Zobrazeno 1 - 10
of 98
pro vyhledávání: '"James E. Vince"'
Autor:
Chaiheon Lee, Mingyu Park, W. C. Bhashini Wijesinghe, Seungjin Na, Chae Gyu Lee, Eunhye Hwang, Gwangsu Yoon, Jeong Kyeong Lee, Deok-Ho Roh, Yoon Hee Kwon, Jihyeon Yang, Sebastian A. Hughes, James E. Vince, Jeong Kon Seo, Duyoung Min, Tae-Hyuk Kwon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Intracellular membranes composing organelles of eukaryotes include membrane proteins playing crucial roles in physiological functions. However, a comprehensive understanding of the cellular responses triggered by intracellular membrane-focus
Externí odkaz:
https://doaj.org/article/0d7766788a7b454e9ef01852b70b934b
Autor:
Daniel Frank, Sarah E. Garnish, Jarrod J. Sandow, Ashley Weir, Lin Liu, Elise Clayer, Lizeth Meza, Maryam Rashidi, Simon A. Cobbold, Simon R. Scutts, Marcel Doerflinger, Holly Anderton, Kate E. Lawlor, Najoua Lalaoui, Andrew J. Kueh, Vik Ven Eng, Rebecca L. Ambrose, Marco J. Herold, Andre L. Samson, Rebecca Feltham, James M. Murphy, Gregor Ebert, Jaclyn S. Pearson, James E. Vince
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104632- (2022)
Summary: Pathogen recognition and TNF receptors signal via receptor interacting serine/threonine kinase-3 (RIPK3) to cause cell death, including MLKL-mediated necroptosis and caspase-8-dependent apoptosis. However, the post-translational control of R
Externí odkaz:
https://doaj.org/article/3caa971ec6024a6691ed27fdce5d0571
Autor:
Swarna L. Vijayaraj, Rebecca Feltham, Maryam Rashidi, Daniel Frank, Zhengyang Liu, Daniel S. Simpson, Gregor Ebert, Angelina Vince, Marco J. Herold, Andrew Kueh, Jaclyn S. Pearson, Laura F. Dagley, James M. Murphy, Andrew I. Webb, Kate E. Lawlor, James E. Vince
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Hyperactivation of inflammasome-induced IL-1β can cause immunopathology and is a feature of autoinflammatory diseases. Here, the authors show how ubiquitination of IL-1β limits its activity by targeting it for proteasomal degradation and preventing
Externí odkaz:
https://doaj.org/article/15cc2871bf48403c8f2afd5582cbe869
Autor:
Karla C. Fischer, Carmel P. Daunt, Cédric S. Tremblay, Sheila Dias, James E. Vince, Anissa M. Jabbour
Publikováno v:
Cell Death and Disease, Vol 12, Iss 1, Pp 1-16 (2021)
Abstract The IκB kinase complex, consisting of IKK1, IKK2 and the regulatory subunit NEMO, is required for NF-κB signalling following the activation of several cell surface receptors, such as members of the Tumour Necrosis Factor Receptor superfami
Externí odkaz:
https://doaj.org/article/349ff71d5e854efda9f9a6fec25d55e3
Autor:
Sarah A. Best, Sheryl Ding, Ariena Kersbergen, Xueyi Dong, Ji-Ying Song, Yi Xie, Boris Reljic, Kaiming Li, James E. Vince, Vivek Rathi, Gavin M. Wright, Matthew E. Ritchie, Kate D. Sutherland
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Lung adenocarcinomas frequently harbour KRAS mutations, of which a subset are characterized by co-mutation of KEAP1. Here the authors show, in mice, that Kras G12D mutant tumours are metabolically distinct, with a bronchiolar cell-of-origin.
