Zobrazeno 1 - 10
of 133
pro vyhledávání: '"James E. Holden"'
Autor:
Mary L. Schneider, Colleen F. Moore, Elizabeth O. Ahlers, Todd E. Barnhart, Bradley T. Christian, Onofre T. DeJesus, Jonathan W. Engle, James E. Holden, Julie A. Larson, Jeffrey M. Moirano, Dhanabalan Murali, Robert J. Nickles, Leslie M. Resch, Alexander K. Converse
Publikováno v:
Frontiers in Integrative Neuroscience, Vol 13 (2019)
Sensory processing disorder (SPD), a developmental regulatory condition characterized by marked under- or over-responsivity to non-noxious sensory stimulation, is a common but poorly understood disorder that can profoundly affect mood, cognition, soc
Externí odkaz:
https://doaj.org/article/0ee88f22500949c4b25d107fe62e6752
Autor:
Marina E. Emborg, Yan Liu, Jiajie Xi, Xiaoqing Zhang, Yingnan Yin, Jianfeng Lu, Valerie Joers, Christine Swanson, James E. Holden, Su-Chun Zhang
Publikováno v:
Cell Reports, Vol 3, Iss 3, Pp 646-650 (2013)
The generation of induced pluripotent stem cells (iPSCs) opens up the possibility for personalized cell therapy. Here, we show that transplanted autologous rhesus monkey iPSC-derived neural progenitors survive for up to 6 months and differentiate int
Externí odkaz:
https://doaj.org/article/78898b9824044935b1fb1905cb10e4c3
Autor:
James E. Holden, Walter F. Block, Yunlong Tao, Yuejun Chen, Todd E. Barnhart, Viktoriya Bondarenko, Kevin Brunner, Scott C. Vermilyea, Su-Chun Zhang, Lin Yao, Bradley T. Christian, Jeanette M. Metzger, Jianfeng Lu, Nancy Schultz-Darken, Matthew D. Zammit, Sean Phillips, Marina E. Emborg, Miles Olsen, Heather A. Simmons
Publikováno v:
Nature Medicine. 27:632-639
Degeneration of dopamine (DA) neurons in the midbrain underlies the pathogenesis of Parkinson's disease (PD). Supplement of DA via L-DOPA alleviates motor symptoms but does not prevent the progressive loss of DA neurons. A large body of experimental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cfa15c4578a1f05a4193380b86f3f40
https://doi.org/10.1038/s41591-021-01257-1
https://doi.org/10.1038/s41591-021-01257-1
Autor:
Yunlong, Tao, Scott C, Vermilyea, Matthew, Zammit, Jianfeng, Lu, Miles, Olsen, Jeanette M, Metzger, Lin, Yao, Yuejun, Chen, Sean, Phillips, James E, Holden, Viktoriya, Bondarenko, Walter F, Block, Todd E, Barnhart, Nancy, Schultz-Darken, Kevin, Brunner, Heather, Simmons, Bradley T, Christian, Marina E, Emborg, Su-Chun, Zhang
Publikováno v:
Nature medicine. 27(4)
Degeneration of dopamine (DA) neurons in the midbrain underlies the pathogenesis of Parkinson's disease (PD). Supplement of DA via L-DOPA alleviates motor symptoms but does not prevent the progressive loss of DA neurons. A large body of experimental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b72e15d3339771cfb880ad21912bb388
https://pubmed.ncbi.nlm.nih.gov/33798419
https://pubmed.ncbi.nlm.nih.gov/33798419
Autor:
Valerie Joers, Kailie Seneczko, Nichole C Goecks, Timothy J Kamp, Timothy A Hacker, Kevin G Brunner, Jonathan W Engle, Todd E Barnhart, R Jerome Nickles, James E Holden, Marina E Emborg
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35371 (2012)
Parkinson's disease presents nonmotor complications such as autonomic dysfunction that do not respond to traditional anti-parkinsonian therapies. The lack of established preclinical monkey models of Parkinson's disease with cardiac dysfunction hamper
Externí odkaz:
https://doaj.org/article/227a297f5ff0455782ea44e8cdfb6481
Autor:
