Zobrazeno 1 - 10
of 18
pro vyhledávání: '"James E. Greenwald"'
Publikováno v:
American Journal of Physiology-Renal Physiology. 270:F311-F318
C-type natriuretic peptide (CNP) has been localized to the proximal and distal nephron. In this study, we examined the distribution and regulation of the CNP receptor, guanylyl cyclase type B (GC-B), in the rat kidney. GC-B mRNA was detected most fre
Publikováno v:
Kidney International. 47(6):1569-1575
Zaprinast accelerates recovery from established acute renal failure in the rat. Atrial natriuretic factor (ANF) has been demonstrated to be effective in the treatment of acute renal failure (ARF) in both rat and humans. The biological effects of ANF
Publikováno v:
American Journal of Physiology-Renal Physiology. 263:F974-F978
To date, atrial natriuretic factor (ANF) mRNA has eluded detection in the mammalian kidney, although we and others have identified ANF protein in the kidney using immunohistochemical and immunoassay techniques. Furthermore, we have demonstrated the s
Publikováno v:
Biochemical and Biophysical Research Communications. 188:644-654
Atriopeptin (AP) is synthesized and stored in the mammalian atria as a 126 amino acid prohormone (AP126). Upon secretion, the prohormone undergoes site specific proteolysis within the atria to yield the carboxyl terminal 28 amino acid hormone (AP28).
Publikováno v:
The American journal of physiology. 269(6 Pt 2)
The polarized expression of guanylyl cyclase-coupled natriuretic peptide receptors, types A (GC-A) and B (GC-B), was measured in inner medullary collecting ducts (IMCD) of normal and ischemic rat kidneys, as well as in IMCD cells. Exposure of normal
Publikováno v:
The Journal of biological chemistry. 270(32)
Most agents that regulate osteoclast bone resorption exert their effects indirectly, through the osteoblast. Nitric oxide, which stimulates soluble guanylyl cyclase, has been reported to inhibit osteoclast bone resorption directly, by a cGMP-independ
Publikováno v:
The American journal of physiology. 266(3 Pt 2)
We have previously demonstrated the synthesis of atrial natriuretic factor (ANF) in the distal cortical nephron of the rat kidney. We now report the synthesis of C-type natriuretic peptide (CNP) in the rat, mouse, and human nephron. CNP mRNA was init
Publikováno v:
The American journal of physiology. 263(3 Pt 2)
We recently demonstrated the synthesis and secretion of an atriopeptin (AP)-like prohormone in rat neonatal and adult cortical kidney cell cultures. However, these cultures contained proximal as well as distal tubular epithelial cells; thus character
Publikováno v:
American Journal of Hematology. 11:233-240
Reactive oxygen species, probably hydroxyl radicals (OH.), have been suggested to be generated during arachidonic acid (AA) metabolism and, once released, these species can modify the rate and extent of various reactions involved in AA metabolism. We
Publikováno v:
Proceedings of the National Academy of Sciences. 85:3155-3159
Surgical removal of one or both atrial appendages was employed in rats to reduce the intrinsic stores of atriopeptin (AP). In conscious rats (with intact baroreceptor reflexes), bilateral or unilateral atrial appendectomy suppressed the diuresis and