Zobrazeno 1 - 10
of 17
pro vyhledávání: '"James E. Shields"'
Publikováno v:
Hormone Research. 41:93-96
The Diabetes Control and Complications Trial has emphasized the need for improved control of blood glucose as a means to diminish long-term complications of diabetes. LysPro-insulin is an analog of human insulin whose design was modeled on structural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d3e626c6fb6f1ca1631163b97fc1f2c
https://doi.org/10.1159/000183967
https://doi.org/10.1159/000183967
Autor:
James E. Shields, P L Brown, L K Green, Harlan Beall Long, B. H. Frank, C Bryant, R Millican, A A Miller, David N. Brems, Ronald E. Chance
Publikováno v:
"Protein Engineering, Design and Selection". 5:519-525
Insulin analogs designed to decrease self-association and increase absorption rates from subcutaneous tissue were found to have altered stability. Replacement of HB10 with aspartic acid increased stability while substitutions at B28 and/or B29 were e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d493223a7c3603ca2d3f7c2fc06dce
https://doi.org/10.1093/protein/5.6.519
https://doi.org/10.1093/protein/5.6.519
Autor:
K L Sundell, Jules A. Hoffmann, L J Slieker, Gerald Stephen Brooke, L Fan, Harlan Beall Long, L K Green, Ronald E. Chance, Richard D. DiMarchi, David B. Flora, James E. Shields, P. L. Surface
Publikováno v:
Diabetologia. 40
Inversion of the natural sequence of the B chain of human insulin (HI) from ProB28LysB29 to LysB28ProB29 generates an insulin analogue with reduced tendency to self-associate. Since this substitution increases the homology of insulin to insulin-like
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2a826ed7c01046aa5b2a68eecce6a5
https://pubmed.ncbi.nlm.nih.gov/9248702
https://pubmed.ncbi.nlm.nih.gov/9248702
Publikováno v:
Diabetes. 46(4)
In this study, human insulin was compared with two of its analogs—LysB28ProB29-human insulin and AspB10LysB28ProB29-human insulin—with respect to bioavailability and metabolic effectiveness. Absorption from the subcutaneous site was determined us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::788c1c816cf0e2b02ce29b77b0217a25
https://pubmed.ncbi.nlm.nih.gov/9075793
https://pubmed.ncbi.nlm.nih.gov/9075793
Autor:
L A Alter, B. H. Frank, Richard D. DiMarchi, Allen H. Pekar, Ronald E. Chance, L K Green, David N. Brems, James E. Shields, Harlan Beall Long, M J Beckage
Publikováno v:
Protein engineering. 5(6)
The importance of ProB28 and LysB29 on the self-association of insulin was established by systematically truncating the C terminus of the B chain. The relationship between structure and association was further explored by making numerous amino acid r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b752d63d02f604f05ba25d991f387507
https://pubmed.ncbi.nlm.nih.gov/1438163
https://pubmed.ncbi.nlm.nih.gov/1438163
Autor:
Yesook Kim, James E. Shields
Publikováno v:
Biochemical and biophysical research communications. 186(2)
Zinc insulin hexamer has been shown to undergo a phenol-induced T 6 to R 6 conformational transition in solution. Our circular dichroic (CD) studies demonstrate that insulin undergoes pH-dependent conformational changes over the pH range of 6–10 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276a2e9454ad26a2721585b35461553d
https://pubmed.ncbi.nlm.nih.gov/1497644
https://pubmed.ncbi.nlm.nih.gov/1497644
Publikováno v:
Helvetica Chimica Acta. 64:2587-2591
A new tripeptide, L-α-aminoadipyl-L-seryl-D-valine has been synthesized by coupling the protected L-seryl-D-valine dipeptide with an appropriately protected L-α-aminoadipic acid ester. The free tripeptide was obtained after treatment with liquid HF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bb358de4995c0c1a2a9046076ebd836
https://doi.org/10.1002/hlca.19810640814
https://doi.org/10.1002/hlca.19810640814
Publikováno v:
Helvetica Chimica Acta. 67:870-875
A new tripeptide (dimer), bis[(L-cysteine-S-acetyl)-L-hemicystinyl(S2 S2)-D-valine] (6) was synthesized by coupling N-(tert-butoxycarbonyl)-S-carboxymethyl-L-cysteine benzyl ester (1) with S-trityl-L-cysteinyl-D-valine benzyl ester and subsequent rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28f1766f7efd59e68c22dfef90277d20
https://doi.org/10.1002/hlca.19840670328
https://doi.org/10.1002/hlca.19840670328
Publikováno v:
Journal of Clinical Laboratory Analysis. 1:251-261
Rabbits were immunized with eight chemically synthesized peptides representing sequences of the third and fourth constant domains (Fc fragment) of human IgE to obtain antibodies to predetermined sites on IgE. The peptides, varying in length from 15 t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9bb2ffc9afd70002bf2f09c5d42f9c0
https://doi.org/10.1002/jcla.1860010302
https://doi.org/10.1002/jcla.1860010302
Publikováno v:
The Journal of Organic Chemistry. 26:1491-1494
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2a362a4d09127fb1ee4ae57054101c0
https://doi.org/10.1021/jo01064a043
https://doi.org/10.1021/jo01064a043