Zobrazeno 1 - 10
of 19
pro vyhledávání: '"James E. Dennison"'
Autor:
James E. Dennison, Melvin E. Andersen, Ivan D. Dobrev, Raymond S. H. Yang, Philip Bigelow, Moiz Mumtaz
Publikováno v:
Journal of Occupational and Environmental Hygiene. 2:127-135
Under OSHA and American Conference of Governmental Industrial Hygienists (ACGIH) guidelines, the mixture formula (unity calculation) provides a method for evaluating exposures to mixtures of chemicals that cause similar toxicities. According to the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4c5eef96a542e4782626869640331c6
https://doi.org/10.1080/15459620590916198
https://doi.org/10.1080/15459620590916198
Publikováno v:
Environmental Science & Technology. 38:5674-5681
Physiologically based pharmacokinetic (PBPK) models have often been used to describe the absorption, distribution, metabolism, and excretion of chemicals in animals but have been limited to single chemicals and simple mixtures due to the numerous par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf384dd53025f95bbcaebe68935b3d44
https://doi.org/10.1021/es035201s
https://doi.org/10.1021/es035201s
Publikováno v:
Environmental Toxicology and Pharmacology. 16:107-119
Petroleum hydrocarbon mixtures such as gasoline, diesel fuel, aviation fuel, and asphalt liquids typically contain hundreds of compounds. These compounds include aliphatic and aromatic hydrocarbons within a specific molecular weight range and sometim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0841369dfcff4f45d334fd5d77a3476e
https://doi.org/10.1016/j.etap.2003.10.003
https://doi.org/10.1016/j.etap.2003.10.003
Publikováno v:
Inhalation Toxicology. 15:961-986
Gasoline consists of a few toxicologically significant components and a large number of other hydrocarbons in a complex mixture. By using an integrated, physiologically based pharmacokinetic (PBPK) modeling and lumping approach, we have developed a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51545ec55c07d8bf6b1228190e19014f
https://doi.org/10.1080/08958370390215749
https://doi.org/10.1080/08958370390215749
Publikováno v:
Environmental Health Perspectives
Signaling motifs (nuclear transcriptional receptors, kinase/phosphatase cascades, G-coupled protein receptors, etc.) have composite dose-response behaviors in relation to concentrations of protein receptors and endogenous signaling molecules. "Molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba7ae00abb304d82868ec99c332e425
https://doi.org/10.1289/ehp.02110s6971
https://doi.org/10.1289/ehp.02110s6971
Autor:
Melvin E. Andersen, James E. Dennison
Publikováno v:
Human and Ecological Risk Assessment: An International Journal. 8:1375-1395
Toxicokinetic (TK) models have many uses, some of which are now regarded as almost routine, in areas related to pharmaceutics, toxicology, and chemical risk assessment. These TK models span a range from simple empirical curve-fitting analyses of bloo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b276c143c0eb46cbc8b7eb74dc584f5
https://doi.org/10.1080/20028091057411
https://doi.org/10.1080/20028091057411
Autor:
Melvin E. Andersen, Julie A. Campain, Michael T. Klein, Brad Reisfeld, Kai H. Liao, Wei Wei, Kenneth F. Reardon, James E. Dennison, Richard J. Quann, Raymond S. H. Yang, Ivan D. Dobrev
Publikováno v:
Environmental Health Perspectives
ResearcherID
Scopus-Elsevier
ResearcherID
Scopus-Elsevier
The complexity and the astronomic number of possible chemical mixtures preclude any systematic experimental assessment of toxicology of all potentially troublesome chemical mixtures. Thus, the use of computer modeling and mechanistic toxicology for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295ad4dc08358a2b971ce32fae882012
http://europepmc.org/articles/PMC1241278
http://europepmc.org/articles/PMC1241278
Autor:
James E. Dennison, Melvin E. Andersen
Publikováno v:
Science of The Total Environment. 274:3-14
Two fundamental concepts have emerged to organize contemporary approaches to chemical risk assessment - mode of action and tissue dosimetry. Mode of action specifies the nature of the interactions between the chemical and the body that lead to toxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1111c53687c2aeaef3774c05baa963
https://doi.org/10.1016/s0048-9697(01)00744-6
https://doi.org/10.1016/s0048-9697(01)00744-6
Autor:
James V. Bruckner, James E. Dennison, Yasong Lu, Hugh A. Barton, Raymond S. H. Yang, Hisham A. El-Masri, Manupat Lohitnavy, Susan H. Rieth
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 50(2)
PBPK modeling has been increasingly applied in chemical risk assessment for dose, route, and species extrapolation. The use of PBPK modeling was explored in deriving toxicity reference values for 1,1,1-trichloroethane (1,1,1-TCE). This effort involve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462d94e4308387d31ed363c3ef9e7512
https://pubmed.ncbi.nlm.nih.gov/18226845
https://pubmed.ncbi.nlm.nih.gov/18226845
Autor:
Raymond S. H. Yang, James E. Dennison
Publikováno v:
Toxicology and applied pharmacology. 223(2)
The inter-relationship of "Thresholds" between chemical mixtures and their respective component single chemicals was studied using three sets of data and two types of analyses. Two in vitro data sets involve cytotoxicity in human keratinocytes from t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69124bfe91dce19014c562c1cccf936c
https://pubmed.ncbi.nlm.nih.gov/18313711
https://pubmed.ncbi.nlm.nih.gov/18313711