Výsledky vyhledávání - "James E. M. Booker"

Development of a Multikilogram Synthesis of a Chiral Epoxide Precursor to a CCR1 Antagonist. Use of in Situ Monitoring for Informed Optimisation via Fragile Intermediates

Autor: Rhona Sinclair, Nicholas I. Pedge, Christopher J. Sleigh, James E. M. Booker, Edward Way, Marijan Štefinović, Debra Ainge, Luis-Manuel Vaz

Publikováno v: Organic Process Research & Development. 14:72-84

The optimisation and scale up of a manufacturing route to a key intermediate, acetic acid 4-acetylamino-3-(2-methyl-oxiranylmethoxy)phenyl ester (2), utilising a SNAr coupling, the hydrogenation of a nitro moiety and the conversion of a chiral aceton

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8a3861bb03f5999942bc803e6b47dee
https://doi.org/10.1021/op900172t

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Approaches to the quaternary stereocentre and to the heterocyclic core in diazonamide A using the Heck reaction and related coupling reactions

Autor: Alexander J. Blake, James E. M. Booker, Matthew S. Ling, David J. Sinclair, Jaya Prabhakaran, Graham Meek, Alicia Boto, Gerald Pattenden, Gwydion H. Churchill, Clive P. Green

Publikováno v: Organicbiomolecular chemistry. 4(22)

In model studies towards the quaternary centre at the heart of diazonamide A (early structure 2; revised structure 1), cyclisations of the alkene-substituted iodoaryls 4, 13, 18 and 23, under Heck reaction conditions, were shown to lead to the corres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef14e50162685a7c3a57df66e3258f4
https://pubmed.ncbi.nlm.nih.gov/17312976

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