Zobrazeno 1 - 10
of 154
pro vyhledávání: '"James E. Krause"'
Autor:
Harry Brielmann, David J. Matson, Bertrand L. Chenard, Mark T. Kershaw, W. Rycroft, Nicola Burnaby-Davies, Marci Crandall, Stéphane De Lombaert, Kevin J. Hodgetts, William J. Martin, Rajagopal Bakthavatchalam, Beth Ann Murphy, Timothy M. Caldwell, G Mason, A. Brian Jones, Xiaozhang Zheng, Helen Perrett, Susan Boyce, James E. Krause, Daniel N. Cortright, Charles A. Blum, Rachael Conley, Scott M. Capitosti
Publikováno v:
Journal of Medicinal Chemistry. 53:3330-3348
The transient receptor potential cation channel, subfamily V, member 1 (TRPV1) is a nonselective cation channel that can be activated by a wide range of noxious stimuli, including capsaicin, acid, and heat. Blockade of TRPV1 activation by selective a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f2448f051999a0038881eaa30e2452
https://doi.org/10.1021/jm100051g
https://doi.org/10.1021/jm100051g
Publikováno v:
Current Eye Research. 34:57-61
Purpose: We examined the potential for the pro-inflammatory complement proteins C5a and C3a to increase VEGF expression in ARPE-19 cells. Materials and Methods: Expression of complement receptors in ARPE-19 cells was evaluated by RT-PCR. VEGF secreti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e5f0f61b1eedf175c3808445fe2b2e
https://doi.org/10.1080/02713680802546658
https://doi.org/10.1080/02713680802546658
Autor:
Jayaraman Chandrasekhar, Raymond F. Horvath, Ping Ge, Stéphane De Lombaert, Hutchison Alan J, Kevin J. Hodgetts, Dario Doller, Robbin Brodbeck, James E. Krause, Diane Hoffman, Michael Gulianello, Yoon Taeyoung, John H. Kehne
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4486-4490
The design, synthesis and structure-activity relationship studies of a novel series of CRF-1 receptor antagonists, the 2-arylpyrimidines, are described. The effects of substitution on the aromatic ring and the pyrimidine core on CRF-1 receptor bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e03715e3452d8f911694815b9df50eb
https://doi.org/10.1016/j.bmcl.2008.07.063
https://doi.org/10.1016/j.bmcl.2008.07.063
Autor:
Rajagopal Bakthavatchalam, Lawrence K. Fung, Bertrand L. Chenard, David J. Matson, Chu K. Ngo, Marci Crandall, Stéphane De Lombaert, Daniel N. Cortright, Harry Brielmann, Charles A. Blum, Mark T. Kershaw, Jayaraman Chandrasekhar, Marta Day, Xiaozhang Zheng, James E. Krause, Kevin J. Hodgetts
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4573-4577
A focused SAR exploration of the lead 4-aminoquinazoline TRPV1 antagonist 2 led to the discovery of compound 18. In rats, compound 18 is readily absorbed following oral dosing and demonstrates excellent in vivo potency and efficacy in an acute inflam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27714146b399be27941a08e67faa5fd
https://doi.org/10.1016/j.bmcl.2008.07.036
https://doi.org/10.1016/j.bmcl.2008.07.036
Autor:
Diane Hoffman, Ping Ge, Raymond F. Horvath, Kevin J. Hodgetts, Yoon Taeyoung, John H. Kehne, Stéphane De Lombaert, James E. Krause, Michael Gulianello, Mark T. Kershaw, Jayaraman Chandrasekhar, Robbin Brodbeck, Dario Doller
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:891-896
The design, synthesis and structure-activity relationships of a novel series of CRF-1 receptor antagonist, the 1-aryl-4-alkylaminoisoquinolines, is described. The effects of substitution on the aromatic ring, the amino group and the isoquinoline core
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5ebfef8c975699bc46a7324dfc7271
https://doi.org/10.1016/j.bmcl.2007.12.050
https://doi.org/10.1016/j.bmcl.2007.12.050
Autor:
Katrin Stemberger, M. Kralinger, Eduard Schmid, James E. Krause, Josef Troger, Johannes Leierer, Barbara Teuchner, Gertrud Haas, G. F. Kieselbach, Quynh Anh Nguyen, Reiner Fischer-Colbrie
Publikováno v:
Peptides. 27:3370-3376
Very recently, the authors found levels of neurokinin (NK) A-like immunoreactivities in the human retina which were more than five times higher than those of substance P (SP). The present study aimed to find out how many of these immunoreactivities c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb9814864e5c73b6eaac842f83ececd
https://doi.org/10.1016/j.peptides.2006.07.021
https://doi.org/10.1016/j.peptides.2006.07.021
Autor:
S P Sivam, James E. Krause
Publikováno v:
Journal of Neurochemistry. 59:2278-2284
The aim of the study was to test whether the synthesis of substance P (SP) and that of its receptor (also known as NK1 receptor) are coordinately regulated after chronic pharmacologic intervention in two neural systems, the spinal cord and basal gang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da54b7cda01dd75ec0b3f1735174567d
https://doi.org/10.1111/j.1471-4159.1992.tb10121.x
https://doi.org/10.1111/j.1471-4159.1992.tb10121.x
Autor:
Olivier Morteau, James E. Krause, Dubhfeasa M. Slattery, Norma P. Gerard, Alison A. Humbles, Shoji Okinaga, Michele Bennett Kinrade, Robbin Brodbeck, Hyeryun Choe, Zsusanna Zsengeller, Craig Gerard
Publikováno v:
Biochemistry. 42:9406-9415
C5a anaphylatoxin, a potent inflammatory mediator, is known to act through a specific G protein coupled receptor. However, some of the complex effects of C5a in vivo may not be explained solely by the deletion of the known receptor. Here, we show tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b27cb60c7d7b999b37e6c1869d6053f
https://doi.org/10.1021/bi034489v
https://doi.org/10.1021/bi034489v
Autor:
R. Yamamoto, Leah Conroy, J. Lyons, S. Munemitsu, Yasuo Takeda, R. Clark, J. Schreurs, James E. Krause, M. Innis
Publikováno v:
Journal of Neurochemistry. 64:1622-1631
The rat substance P (SP) receptor (SPR) was expressed in insect Sf9 cells by infection with recombinant baculovirus. The receptor bound SP with high affinity (KD = 360 pM) and had a rank order of affinity of SP > neurokinin A > neurokinin B. Ligand a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f87da2cb07cc36e235c9aa4ab6fa5a2f
https://doi.org/10.1046/j.1471-4159.1995.64041622.x
https://doi.org/10.1046/j.1471-4159.1995.64041622.x
Publikováno v:
Journal of Neurochemistry. 64:1183-1191
The substance P (neurokinin-1) receptor belongs to the family of seven putative transmembrane domain receptors that are coupled via G proteins to phospholipase C activation. Homologous desensitization of substance P-stimulated responses has been desc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c10e6d72bb36d3ba8cda7dbc12e0df31
https://doi.org/10.1046/j.1471-4159.1995.64031183.x
https://doi.org/10.1046/j.1471-4159.1995.64031183.x