Zobrazeno 1 - 10
of 25
pro vyhledávání: '"James E. Fortney"'
Autor:
Stephanie L Rellick, Heather O'Leary, Debbie Piktel, Cheryl Walton, James E Fortney, Stephen M Akers, Karen H Martin, James Denvir, Goran Boskovic, Donald A Primerano, Jeffrey Vos, Nathanael Bailey, Marieta Gencheva, Laura F Gibson
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30758 (2012)
Hematopoietic reconstitution, following bone marrow or stem cell transplantation, requires a microenvironment niche capable of supporting both immature progenitors and stem cells with the capacity to differentiate and expand. Osteoblasts comprise one
Externí odkaz:
https://doaj.org/article/aa83f367457448d29e2aff0cf4282d0f
Autor:
Rebecca Evans, Laura F. Gibson, James E. Fortney, Blake S. Moses, Ian Hare, Debbie Piktel, Will Slone
Publikováno v:
Medical oncology (Northwood, London, England). 33(10)
Mesenchymal stem cells (MSCs) are abundant throughout the body and regulate signaling within tumor microenvironments. Wnt signaling is an extrinsically regulated pathway that has been shown to regulate tumorigenesis in many types of cancer. After eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b10a39f5d322d3d6abff0b667dc349
https://pubmed.ncbi.nlm.nih.gov/27586146
https://pubmed.ncbi.nlm.nih.gov/27586146
Autor:
Jeffrey A. Vos, James E. Fortney, Debbie Piktel, David M. Howell, Ian Hare, Laura F. Gibson, Rebecca Evans, Marieta Gencheva
Publikováno v:
Stem Cells International, Vol 2016 (2016)
Stem Cells International
Stem Cells International
Mesenchymal stem cells (MSCs) are of interest for use in diverse cellular therapies.Ex vivoexpansion of MSCs intended for transplantation must result in generation of cells that maintain fidelity of critical functions. Previous investigations have id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6926190757a13f7253517585ae3555
Publikováno v:
Journal of Cardiovascular Translational Research. 3:625-634
Extracorporeal membrane oxygenation (ECMO) is routinely used to support cardiopulmonary failure in infants and children. Suboptimal outcomes for primary cardiac support suggest a need for investigation of the impact of ECMO on the heart. Twenty-four
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e49e1bfd2ad5f9c85bf9d397f1f9903e
https://doi.org/10.1007/s12265-010-9215-5
https://doi.org/10.1007/s12265-010-9215-5
Autor:
Karen H. Martin, James E. Coad, Cheryl Walton, James E. Fortney, Stephen M. Akers, Heather O'Leary, Debra Piktel, Michael Craig, Laura F. Gibson
Publikováno v:
Cancer Microenvironment. 3:67-81
The mechanisms by which the bone marrow microenvironment regulates tumor cell survival are diverse. This study describes the novel observation that in addition to Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL) cell lines, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed37d98e8a920420786c2da47bcabf5
https://doi.org/10.1007/s12307-010-0035-6
https://doi.org/10.1007/s12307-010-0035-6
Publikováno v:
Experimental Hematology. 34:1522-1531
Objective Bone marrow stromal cell function is a critical influence on hematopoietic reconstitution following progenitor or stem cell transplantation. Stromal cells support hematopoietic cell migration, survival, and proliferation. We have previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2770e08c0b25d4fa6590d9242e499190
https://doi.org/10.1016/j.exphem.2006.06.021
https://doi.org/10.1016/j.exphem.2006.06.021
Publikováno v:
Leukemia Research. 28:733-742
Several studies document ALL cell response to survival signals from bone marrow stromal cells. The current study suggests a requirement for active Akt in ALL cells for optimal stromal cell protection during chemotherapy. ALL cells expressing dominant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f92361e16761d2ce0667789fb2c37f
https://doi.org/10.1016/j.leukres.2003.10.033
https://doi.org/10.1016/j.leukres.2003.10.033
Publikováno v:
Leukemia & Lymphoma. 43:2171-2178
Bcl-2 is the major anti-apoptotic protein evaluated in studies aimed at understanding programmed cell death. Recent work suggests that the biological activity of Bcl-2 is modulated by proteolytic cleavage, with a 23 kDa cleaved Bcl-2 product having p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f42390e2e3de1ef4de568ec951cf895
https://doi.org/10.1080/1042819021000033024
https://doi.org/10.1080/1042819021000033024
Publikováno v:
Biochemical Pharmacology. 61:1243-1252
Bone marrow stromal cells are an essential regulatory component in the hematopoietic microenvironment. Regulation of hematopoietic cell development is mediated, in part, through interaction of progenitor cells with stromal cell vascular cell adhesion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41cf4e7cdbfcf6f7edd42414cebd668a
https://doi.org/10.1016/s0006-2952(01)00602-5
https://doi.org/10.1016/s0006-2952(01)00602-5
Publikováno v:
Blood. 96:1926-1932
Approximately 20% of B-lineage acute lymphoblastic leukemias are not cured by traditional chemotherapy. The possibility was examined that residual leukemic cells that potentially contribute to relapse are harbored in association with fibroblastic str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5296cc9e6d645b9e30510b75e60f81
https://doi.org/10.1182/blood.v96.5.1926
https://doi.org/10.1182/blood.v96.5.1926