Zobrazeno 1 - 10
of 28
pro vyhledávání: '"James E. Garrett"'
Autor:
Markus Zweckstetter, Monika Bayrhuber, Michael Ferber, Julita S. Imperial, James E. Garrett, Stefan Becker, Heinrich Terlau, Baldomero M. Olivera, Roland Graf
Publikováno v:
Protein Expression and Purification. 47:640-644
Conkunitzin-S1 from the cone snail Conus striatus is the first member of a new neurotoxin family with a canonical Kunitz domain fold. Conk-S1 is 60 amino acids long and lacks one of the three conserved disulfide bonds typically found in Kunitz domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ab1115492aeb88cc294601c5cb7286
https://doi.org/10.1016/j.pep.2006.01.019
https://doi.org/10.1016/j.pep.2006.01.019
Autor:
Jegannath Korukottu, Baldomero M. Olivera, Heinrich Terlau, Markus Zweckstetter, Julita S. Imperial, Stefan Becker, Vinesh Vijayan, James E. Garrett, Michael Ferber, Monika Bayrhuber, Roland Graf
Publikováno v:
Journal of Biological Chemistry. 280:23766-23770
Conkunitzin-S1 (Conk-S1) is a 60-residue neurotoxin from the venom of the cone snail Conus striatus that interacts with voltage-gated potassium channels. Conk-S1 shares sequence homology with Kunitz-type proteins but contains only two out of the thre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcce4e7173939b44a9b0bd82c9333aab
https://doi.org/10.1074/jbc.c500064200
https://doi.org/10.1074/jbc.c500064200
Autor:
Baldomero M. Olivera, James E. Garrett, Gloria P. Corpuz, Wenqin Li, J. Michael McIntosh, Owen M. McDougal, David R. Hillyard, Clark Colledge, Richard B. Jacobsen, Elsie C. Jimenez, William R. Gray, Lourdes J. Cruz, Craig S. Walker, Jean Rivier, Maren Watkins
Publikováno v:
Biochemistry. 44:8176-8186
Most of the50,000 different pharmacologically active peptides in Conus venoms belong to a small number of gene superfamilies. In this work, the M-conotoxin superfamily is defined using both biochemical and molecular criteria. Novel excitatory peptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48af9662f0a2a0e57b726c1b196f129
https://doi.org/10.1021/bi047541b
https://doi.org/10.1021/bi047541b
Publikováno v:
Biochemical and Biophysical Research Communications. 328:362-367
Each Conus snail species produces 50-200 unique peptide-based conotoxins, derived from a number of different gene superfamilies. Conotoxins are synthesized and secreted in a long venom duct, but biochemical and molecular aspects of their biosynthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3847414777ed8884434fd0dfb5ab8b4a
https://doi.org/10.1016/j.bbrc.2004.12.178
https://doi.org/10.1016/j.bbrc.2004.12.178
Autor:
Alexander Kuryatov, J. Michael McIntosh, Paul Whiteaker, James E. Garrett, Jon Lindstrom, Cheryl Dowell, Layla Azam, Michael J. Marks, Sarah Staheli
Publikováno v:
Molecular Pharmacology. 65:944-952
Neuronal nicotinic acetylcholine receptors (nAChRs) both mediate direct cholinergic synaptic transmission and modulate synaptic transmission by other neurotransmitters. Novel ligands are needed as probes to discriminate among structurally related nAC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6dd35a24a25de3ec8fc21e782f85b50
https://doi.org/10.1124/mol.65.4.944
https://doi.org/10.1124/mol.65.4.944
Autor:
James E. Garrett, Baldomero M. Olivera, Jacob S. Nielsen, Grzegorz Bulaj, Elsie C. Jimenez, Olga Buczek, Ian Goodsell, Jessica Kranski
Publikováno v:
Proceedings of the National Academy of Sciences. 100:14562-14568
The 500 different species of venomous cone snails (genus Conus ) use small, highly structured peptides (conotoxins) for interacting with prey, predators, and competitors. These peptides are produced by translating mRNA from many genes belonging to on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd811e205350131bea86925edf12118b
https://doi.org/10.1073/pnas.2335845100
https://doi.org/10.1073/pnas.2335845100
Autor:
J. Michael McIntosh, Baldomero M. Olivera, Doju Yoshikami, Maren Watkins, James E. Garrett, Cheryl Dowell
Publikováno v:
Journal of Biological Chemistry. 277:33610-33615
Many venomous organisms produce toxins that disrupt neuromuscular communication to paralyze their prey. One common class of such toxins comprises nicotinic acetylcholine receptor antagonists (nAChRs). Thus, most toxins that act on nAChRs are targeted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::577d9572fee0f43bb125d62260ee3911
https://doi.org/10.1074/jbc.m205102200
https://doi.org/10.1074/jbc.m205102200
Autor:
Tyler Keate, Reshma Shetty, Craig S. Walker, James E. Garrett, Pradip K. Bandyopadhyay, Baldomero M. Olivera
Publikováno v:
Proceedings of the National Academy of Sciences. 99:1264-1269
The posttranslational γ-carboxylation of glutamate residues in secreted proteins to γ-carboxyglutamate is carried out by the vitamin K-dependent enzyme γ-glutamyl carboxylase. γ-Carboxylation has long been thought to be a biochemical specializati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a80aafb879632a6b72d1112317ad111
https://doi.org/10.1073/pnas.022637099
https://doi.org/10.1073/pnas.022637099
Autor:
Lance G. Hammerland, Edward F. Nemeth, Forrest H. Fuller, Irene V. Capuano, Steven C. Hebert, Benjamin C. P. Hung, James E. Garrett, Edward M. Brown
Publikováno v:
Journal of Biological Chemistry. 270:12919-12925
Parathyroid cells express a cell surface receptor, coupled to the mobilization of intracellular Ca2+, that is activated by increases in the concentration of extracellular Ca2+ and by a variety of other cations. This "Ca2+ receptor" (CaR) serves as th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57318e51f2e124385468ea659c418c68
https://doi.org/10.1074/jbc.270.21.12919
https://doi.org/10.1074/jbc.270.21.12919
Autor:
James E. Garrett
Publikováno v:
International Journal of Public Administration. 16:1247-1263
Professional social workers in both macro and micro settings are vitally concerned with public policy, particularly that of social welfare policy, and its implementation. They are keenly aware of t...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2df51dd12ae20eff626403c606cd280
https://doi.org/10.1080/01900699308524845
https://doi.org/10.1080/01900699308524845