Kevin Brunner, Catherine L. Gallagher, James E. Holden, R. Jerry Nickles, Viktoriya Bondarenko, Jeanette M. Metzger, Timothy J. Kamp, Patrick J. Lao, Carissa Boettcher, Rachel A. Fleddermann, Colleen F. Moore, Henry Resnikoff, Helen N. Matsoff, Todd E. Barnhart, Bradley T. Christian, Timothy A. Hacker, Marina E. Emborg
Publikováno v:
NPJ Parkinson's Disease
npj Parkinson's Disease, Vol 4, Iss 1, Pp 1-12 (2018)
npj Parkinson's Disease, Vol 4, Iss 1, Pp 1-12 (2018)
Loss of cardiac postganglionic sympathetic innervation is a characteristic pathology of Parkinson’s disease (PD). It progresses over time independently of motor symptoms and is not responsive to typical anti-parkinsonian therapies. Cardiac sympathe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee2a47e603ffe537cf8c0b8dac23808
https://pubmed.ncbi.nlm.nih.gov/30038956
https://pubmed.ncbi.nlm.nih.gov/30038956
Autor:
Sterling C. Johnson, Laura Buyan-Dent, Ozioma C. Okonkwo, Sandra Harding, Jitka Sojkova, Bradley T. Christian, Jen Oh, Brian Bell, Matthew Palotti, Robert J. Nickles, James E. Holden, Charles K. Stone, Catherine L. Gallagher
Publikováno v:
Brain Imaging and Behavior. 9:821-827
Subtle cognitive and behavioral changes are common in early Parkinson's disease. The cause of these symptoms is probably multifactorial but may in part be related to extra-striatal dopamine levels. 6-[(18) F]-Fluoro-L-dopa (FDOPA) positron emission t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599d04ef14ec85e397860d699bafb8ed
https://doi.org/10.1007/s11682-014-9338-4
https://doi.org/10.1007/s11682-014-9338-4
Autor:
Bradley T. Christian, Sandra Harding, James E. Holden, Barbara B. Bendlin, Jen Oh, Onofre T. DeJesus, Clarence T. Li, Charles K. Stone, Catherine L. Gallagher, Matthew Palotti, Robert J. Nickles, Laura Buyan-Dent, Ozioma C. Okonkwo
Publikováno v:
Synapse. 68:325-331
6-[(18)F]-Fluoro-L-dopa (FDOPA) has been widely used as a biomarker for catecholamine synthesis, storage, and metabolism--its intense uptake in the striatum, and fainter uptake in other brain regions, is correlated with the symptoms and pathophysiolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bf6e0f8ead4d57ae464de934badb524
https://doi.org/10.1002/syn.21745
https://doi.org/10.1002/syn.21745
Autor:
James E. Holden, Bradley T. Christian, Julie A. Larson, Alexander K. Converse, Mary L. Schneider, Todd E. Barnhart, Nicholas T. Vandehey, Onofre T. DeJesus, Dhanabalan Murali, Robert J. Nickles
Publikováno v:
Applied Radiation and Isotopes. 72:128-132
A simple synthesis of the dopamine transporter ligand [18F]FECNT with high radiochemical yield and short synthesis time, suitable for routine production is reported. Reaction of 2β-carbomethoxy-3β-(4-chlorophenyl)nortropane with [18F]2-fluoroethyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc7930b832a8acb9425d84646e30b960
https://doi.org/10.1016/j.apradiso.2012.10.010
https://doi.org/10.1016/j.apradiso.2012.10.010
Autor:
James E. Holden, John M. Floberg
Publikováno v:
Physics in Medicine and Biology. 58:1151-1168
We introduce a method for denoising dynamic PET data, spatio-temporal expectation-maximization (STEM) filtering, that combines four-dimensional Gaussian filtering with EM deconvolution. The initial Gaussian filter suppresses noise at a broad range of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9468a087b95e1cb7a610a6a36b2570b6
https://doi.org/10.1088/0031-9155/58/4/1151
https://doi.org/10.1088/0031-9155/58/4/1151