Zobrazeno 1 - 10
of 268
pro vyhledávání: '"James E. Darnell"'
Autor:
Rachael L. Philips, Yuxin Wang, HyeonJoo Cheon, Yuka Kanno, Massimo Gadina, Vittorio Sartorelli, Curt M. Horvath, James E. Darnell, George R. Stark, John J. O’Shea
Publikováno v:
Cell
The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway arose from investigations of how cells respond to interferons (IFNs), revealing a paradigm in cell signaling conserved from slime molds to mammals
Publikováno v:
RNA. 24:262-267
By using a cell fraction technique that separates chromatin-associated nascent RNA, newly completed nucleoplasmic mRNA and cytoplasmic mRNA, we have shown in a previous study that residues in exons are methylated (m6A) in nascent pre-mRNA and remain
Publikováno v:
Proceedings of the National Academy of Sciences. 112:14811-14816
Crystallography of the cores of phosphotyrosine-activated dimers of STAT1 (132–713) and STAT3 (127–722) bound to a similar double-stranded deoxyoligonucleotide established the domain structure of the STATs and the structural basis for activation
Publikováno v:
RNA (New York, N.Y.). 24(3)
By using a cell fraction technique that separates chromatin-associated nascent RNA, newly completed nucleoplasmic mRNA and cytoplasmic mRNA, we have shown in a previous study that residues in exons are methylated (m
Autor:
Yuhki Saito, Shay Geula, Shengdong Ke, James E. Darnell, Amy Pandya-Jones, Cathrine Broberg Vågbø, John J. Fak, Robert B. Darnell, Douglas L. Black, Jacob H. Hanna
Publikováno v:
Genes & development, vol 31, iss 10
Understanding the biologic role of N6-methyladenosine (m6A) RNA modifications in mRNA requires an understanding of when and where in the life of a pre-mRNA transcript the modifications are made. We found that HeLa cell chromatin-associated nascent pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::808fb4d0387f1b1d4719955cdb94797b
https://europepmc.org/articles/PMC5495127/
https://europepmc.org/articles/PMC5495127/
Autor:
James E. Darnell
Publikováno v:
Journal of Biological Chemistry. 288:12957-12966
In this Reflections, I review a few early and very lucky events that gave me a running start for the rest of a long and wonderfully enjoyable career. For the main part, a discussion is provided of what I recall as the main illuminating results that m
Autor:
James E. Darnell
Publikováno v:
RNA. 19:443-460
Several strong conclusions emerge concerning pre-mRNA processing from both old and newer experiments. The RNAPII complex is involved with pre-mRNA processing through binding of processing proteins to the CTD (carboxyl terminal domain) of the largest
Autor:
James E. Darnell
Publikováno v:
JAK-STAT
On September 22–24, 2011 a group of over 150 scientists convened at the National Institutes of Health in Bethesda, Maryland to celebrate the 20th anniversary of the definitive molecular studies that revealed the JAK-STAT pathway. Organized chiefly
Autor:
Simi T. Ahmed, James E. Darnell
Publikováno v:
Biochemical and Biophysical Research Communications. 378:821-825
Persistently activated STAT3 contributes to cell survival in many different human cancers. Cancer cell secretion of IL-6 is a frequent basis for persistent STAT3 activation; we show that antibodies against IL-6 or gp-130, the signaling unit of the IL
Publikováno v:
Proceedings of the National Academy of Sciences. 105:13805-13810
The proapoptotic factors Reaper, Hid, Grim, and Sickle regulate apoptosis inDrosophilaby inhibiting the antiapoptotic factor DIAP1 (Drosophilainhibitor of apoptosis 1). Heat, UV light, x-rays, and developmental signals can all increase the proapoptot