Zobrazeno 1 - 10
of 19
pro vyhledávání: '"James E. DiCarlo"'
Autor:
Zoe F. Weiss, James E. DiCarlo, David W. Basta, Stephanie Kent, Alexis Liakos, Lindsey Baden, Manfred Brigl, Sanjat Kanjilal, Connie Cañete-Gibas, Nathan P. Wiederhold, Sankha S. Basu
Publikováno v:
Annals of Clinical Microbiology and Antimicrobials, Vol 21, Iss 1, Pp 1-6 (2022)
Abstract Cryptococcuria is a rare manifestation of localized cryptococcal disease. We present a case of Cryptococcus neoformans urinary tract infection in an immunocompromised host missed by routine laboratory workup. The patient had negative blood c
Externí odkaz:
https://doaj.org/article/49ad3c04a2974e0aa479da4142f622cd
Autor:
Ryan S. Dhindsa, Quanli Wang, Dimitrios Vitsios, Oliver S. Burren, Fengyuan Hu, James E. DiCarlo, Leonid Kruglyak, Daniel G. MacArthur, Matthew E. Hurles, Slavé Petrovski
Publikováno v:
Am J Hum Genet
SummarySynonymous mutations change the DNA sequence of a gene without affecting the amino acid sequence of the encoded protein. Although emerging evidence suggests that synonymous mutations can impact RNA splicing, translational efficiency, and mRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::866ec13855c8cacd54b3922e55dbbc8c
https://doi.org/10.1101/2022.07.13.499964
https://doi.org/10.1101/2022.07.13.499964
Autor:
Xiaoli Xu, Guisheng Zeng, Meagan Hamblin, Yue Wang, Rebecca S. Shapiro, James E. DiCarlo, Alexey V. Revtovich, Caroline B. M. Porter, Christian Schrøder Kaas, George M. Church, Natalia V. Kirienko, James J. Collins, Alejandro Chavez
Publikováno v:
Nature microbiology
Candida albicans is the leading cause of fungal infections; yet, complex genetic interaction analysis remains cumbersome in this diploid pathogen. Here, we developed a CRISPR-Cas9-based ‘gene drive array’ (GDA) platform to facilitate efficient ge
Publikováno v:
Nature biotechnology
RNA-guided gene drives capable of spreading genomic alterations made in laboratory organisms through wild populations in an inheritable way could be used to control populations of organisms that cause environmental and public health problems. However
Publikováno v:
The Journal of clinical investigation. 128(6)
Precision medicine seeks to treat disease with molecular specificity. Advances in genome sequence analysis, gene delivery, and genome surgery have allowed clinician-scientists to treat genetic conditions at the level of their pathology. As a result,
Publikováno v:
Advances in experimental medicine and biology. 1016
Over the past few decades the ability to edit human cells has revolutionized modern biology and medicine. With advances in genome editing methodologies, gene delivery and cell-based therapeutics targeted at treatment of genetic disease have become a
Autor:
Marcus A. Toral, MaryAnn Mahajan, Thiago Cabral, Vinit B. Mahajan, James E. DiCarlo, Gabriel Velez, Anuradha Gore, Alexander G. Bassuk, Stephen H. Tsang
Publikováno v:
Journal of Visualized Experiments.
The human retina is composed of the sensory neuroretina and the underlying retinal pigmented epithelium (RPE), which is firmly complexed to the vascular choroid layer. Different regions of the retina are anatomically and molecularly distinct, facilit
Autor:
Ryan Cecchi, Christian Schrøder Kaas, Santiago Lopez Garnier, Yingleong Chan, Xiaoge Guo, George M. Church, Alejandro Chavez, Angela Tung, James J. Collins, James E. DiCarlo, Eric D. Kelsic, Max G. Schubert
Construction of genetic variant libraries with phenotypic measurement is central to advancing today’s functional genomics, and remains a grand challenge. Here, we introduce a Cas9-based approach for generating pools of mutants with defined genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785fd2e95c21fbe0b990a36013742124
https://doi.org/10.1101/195776
https://doi.org/10.1101/195776
Autor:
Xiaoge Guo, James J. Collins, Angela Tung, George M. Church, Ryan J Cecchi, Christian Schrøder Kaas, Yingleong Chan, Yi Yin, James E. DiCarlo, Max G. Schubert, Eric D. Kelsic, Alejandro Chavez, Santiago Lopez Garnier
Publikováno v:
Nature biotechnology
Construction and characterization of large genetic variant libraries is essential for understanding genome function, but remains challenging. Here, we introduce a Cas9-based approach for generating pools of mutants with defined genetic alterations (d
Autor:
Leslie A. Mitchell, Jef D. Boeke, Cheng Lai Victor Huang, Dongwon Lee, Sarah M. Richardson, Joel S. Bader, Giovanni Stracquadanio, Jessica S. Dymond, Kun Yang, Yizhi Cai, Srinivasan Chandrasegaran, James E. DiCarlo
Publikováno v:
Richardson, S M, Mitchell, L A, Stracquadanio, G, Yang, K, Dymond, J S, DiCarlo, J E, Lee, D, Huang, C L V, Chandrasegaran, S, Cai, Y, Boeke, J D & Bader, J S 2017, ' Design of a synthetic yeast genome ', Science, vol. 355, no. 6329, pp. 1040-1044 . https://doi.org/10.1126/science.aaf4557
We describe complete design of a synthetic eukaryotic genome, Sc2.0, a highly modified Saccharomyces cerevisiae genome reduced in size by nearly 8%, with 1.1 megabases of the synthetic genome deleted, inserted, or altered. Sc2.0 chromosome design was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c29df8dbe7906cc7992b80324b38cf
https://doi.org/10.1126/science.aaf4557
https://doi.org/10.1126/science.aaf4557