Zobrazeno 1 - 10
of 54
pro vyhledávání: '"James E. Blevins"'
Autor:
Melise M. Edwards, Ha K. Nguyen, Andrew D. Dodson, Adam J. Herbertson, Tami Wolden-Hanson, Tomasz A. Wietecha, Mackenzie K. Honeycutt, Jared D. Slattery, Kevin D. O’Brien, James L. Graham, Peter J. Havel, Thomas O. Mundinger, Carl L. Sikkema, Elaine R. Peskind, Vitaly Ryu, Gerald J. Taborsky, James E. Blevins
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Previous studies indicate that CNS administration of oxytocin (OT) reduces body weight in high fat diet-induced obese (DIO) rodents by reducing food intake and increasing energy expenditure (EE). We recently demonstrated that hindbrain (fourth ventri
Externí odkaz:
https://doaj.org/article/337392aeab204df1ad322bed14780b22
Autor:
James E. Blevins, Mackenzie K. Honeycutt, Jared D. Slattery, Matvey Goldberg, June R. Rambousek, Edison Tsui, Andrew D. Dodson, Kyra A. Shelton, Therese S. Salemeh, Clinton T. Elfers, Kylie S. Chichura, Emily F. Ashlaw, Sakeneh Zraika, Robert P. Doyle, Christian L. Roth
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
We recently reported that a novel chimeric peptide (GEP44) targeting both the glucagon-like peptide-1 receptor (GLP-1R) and neuropeptide Y1- and Y2 receptor (Y1R and Y2R) reduced energy intake and body weight (BW) in diet-induced obese (DIO) rats. We
Externí odkaz:
https://doaj.org/article/529ad7d0cfa24b59b26ce81122b9ef1b
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Obesity is a growing health concern, as it increases risk for heart disease, hypertension, type 2 diabetes, cancer, COVID-19 related hospitalizations and mortality. However, current weight loss therapies are often associated with psychiatric or cardi
Externí odkaz:
https://doaj.org/article/3da81f8124b0432a8bb0899d3c26f48a
Autor:
Melise M. Edwards, Ha K. Nguyen, Andrew D. Dodson, Adam J. Herbertson, Tomasz A. Wietecha, Tami Wolden-Hanson, James L. Graham, Mackenzie K. Honeycutt, Jared D. Slattery, Kevin D. O’Brien, Peter J. Havel, James E. Blevins
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Previous studies have indicated that oxytocin (OT) reduces body weight in diet-induced obese (DIO) rodents through reductions in energy intake and increases in energy expenditure. We recently demonstrated that hindbrain [fourth ventricular (4V)] admi
Externí odkaz:
https://doaj.org/article/585fed8fa44843d89e5795268e23b3d5
Autor:
Clinton T. Elfers, James E. Blevins, Elizabeth A. Lawson, Richard Pittner, David Silva, Alex Kiselyov, Christian L. Roth
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Background: Oxytocin is a hypothalamic neuropeptide that participates in the network of appetite regulation. Recently the oxytocin signaling pathway has emerged as an attractive target for treating obesity. However, the short half-life limits its dev
Externí odkaz:
https://doaj.org/article/29db56b194924c0caf182c7f65e2ac73
Autor:
Clinton T. Elfers, James E. Blevins, Therese S. Salameh, Elizabeth A. Lawson, David Silva, Alex Kiselyov, Christian L. Roth
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11249 (2022)
Oxytocin (OXT) analogues have been designed to overcome the limitation of the short half-life of the native OXT peptide. Here, we tested ASK2131 on obesity related outcomes in diet-induced obese (DIO) Sprague Dawley rats. In vitro function assays wer
Externí odkaz:
https://doaj.org/article/78982897aa044ac584775299fd55f532
Autor:
Vishwanath T. Anekonda, Benjamin W. Thompson, Jacqueline M. Ho, Zachary S. Roberts, Melise M. Edwards, Ha K. Nguyen, Andrew D. Dodson, Tami Wolden-Hanson, Daniel W. Chukri, Adam J. Herbertson, James L. Graham, Peter J. Havel, Tomasz A. Wietecha, Kevin D. O’Brien, James E. Blevins
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 21, p 5078 (2021)
Existing studies show that CNS oxytocin (OT) signaling is important in the control of energy balance, but it is unclear which neurons may contribute to these effects. Our goals were to examine (1) the dose-response effects of acute OT administration
Externí odkaz:
https://doaj.org/article/c4b875872ecd4b8ca5893429a933acdb
Autor:
James E. Blevins, James L. Graham, Ha Khanh Nguyen, Tami Wolden-Hanson, Mélise Marie Edwards, Adam Jay Herbertson, Peter J. Havel, Tomasz Wietecha, Andrew Dale Dodson, Kevin D. O'Brien
Publikováno v:
Am J Physiol Regul Integr Comp Physiol
American journal of physiology. Regulatory, integrative and comparative physiology, vol 320, iss 4
American journal of physiology. Regulatory, integrative and comparative physiology, vol 320, iss 4
Previous studies indicate that oxytocin (OT) administration reduces body weight in high-fat diet (HFD)-induced obese (DIO) rodents through both reductions in food intake and increases in energy expenditure. We recently demonstrated that chronic hindb
Publikováno v:
Journal of neuroendocrinology. 34(9)
The neuropeptide oxytocin (OT) has emerged as an important anorexigen in the regulation of food intake and energy balance. It has been shown that the release of OT and activation of hypothalamic OT neurons coincide with food ingestion. Its effects on
Autor:
Richard Pittner, Elizabeth A. Lawson, Alex Kiselyov, Clinton Elfers, Christian L. Roth, David Silva, James E. Blevins
Publikováno v:
Frontiers in Physiology
Frontiers in Physiology, Vol 12 (2021)
Frontiers in Physiology, Vol 12 (2021)
Background: Oxytocin is a hypothalamic neuropeptide that participates in the network of appetite regulation. Recently the oxytocin signaling pathway has emerged as an attractive target for treating obesity. However, the short half-life limits its dev