Externí odkaz:
https://doaj.org/article/ac2538b3a39145fe917c923569a787a5
Autor:
Kate E. Lawlor, Rebecca Feltham, Monica Yabal, Stephanie A. Conos, Kaiwen W. Chen, Stephanie Ziehe, Carina Graß, Yifan Zhan, Tan A. Nguyen, Cathrine Hall, Angelina J. Vince, Simon M. Chatfield, Damian B. D’Silva, Kenneth C. Pang, Kate Schroder, John Silke, David L. Vaux, Philipp J. Jost, James E. Vince
Publikováno v:
Cell Reports, Vol 20, Iss 3, Pp 668-682 (2017)
X-linked Inhibitor of Apoptosis (XIAP) deficiency predisposes people to pathogen-associated hyperinflammation. Upon XIAP loss, Toll-like receptor (TLR) ligation triggers RIPK3-caspase-8-mediated IL-1β activation and death in myeloid cells. How XIAP
Externí odkaz:
https://doaj.org/article/b2bf45d4cadc4d619c18b1853295fdda
Autor:
Arpeeta Sharma, Mitchel Tate, Geetha Mathew, James E. Vince, Rebecca H. Ritchie, Judy B. de Haan
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
It is now increasingly appreciated that inflammation is not limited to the control of pathogens by the host, but rather that sterile inflammation which occurs in the absence of viral or bacterial pathogens, accompanies numerous disease states, none m
Externí odkaz:
https://doaj.org/article/de3fd9640f974fbd9b1ff6df7d08cf07
Autor:
James M. Murphy, James E. Vince
Publikováno v:
F1000Research, Vol 4 (2015)
Several programmed lytic and necrotic-like cell death mechanisms have now been uncovered, including the recently described receptor interacting protein kinase-3 (RIPK3)-mixed lineage kinase domain-like (MLKL)-dependent necroptosis pathway. Genetic ex
Externí odkaz:
https://doaj.org/article/2e45804ea983441ea306a400552779fb
Autor:
Nathalie Uwamahoro, Jiyoti Verma-Gaur, Hsin-Hui Shen, Yue Qu, Rowena Lewis, Jingxiong Lu, Keith Bambery, Seth L. Masters, James E. Vince, Thomas Naderer, Ana Traven
Publikováno v:
mBio, Vol 5, Iss 2 (2014)
ABSTRACT The fungal pathogen Candida albicans causes macrophage death and escapes, but the molecular mechanisms remained unknown. Here we used live-cell imaging to monitor the interaction of C. albicans with macrophages and show that C. albicans kill
Externí odkaz:
https://doaj.org/article/563581c05a7c464a97fba2d6e6fe6809
Autor:
Gwo Yaw, Ho, Elizabeth L, Kyran, Justin, Bedo, Matthew J, Wakefield, Darren P, Ennis, Hasan B, Mirza, Cassandra J, Vandenberg, Elizabeth, Lieschke, Andrew, Farrell, Anthony, Hadla, Ratana, Lim, Genevieve, Dall, James E, Vince, Ngee Kiat, Chua, Olga, Kondrashova, Rosanna, Upstill-Goddard, Ulla-Maja, Bailey, Suzanne, Dowson, Patricia, Roxburgh, Rosalind M, Glasspool, Gareth, Bryson, Andrew V, Biankin, Susanna L, Cooke, Gayanie, Ratnayake, Orla, McNally, Nadia, Traficante, Anna, DeFazio, S John, Weroha, David D, Bowtell, Iain A, McNeish, Anthony T, Papenfuss, Clare L, Scott, Holly E, Barker
Publikováno v:
Cancer Research. 82:4457-4473
Ovarian carcinosarcoma (OCS) is an aggressive and rare tumor type with limited treatment options. OCS is hypothesized to develop via the combination theory, with a single progenitor resulting in carcinomatous and sarcomatous components, or alternativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5afb9caa5d5f35f4d5f2d0df2b1ae75
https://doi.org/10.1158/0008-5472.can-21-4012
https://doi.org/10.1158/0008-5472.can-21-4012