Zobrazeno 1 - 6
of 6
pro vyhledávání: '"James E. Laithwaite"'
Publikováno v:
Infection and Immunity. 67:5827-5833
Cellular intoxification by exotoxin A of Pseudomonas aeruginosa (PEA) begins when PEA binds to its cellular receptor, the low-density lipoprotein receptor-related protein (LRP). This receptor is particularly abundant on macrophages. We hypothesize he
Autor:
Sally J. Benn, James E. Laithwaite, Gordon M. Kirby, Jonathan LaMarre, Yasuhiro Tsukamoto, Jyoji Yamate, Alison Allan
Publikováno v:
Journal of Toxicologic Pathology. 11:219-227
Liver regeneration is accompanied by a series of profound changes in hepatocyte gene expression. Similar changes in gene expression occur when hepatocytes are placed in primary culture. In the present study, we wished to determine the in vitro patter
Autor:
Mika Ide, Sally J. Benn, Alison Allan, Jonathan LaMarre, Takao Kotani, James E. Laithwaite, Mitsuru Kuwamura, Sadashige Sakuma, Masaru Maeda, Jyoji Yamate
Publikováno v:
Toxicologic pathology. 29(4)
Transforming growth factor-beta1 (TGF-beta1) produced by infiltrating macrophages plays a role in fibrotic disorders through the induction of myofibroblasts. To explore possible mechanisms by which TGF-beta1 may act in this context, we investigated e
Autor:
Masaru Maeda, Sally J. Benn, Mitsuru Kuwamura, Jyoji Yamate, James E. Laithwaite, S. Sakuma, Mika Ide, T. Kotani, Jonathan LaMarre, Alison Allan
Publikováno v:
Journal of comparative pathology. 125(1)
Lipopolysaccharide (LPS) is a major modulator of macrophage functions. To characterize a newly established rat histiocytic sarcoma-derived cell line (HS-P), immunophenotypic changes and cellular growth responses of HS-P cells exposed to LPS were inve
Publikováno v:
Toxicon : official journal of the International Society on Toxinology. 39(9)
Pseudomonas exotoxin A (PEA) is an extracellular virulence factor produced by the opportunistic human pathogen Pseudomonas aerguinosa. PEA intoxification begins when PEA binds to the low-density lipoprotein receptor-related protein (LRP). The liver i
Autor:
S. Sakuma, T. Kotani, Mitsuru Kuwamura, Mika Ide, Alison Allan, Masaru Maeda, Yukiko Kannan, Jonathan LaMarre, Sally J. Benn, James E. Laithwaite, Yasuhiro Tsukamoto, Jyoji Yamate
Publikováno v:
Journal of comparative pathology. 124(2-3)
With future exploration of macrophage properties in mind, we established a novel cell line (HS-P) from a transplantable histiocytic sarcoma, derived originally from a tumour in an aged F344 rat. HS-P was subjected to 70 serial passages, in which the