Zobrazeno 1 - 10
of 16
pro vyhledávání: '"James E. Finley"'
Autor:
Christine P. Bono, Mazin Derzi, Lindsay Tomlinson, Bart Jessen, Anna K. Kopec, James E. Finley, Ikuo Horii, John E. Burkhardt, Shuyan Lu, Carol B. Donovan, Julie Harney, Mark Collinge, Andrew D. Burdick, Ryuji Yokokawa, Ramin Banan Sadeghian, Nasir K. Khan, Jessica Roy
Publikováno v:
The Journal of toxicological sciences. 46(3)
Microphysiological systems (MPS) are making advances to provide more standardized and predictive physiologically relevant responses to test articles in living tissues and organ systems. The excitement surrounding the potential of MPS to better predic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f9e5347e752a79f1985fa87509e7116
https://pubmed.ncbi.nlm.nih.gov/33642521
https://pubmed.ncbi.nlm.nih.gov/33642521
Autor:
Ariana Hirsh, Robert Dullea, Meihua Tu, Spiros Liras, Joan Compte Barrón, Kris A. Borzilleri, Nannan Ma, Rima Mendonsa, Justin Bellenger, Romain Rouet, Lorena de Oñate, Xidong Feng, Jennifer A. Doudna, Nathanael G. Lintner, David M. Rubitski, Benjamin A. Thuma, Marc D. Roy, Alison H. Varghese, Kim F. McClure, Ross C. Wilson, Thomas J. McLellan, Hanna M. Wisniewska, James E. Finley, Boris A. Chrunyk, Vincent Mascitti, Kaihong Zhou, Kevin D. Hesp
Publikováno v:
Journal of the American Chemical Society, vol 140, iss 21
Rouet, Romain; Thuma, Benjamin A; Roy, Marc D; Lintner, Nathanael G; Rubitski, David M; Finley, James E; et al.(2018). Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing.. Journal of the American Chemical Society, 140(21), 6596-6603. doi: 10.1021/jacs.8b01551. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/61k3t664
Rouet, Romain; Thuma, Benjamin A; Roy, Marc D; Lintner, Nathanael G; Rubitski, David M; Finley, James E; et al.(2018). Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing.. Journal of the American Chemical Society, 140(21), 6596-6603. doi: 10.1021/jacs.8b01551. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/61k3t664
CRISPR-Cas RNA-guided endonucleases hold great promise for disrupting or correcting genomic sequences through site-specific DNA cleavage and repair. However, the lack of methods for cell- and tissue-selective delivery currently limits both research a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af967c5dc058dcd0e0a6cfe05eb8b81
https://doi.org/10.1021/jacs.8b01551
https://doi.org/10.1021/jacs.8b01551
Autor:
James E. Finley, Germaine Boucher, Thomas A. Lanz, Julie Harney, Colleen M. Doshna, Anna K. Kopec, Petra H. Koza-Taylor, Karissa Adkins, Piyush Bajaj, Christopher Somps, Christopher Houle
Publikováno v:
Toxicology in Vitro. 70:105012
Alveolar type II (ATII) epithelial cells contain lamellar bodies (LBs) which synthesize and store lung surfactants. In animals, the inhibition or knockout of leucine-rich repeat kinase 2 (LRRK2) causes abnormal enlargement of LBs in ATII cells. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e28a686118e0dbe35dacd473e3b9bf
https://doi.org/10.1016/j.tiv.2020.105012
https://doi.org/10.1016/j.tiv.2020.105012
Autor:
Robert Dullea, Kris A. Borzilleri, Romain Rouet, Vincent Mascitti, Ross C. Wilson, Boris A. Chrunyk, Ariana Hirsh, Benjamin A. Thuma, Xidong Feng, Jennifer A. Doudna, Hanna M. Wisniewska, Spiros Liras, Thomas J. McLellan, Kaihong Zhou, Kim F. McClure, James E. Finley, Joan Compte Barrón, Kevin D. Hesp, Meihua Tu, David M. Rubitski, Lorena de Oñate, Alison H. Varghese, Rima Mendonsa, Nannan Ma, Justin Bellenger, Marc D. Roy, Nathanael G. Lintner
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f270393f8db883382554c04a0d34fe48
https://doi.org/10.1096/fasebj.2018.32.1_supplement.649.2
https://doi.org/10.1096/fasebj.2018.32.1_supplement.649.2
Autor:
Boris A. Chrunyk, Vincent Mascitti, Michael M. Baksh, Robert Dullea, Marc D. Roy, David Price, Cathy Préville, Carlos A. Sanhueza, Wen Lin, Elnaz Menhaji-Klotz, Meihua Tu, Amanda King-Ahmad, David F. Gebhard, Benjamin A. Thuma, Mark Ammirati, James E. Finley, Christopher T. Salatto, Spiros Liras, Sanjay Dutta, Shenping Liu, Benjamin Reidich, Kevin Beaumont, Ingrid A. Stock, Karen Atkinson, Rajesh Kumar, M. G. Finn
Publikováno v:
Journal of the American Chemical Society. 139(9)
