Zobrazeno 1 - 10
of 15
pro vyhledávání: '"James E. Biggs"'
Autor:
Patrick L. Stemkowski, Edward E. Knaus, Peter A. Smith, Morshed A. Chowdhury, James E. Biggs, Klaus Ballanyi
Publikováno v:
Neuroscience Letters. 584:397-402
The effectiveness of gabapentin (GBP) in the treatment of neuropathic pain depends on access to the α2δ-1 accessory subunit of voltage-gated Ca2+ channels. Access may be limited by its rate of entry via the neuronal system L-neutral amino acid tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::febfc7d341cc0d1731486762c7e7d82c
https://doi.org/10.1016/j.neulet.2014.07.033
https://doi.org/10.1016/j.neulet.2014.07.033
Autor:
Naren Ganesan, Aquilino Lantero, James E. Biggs, Paul A. Boakye, Peter A. Smith, Klaus Ballanyi, Patrick L. Stemkowski
Publikováno v:
Journal of Neurophysiology. 112:2398-2412
The α2δ-ligands pregabalin (PGB) and gabapentin (GBP) are used to treat neuropathic pain. We used whole cell recording to study their long-term effects on substantia gelatinosa and dorsal root ganglion (DRG) neurons. Spinal cord slices were prepare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a959a6dcbf2ff68e58562a8b994c1911
https://doi.org/10.1152/jn.00168.2014
https://doi.org/10.1152/jn.00168.2014
Autor:
N. S. Kumar, Peter A. Smith, Patrick L. Stemkowski, N. Bukhanova, Yishen Chen, James E. Biggs
Publikováno v:
Neurophysiology. 45:67-78
Maladaptive neuropathic pain results from injury or disease of the nervous system. It is typically chronic and frequently intractable. Standard analgesics, such as opioids, are of little use, while gabapentinoids (pregabalin and gabapentin) are not u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9ab6c5eff47c829aa7906941652ee39
https://doi.org/10.1007/s11062-013-9338-9
https://doi.org/10.1007/s11062-013-9338-9
Autor:
Marilyn M. Olmstead, Dean J. Tantillo, Rebecca L. Davis, Brandon Q. Mercado, Jingqiang Wei, Jared T. Shaw, James E. Biggs-Houck
Publikováno v:
The Journal of Organic Chemistry. 77:160-172
Strategies for the formation of carbon-carbon bonds from the α-thioaryl carbonyl products of substituted lactams are described. Although direct functionalization is possible, a two step process of oxidation and magnesium-sulfoxide exchange has prove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b8dd21831f5dc15d2c2ef9b5c877db
https://doi.org/10.1021/jo201541e
https://doi.org/10.1021/jo201541e
Autor:
Julian Yates, James E. Biggs, Nick M. Clayton, Peter P. Robinson, Fiona M. Boissonade, Alison R. Loescher
Publikováno v:
Neuroscience Letters. 443:41-45
Abnormal neural activity generated at a site of nerve injury is thought to contribute to the development of dysaesthesia. Vanilloid receptor 1 (TRPV1), a transducer of noxious stimuli, may be involved in the initiation of this abnormal activity and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb2a17f7fc2f2c3dada5afc217b9d45
https://doi.org/10.1016/j.neulet.2008.06.088
https://doi.org/10.1016/j.neulet.2008.06.088
Autor:
Peter P. Robinson, Alison R. Loescher, Julian Yates, Nick M. Clayton, Fiona M. Boissonade, James E. Biggs
Publikováno v:
Neuroscience Letters. 441:110-114
We have investigated a possible role for the ATP receptor subunit P2X(3), in the development of neuropathic pain following injury to a peripheral branch of the trigeminal nerve. In nine anaesthetised adult ferrets the left lingual nerve was sectioned
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9296017cc2ad8f63142dec4c842dc30f
https://doi.org/10.1016/j.neulet.2008.05.118
https://doi.org/10.1016/j.neulet.2008.05.118
Autor:
Sridhar Balasubramanyan, David Dawbarn, Klaus Ballanyi, Aaron Y. Lai, S. L. Gustafson, James E. Biggs, Peter A. Smith, William F. Colmers, Van B. Lu, Martin J. Stebbing, Kathryn G. Todd
Publikováno v:
Neurophysiology. 39:272-283
Chronic constriction injury (CCI) of the rat sciatic nerve increases the dorsal horn excitability. This “central sensitization” leads to behavioral manifestations analogous to those related to human neuropathic pain. We found, using whole-cell re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe81a7cc276824afbece28b2078cce6f
https://doi.org/10.1007/s11062-007-0038-1
https://doi.org/10.1007/s11062-007-0038-1
Autor:
Dean J. Tantillo, James E. Biggs-Houck, Marilyn M. Olmstead, Rebecca L. Davis, Jingqiang Wei, Brandon Q. Mercado, Jared T. Shaw
Publikováno v:
ChemInform. 43
Strategies for the formation of carbon–carbon bonds from the α-thioaryl carbonyl products of substituted lactams are described. Although direct functionalization is possible, a two step process of oxidation and magnesium-sulfoxide exchange has pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cec06ed1af5ce739ea57ef4bb9206221
https://doi.org/10.1002/chin.201220102
https://doi.org/10.1002/chin.201220102
Autor:
William F. Colmers, James E. Biggs, Van B. Lu, Helena J. Kim, Peter A. Smith, Kathryn G. Todd, Klaus Ballanyi, Aaron Y. Lai
Publikováno v:
Isolated Central Nervous System Circuits ISBN: 9781627030199
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0914f0f10aa21a266e87bb4054a2ba7a
https://doi.org/10.1007/978-1-62703-020-5_14
https://doi.org/10.1007/978-1-62703-020-5_14
Autor:
Michael D. Burkart, Shaun D. Fontaine, Kwang-Seuk Ko, Matthew D Alexander, James E. Biggs-Houck, James J. La Clair
Publikováno v:
Organicbiomolecular chemistry. 8(22)
Two approaches are presented for the synthesis of the macrolide core of the mycolactone polyketides. The first intertwines ring closing metathesis (RCM) within a two-step Julia olefination protocol, while the second intercepts the optimized routes of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::314ae4a81100fcb2a9402fdb7471f323
https://pubmed.ncbi.nlm.nih.gov/20844795
https://pubmed.ncbi.nlm.nih.gov/20844795