Clinical Effects of the Self-administered Subcutaneous Complement Inhibitor Zilucoplan in Patients With Moderate to Severe Generalized Myasthenia Gravis: Results of a Phase 2 Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Trial

Autor: James F, Howard, Richard J, Nowak, Gil I, Wolfe, Miriam L, Freimer, Tuan H, Vu, John L, Hinton, Michael, Benatar, Petra W, Duda, James E, MacDougall, Ramin, Farzaneh-Far, Henry J, Kaminski, Richard, Barohn, Mazen, Dimachkie, Mamatha, Pasnoor, Constantine, Farmakidis, Tina, Liu, Samantha, Colgan, Michael G, Benatar, Tulio, Bertorini, Rekha, Pillai, Robert, Henegar, Mark, Bromberg, Summer, Gibson, Teresa, Janecki, Miriam, Freimer, Bakri, Elsheikh, Paige, Matisak, Angela, Genge, Amanda, Guidon, William, David, Ali A, Habib, Veena, Mathew, Tahseen, Mozaffar, William, Hewitt, Deborah, Barnett, Patricia, Sullivan, Doreen, Ho, Rebecca E, Traub, Manisha, Chopra, Radwa, Aly, Elham, Bayat, Mohammad, Abu-Rub, Shaida, Khan, Dale, Lange, Shara, Holzberg, Bhupendra, Khatri, Emily, Lindman, Tayo, Olapo, Lisa M, Sershon, Robert P, Lisak, Evanthia, Bernitsas, Kelly, Jia, Rabia, Malik, Tiffany D, Lewis-Collins, Michael, Nicolle, Aditi, Sharma, Bhaskar, Roy, Joan, Nye, Michael, Pulley, Alan, Berger, Yasmeen, Shabbir, Amit, Sachdev, Kimberly, Patterson, Zaeem, Siddiqi, Mark, Sivak, Joan, Bratton, George, Small, Anem, Kohli, Mary, Fetter, Tuan, Vu, Lucy, Lam, Brittany, Harvey, Nicholas, Silvestri, Kara, Patrick, Karen, Zakalik, James, MacDougall, Angela, Pontius, Michelle, Hoarty

Publikováno v: JAMA neurology. 77(5)

Importance Many patients with generalized myasthenia gravis (gMG) have substantial clinical disability, persistent disease burden, and adverse effects attributable to chronic immunosuppression. Therefore, there is a significant need for targeted, wel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eeb0f9a4554ca1cd6226b2f14501b70
https://pubmed.ncbi.nlm.nih.gov/32065623

Effect of Linaclotide on Severe Abdominal Symptoms in Patients With Irritable Bowel Syndrome With Constipation

Autor: Caroline B. Kurtz, James E. MacDougall, Eamonn Martin Quigley, Satish S.C. Rao, Jeffrey M. Johnston, Mark G. Currie, Bernard J. Lavins, S J Shiff

Publikováno v: Clinical Gastroenterology and Hepatology. 12:616-623

BACKGROUND & AIMS: Patients with irritable bowel syndrome with constipation (IBS-C) have abdominal symptoms that vary in severity. Linaclotide, a guanylate cyclase-C agonist, improves abdominal and bowel symptoms in these patients. We examined the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd4471dacb105db0d0ca97a65c6790b
https://doi.org/10.1016/j.cgh.2013.09.022

Two Randomized Trials of Linaclotide for Chronic Constipation

Autor: James Z. Shao, Caroline B. Kurtz, Paul Eng, Jeffrey M. Johnston, James E. MacDougall, Harvey Schneier, Bernard J. Lavins, S J Shiff, Susan M. Fox, Donald A. Fitch, Brenda I. Jeglinski, Mark G. Currie, Xinwei D. Jia, Anthony Lembo

Publikováno v: New England Journal of Medicine. 365:527-536

Linaclotide is a minimally absorbed peptide agonist of the guanylate cyclase C receptor. In two trials, we aimed to determine the efficacy and safety of linaclotide in patients with chronic constipation.We conducted two randomized, 12-week, multicent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7435dba23ba7e3629168ae98b8149a8
https://doi.org/10.1056/nejmoa1010863

A method for fitting regression splines with varying polynomial order in the linear mixed model

Autor: Paul W. Stewart, Lloyd J. Edwards, Ronald W. Helms, James E. MacDougall

Publikováno v: Statistics in Medicine. 25:513-527

The linear mixed model has become a widely used tool for longitudinal analysis of continuous variables. The use of regression splines in these models offers the analyst additional flexibility in the formulation of descriptive analyses, exploratory an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a5a62ef86ef59825ee16c6698db2cc0
https://doi.org/10.1002/sim.2232

Gender Differences in the Longitudinal Predictors of Adolescent Dating Violence

Autor: James E. MacDougall, Shrikant I. Bangdiwala, Fletcher Linder, Vangie A. Foshee

Publikováno v: Preventive Medicine. 32:128-141

Background. Adolescent dating violence is a public health problem. The public health approach to prevention is to identify predictors of problem behaviors and develop interventions to eliminate or reduce those predictors with the intention of alterin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed42503c249a535e7a1b88eef52e92c2
https://doi.org/10.1006/pmed.2000.0793