A compact and stable bicyclic bridged ketal was developed as a ligand for the asialoglycoprotein receptor (ASGPR). This compound showed excellent ligand efficiency, and the molecular details of binding were revealed by the first X-ray crystal structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960308770c3c39141859f247dd5ef639
https://pubmed.ncbi.nlm.nih.gov/28230359
https://pubmed.ncbi.nlm.nih.gov/28230359
Autor:
Edmund I. Graziani, Xiaotian Zhong, Chethana Kulkarni, Andrew J. Bessire, James E. Finley, Sylvia Musto
Publikováno v:
Bioconjugate chemistry. 28(4)
As the antibody-drug conjugate (ADC) field grows increasingly important for cancer treatment, it is vital for researchers to establish a firm understanding of how ADCs function at the molecular level. To gain insight into ADC uptake, trafficking, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f38f327164c04860c9dcfb57a8b0b7
https://pubmed.ncbi.nlm.nih.gov/28191936
https://pubmed.ncbi.nlm.nih.gov/28191936
Autor:
Douglas E. Wood, Robert B. Nelson, Barbara G. Sahagan, Xingrong Liu, Lei Zhang, Nikolay Pozdnyakov, Jeffrey Van Deusen, Karl E.G. Richter, James E. Finley, Christine P. Parker, Karen J. Coffman, Michael Aaron Brodney, Barbara-Anne Martin, David D. Auperin, Joel B. Schachter, Dane R. Liston, Michael J. Karmilowicz, Tracy M. Brown, Barbara Tate, Christine E. Oborski, Sharon A. Sokolowski, Stacey L. Becker, Bronk Brian Scott, Thomas A. Lanz, Carol D. Hicks, Charles E. Nolan, Kathleen M. Wood
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2637-2640
A novel series of tetralin containing amino imidazoles, derived from modification of the corresponding phenyl acetic acid derivatives is described. Replacement of the amide led to identification of a potent series of tetralin-amino imidazoles with ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecedc3d6dd0ae90f3f64245736a002bc
https://doi.org/10.1016/j.bmcl.2010.12.118
https://doi.org/10.1016/j.bmcl.2010.12.118
Autor:
Kathleen M. Wood, Ping Du, Karen J. Coffman, Karl E.G. Richter, Sharon A. Sokolowski, Barbara-Anne Martin, Dane R. Liston, Barbara Tate, Douglas E. Wood, Tracy M. Brown, Michael Aaron Brodney, Carol D. Hicks, Charles E. Nolan, Nikolay Pozdnyakov, James E. Finley, Christine E. Oborski, Stacey L. Becker, Thomas A. Lanz, Kieran F. Geoghegan
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 334:269-277
PF-3084014 [(S)-2-((S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-3-ylamino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide] is a novel gamma-secretase inhibitor that reduces amyloid-beta (Abeta) production with an in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe3da18b952deeed900e3aece6d23d62
https://doi.org/10.1124/jpet.110.167379
https://doi.org/10.1124/jpet.110.167379
Autor:
Nikolay Pozdnyakov, Karen J. Coffman, Bronk Brian Scott, Douglas E. Wood, Xingrong Liu, Karl E.G. Richter, Dane R. Liston, James E. Finley, Sharon A. Sokolowski, Barbara Tate, Thomas A. Lanz, Michael Aaron Brodney, Christine E. Oborski, Jeffrey Van Deusen, Stacey L. Becker, Carol D. Hicks, Charles E. Nolan, Kathleen M. Wood, Michael J. Karmilowicz, Barbara-Anne Martin, Joel B. Schachter, Christine P. Parker, Robert B. Nelson, David D. Auperin, Barbara G. Sahagan, Tracy M. Brown
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(9)
The synthesis and structure–activity relationship (SAR) of a novel series of di-substituted imidazoles, derived from modification of DAPT, are described. Subsequent optimization led to identification of a highly potent series of inhibitors that con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf5ef01d39846e8c2950263ae44f3e4b
https://pubmed.ncbi.nlm.nih.gov/21269825
https://pubmed.ncbi.nlm.nih.gov/21269825
Autor:
Stacey L. Becker, Kathleen M. Wood, Robin J. Kleiman, Abigail Mariga, Diane Stephenson, Susan E. Bove, Frederick R. Nelson, Thomas A. Lanz, Mark J. Majchrzak, Patricia A. Seymour, Patrick Robert Verhoest, Santos Carvajal-Gonzales, A. Max Kuhn, James E. Finley
Publikováno v:
Alzheimer's & Dementia. 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f4a980342bc27919c07b821e3a07903
https://doi.org/10.1016/j.jalz.2010.05.1922
https://doi.org/10.1016/j.jalz.2010.05.1922