, P & Minchin, J 2019, ' Quantitative analyses of adiposity dynamics in zebrafish ', Adipocyte . https://doi.org/10.1080/21623945.2019.1648175
Adipocyte
Adipose tissues often exhibit subtle, quantitative differences between individuals, leading to a graded series of adiposity phenotypes at the population level. Robust, quantitative analyses are vital for studying these differences. In this Commentary
Autor:
James E.N. Minchin, John F. Rawls, Julia El Sayed Moustafa, Nathan Denton, Fredrik Karpe, Marijana Todorčević, Constantinos Christodoulides, John P. Kemp, Nellie Y. Loh, David M. Evans, Anubha Mahajan, Mark I. McCarthy, Manu Verma, Celia L Gregson, Matt J. Neville, Kerrin S. Small, Katherine E. Pinnick
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Loh, N Y, Minchin, J E N, Pinnick, K E, Verma, M, Todorčević, M, Denton, N, El-Sayed Moustafa, J, P. Kemp, J, Gregson, C L, Evans, D M, Neville, M J, Small, K S, McCarthy, M I, Mahajan, A, Rawls, J F, Karpe, F & Christodoulides, C 2020, ' RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro ', Nature Communications, vol. 11, 2797 . https://doi.org/10.1038/s41467-020-16592-z
Loh, N Y, Minchin, JE, Pinnick, K E, Verma, M, Todorčević, M, Denton, N, El-Sayed Moustafa, J S, Kemp, J P, Gregson, C L, Evans, D, Neville, M J, Small, K S, McCarthy, M I, Mahajan, A, Rawls, J F, Karpe, F & Christodoulides, C 2020, ' RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro ', Nature Communications, vol. (2020) 11, 2797 . https://doi.org/10.1038/s41467-020-16592-z
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Loh, N Y, Minchin, J E N, Pinnick, K E, Verma, M, Todorčević, M, Denton, N, El-Sayed Moustafa, J, P. Kemp, J, Gregson, C L, Evans, D M, Neville, M J, Small, K S, McCarthy, M I, Mahajan, A, Rawls, J F, Karpe, F & Christodoulides, C 2020, ' RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro ', Nature Communications, vol. 11, 2797 . https://doi.org/10.1038/s41467-020-16592-z
Loh, N Y, Minchin, JE, Pinnick, K E, Verma, M, Todorčević, M, Denton, N, El-Sayed Moustafa, J S, Kemp, J P, Gregson, C L, Evans, D, Neville, M J, Small, K S, McCarthy, M I, Mahajan, A, Rawls, J F, Karpe, F & Christodoulides, C 2020, ' RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro ', Nature Communications, vol. (2020) 11, 2797 . https://doi.org/10.1038/s41467-020-16592-z
Fat distribution is an independent cardiometabolic risk factor. However, its molecular and cellular underpinnings remain obscure. Here we demonstrate that two independent GWAS signals at RSPO3, which are associated with increased body mass index-adju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d6f2bebf972c47cc7176712a31a5b32
https://ora.ox.ac.uk/objects/uuid:6cb86e0f-cc0e-4bf5-86d7-da85300193e1
https://ora.ox.ac.uk/objects/uuid:6cb86e0f-cc0e-4bf5-86d7-da85300193e1
Autor:
James E.N. Minchin, John F. Rawls
Publikováno v:
Disease Models & Mechanisms
Disease Models & Mechanisms, Vol 10, Iss 6, Pp 797-809 (2017)
Minchin, J E M & Rawls, J F 2017, ' A classification system for zebrafish adipose tissues ', Disease Models and Mechanisms . https://doi.org/10.1242/dmm.025759
Disease Models & Mechanisms, Vol 10, Iss 6, Pp 797-809 (2017)
Minchin, J E M & Rawls, J F 2017, ' A classification system for zebrafish adipose tissues ', Disease Models and Mechanisms . https://doi.org/10.1242/dmm.025759
The zebrafish model system offers significant utility for in vivo imaging of adipose tissue (AT) dynamics and for screening to identify chemical and genetic modifiers of adiposity. In particular, AT can be quantified accurately in live zebrafish usin
