Zobrazeno 1 - 10
of 33
pro vyhledávání: '"James E.C. Jepson"'
Publikováno v:
iScience, Vol 23, Iss 2, Pp - (2020)
Summary: Circadian output genes act downstream of the clock to promote rhythmic changes in behavior and physiology, yet their molecular and cellular functions are not well understood. Here we characterize an interaction between regulators of circadia
Externí odkaz:
https://doaj.org/article/76676ba3f0bb4636abe60e2fe348c7dd
Autor:
Roman Praschberger, Simon A. Lowe, Nancy T. Malintan, Carlo N.G. Giachello, Nian Patel, Henry Houlden, Dimitri M. Kullmann, Richard A. Baines, Maria M. Usowicz, Shyam S. Krishnakumar, James J.L. Hodge, James E. Rothman, James E.C. Jepson
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 97-109 (2017)
Mutations in the Golgi SNARE (SNAP [soluble NSF attachment protein] receptor) protein Membrin (encoded by the GOSR2 gene) cause progressive myoclonus epilepsy (PME). Membrin is a ubiquitous and essential protein mediating ER-to-Golgi membrane fusion.
Externí odkaz:
https://doaj.org/article/8d9b11dd09d141658c999a9be32e95ef
Publikováno v:
Neuroscience. 420:41-49
Successive fusion events between transport vesicles and their target membranes mediate trafficking of secreted, membrane- and organelle-localised proteins. During the initial steps of this process, termed the secretory pathway, COPII vesicles bud fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8356e782b759a224196eed86bf98abf
https://doi.org/10.1016/j.neuroscience.2019.03.057
https://doi.org/10.1016/j.neuroscience.2019.03.057
Autor:
James J L Hodge, Edgar Buhl, Dimitri M. Kullmann, Simon Lowe, James E.C. Jepson, Patrick Kratschmer, Alan Pittman, Ko-Fan Chen
Publikováno v:
Kratschmer, P, Lowe, S A, Buhl, E, Chen, K-F, Kullmann, D M, Pittman, A, Hodge, J J L & Jepson, J E C 2021, ' Impaired pre-motor circuit activity and movement in a Drosophila model of KCNMA1-linked dyskinesia ', Movement Disorders, vol. 36, no. 5, pp. 1158-1169 . https://doi.org/10.1002/mds.28479
Movement Disorders
Movement Disorders
Background Paroxysmal dyskinesias (PxDs) are characterized by involuntary movements and altered pre‐motor circuit activity. Causative mutations provide a means to understand the molecular basis of PxDs. Yet in many cases, animal models harboring co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9072c0641ebdde5b853ad64ccdc1a978
https://research-information.bris.ac.uk/en/publications/1c8174e6-e6e0-43b6-885f-978b12fc56c1
https://research-information.bris.ac.uk/en/publications/1c8174e6-e6e0-43b6-885f-978b12fc56c1
Autor:
James E.C. Jepson
Publikováno v:
Curr Biol
Sleep is under homeostatic control, whereby increasing wakefulness generates sleep need and triggers sleep drive. However, the molecular and cellular pathways by which sleep need is encoded are poorly understood. In addition, the mechanisms underlyin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e6029e7695c345e507ec02de0749ba
https://pubmed.ncbi.nlm.nih.gov/33186550
https://pubmed.ncbi.nlm.nih.gov/33186550
Autor:
Simon Lowe, James E.C. Jepson, Edgar Buhl, Patrick Kratschmer, James J L Hodge, Dimitri M. Kullmann, Ko-Fan Chen
BackgroundGenetic and in vitro studies have linked a heterozygous gain-of-function mutation (D434G) in the hSlo1 BK (Big potassium) channel to paroxysmal dyskinesia. However, support for this linkage from in vivo models has been lacking.ObjectivesWe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::863161291b72ccd630d666b3607fa732
https://doi.org/10.1101/2020.02.20.957571
https://doi.org/10.1101/2020.02.20.957571
Publikováno v:
iScience
iScience, Vol 23, Iss 2, Pp-(2020)
iScience, Vol 23, Iss 2, Pp-(2020)
Summary Circadian output genes act downstream of the clock to promote rhythmic changes in behavior and physiology, yet their molecular and cellular functions are not well understood. Here we characterize an interaction between regulators of circadian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba3acffdc5c1d4408c59dcdedc189de5
http://europepmc.org/articles/PMC6997868
http://europepmc.org/articles/PMC6997868
SummaryCircadian output genes act downstream of the clock to promote rhythmic changes in behavior and physiology, yet their molecular and cellular functions are not well understood. Here we characterize an interaction between regulators of circadian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd016cbdd09c01e189e665ffc9c9f9b
Autor:
Claire M. Edwards, Srinivasa R. Rao, James R. Edwards, Patrick Kratschmer, James E.C. Jepson, Sam W. Z. Olechnowicz
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
Experimental biological model system outcomes such as altered animal movement capability or behaviour are difficult to quantify manually. Existing automatic movement tracking devices can be expensive and imposing upon the typical environment of the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f013e89cb15f78e8933b03bddd3b9df7
https://doi.org/10.1038/s41598-019-48841-7
https://doi.org/10.1038/s41598-019-48841-7