Autor:
James E.N. Minchin
Publikováno v:
Minchin, J E N 2019, ' Adaptation of blind cavefish to nutrient poor environments: uncovering diverse new mechanisms that regulate body fat levels ', Developmental Biology . https://doi.org/10.1016/j.ydbio.2019.01.017
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::871d57ec19d3ed63abc50b77f03796ca
https://hdl.handle.net/20.500.11820/9de36c85-8a36-4f12-9252-d74b794a3673
https://hdl.handle.net/20.500.11820/9de36c85-8a36-4f12-9252-d74b794a3673
Publikováno v:
Tandon, P, Wafer, R & Minchin, J 2018, ' Adipose morphology and metabolic disease ', Journal of Experimental Biology . https://doi.org/10.1242/jeb.164970
Adipose morphology is defined as the number and size distribution of adipocytes (fat cells) within adipose tissue. Adipose tissue with fewer but larger adipocytes is said to have a ‘hypertrophic’ morphology, whereas adipose with many adipocytes o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abdf68a1053268fa87bbf02b33537a90
https://hdl.handle.net/20.500.11820/3c87cfed-077c-4359-b819-87d5dcdb3f17
https://hdl.handle.net/20.500.11820/3c87cfed-077c-4359-b819-87d5dcdb3f17
Autor:
James E.N. Minchin, John F. Rawls
Publikováno v:
Minchin, J E N & Rawls, J F 2017, ' Elucidating the role of plexin D1 in body fat distribution and susceptibility to metabolic disease using a zebrafish model system ', Adipocyte, pp. 1-7 . https://doi.org/10.1080/21623945.2017.1356504
Non-communicable diseases (NCDs) such as cardiovascular disease, diabetes and cancer were responsible for 68% of all deaths worldwide in 2012. The regional distribution of lipid deposited within adipose tissue (AT) - so called body fat distribution (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6681813c53a1e646583091b49baf1ae
https://europepmc.org/articles/PMC5736248/
https://europepmc.org/articles/PMC5736248/
Autor:
John F. Rawls, James E.N. Minchin
Adipose tissues (ATs) are lipid-rich structures that supply and sequester energy-dense lipid in response to the energy status of an organism. As such, ATs provide an organism energetic insurance during periods of adverse physiological burden. ATs are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9cacbc42fe41d3dd2ec39597c304fa9
https://doi.org/10.1016/bs.mcb.2016.11.010
https://doi.org/10.1016/bs.mcb.2016.11.010
Publikováno v:
Endocrinology. 154:1476-1487
Somatic growth and adipogenesis are closely associated with the development of obesity in humans. In this study, we identify a zebrafish mutant, vizzini, that exhibits both a severe defect in somatic growth and increased accumulation of adipose tissu
Autor:
April DeLaurier, Yaniv Hinits, Helen Sang, Petr Valasek, Darrell J. R. Evans, Gavin Brooks, Bodo Christ, Susanne Theis, James E.N. Minchin, Ruijin Huang, Graham Luke, Anthony Otto, Liwen He, Malcolm Logan, Ketan Patel
Publikováno v:
Valasek, P, Theis, S, DeLaurier, A, Hinits, Y, Luke, G N, Otto, A M, Minchin, J, He, L W, Christ, B, Brooks, G, Sang, H, Evans, D J, Logan, M, Huang, R J & Patel, K 2011, ' Cellular and molecular investigations into the development of the pectoral girdle ', Developmental Biology, vol. 357, no. 1, pp. 108-116 . https://doi.org/10.1016/j.ydbio.2011.06.031
The forelimbs of higher vertebrates are composed of two portions: the appendicular region (stylopod, zeugopod and autopod) and the less prominent proximal girdle elements (scapula and clavicle) that brace the limb to the main trunk axis. We show that