Zobrazeno 1 - 10
of 99
pro vyhledávání: '"James E. Audia"'
Autor:
Maria Isabel Loza, Julija Hmeljak, Chas Bountra, James E. Audia, Sohini Chowdhury, Shannon Weiman, Kalpana Merchant, Maria-Jesus Blanco
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 12 (2022)
Externí odkaz:
https://doaj.org/article/863b6f845209443d9567b4c50d10b1c7
Autor:
Alexander M. Taylor, Chris Bailey, Lisa D. Belmont, Robert Campbell, Nico Cantone, Alexandre Côté, Terry D. Crawford, Richard Cummings, Kevin DeMent, Martin Duplessis, Megan Flynn, Andrew C. Good, Hon-Ren Huang, Shivangi Joshi, Yves Leblanc, Jeremy Murray, Christopher G. Nasveschuk, Adrianne Neiss, Florence Poy, F. Anthony Romero, Peter Sandy, Yong Tang, Vickie Tsui, Laura Zawadzke, Robert J. Sims, James E. Audia, Steven F. Bellon, Steven R. Magnuson, Brian K. Albrecht, Andrea G. Cochran
Publikováno v:
Journal of medicinal chemistry. 65(16)
Bromodomains are acetyllysine recognition domains present in a variety of human proteins. Bromodomains also bind small molecules that compete with acetyllysine, and therefore bromodomains have been targets for drug discovery efforts. Highly potent an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e88d18fd974b18b10231a436e2238a9
https://pubmed.ncbi.nlm.nih.gov/35930799
https://pubmed.ncbi.nlm.nih.gov/35930799
Autor:
Maria-Jesus Blanco, James E Audia
Publikováno v:
ACS Med Chem Lett
[Image: see text] Mentoring is an essential opportunity to be embraced by medicinal chemists seeking a gratifying career. In this Viewpoint, we highlight the importance of developing an intentional mindset about mentoring to achieve professional goal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5262e978ab3aa0877c58378ccde50052
https://doi.org/10.1021/acsmedchemlett.9b00638
https://doi.org/10.1021/acsmedchemlett.9b00638
Publikováno v:
Journal of Virology
These results provide the basis for the development of drugs that target enveloped virus budding that can be used ultimately to control multiple virus infections in humans.
In many enveloped virus families, including human immunodeficiency virus
In many enveloped virus families, including human immunodeficiency virus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0198f43cd37e21e27fd0ac429c64331
http://europepmc.org/articles/PMC8139698
http://europepmc.org/articles/PMC8139698
In many enveloped virus families, including HIV and HSV, a crucial, yet unexploited, step in the viral life cycle is releasing particles from the infected cell membranes. This release process is mediated by host ESCRT complex proteins, which is recru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b746f47c20d8419e0bae2f74053acef5
https://doi.org/10.1101/2020.05.04.075036
https://doi.org/10.1101/2020.05.04.075036
Autor:
Venita G. Watson, Richard T. Cummings, Victor S. Gehling, Andrew C. Good, Brian K. Albrecht, Priyanka Sawant, John P. McGrath, James E. Audia, Jean-Christophe Harmange, Priyadarshini Iyer, Rishi G. Vaswani, Srividya Balasubramanian, Alexandre Côté, Avinash Khanna, Steven Bellon, Francois Brucelle, Julian Levell, Patrick Trojer, Jacob I. Stuckey, Martin Duplessis
Publikováno v:
ACS Med Chem Lett
[Image: see text] Leveraging the catalytic machinery of LSD1 (KDM1A), a series of covalent styrenylcyclopropane LSD1 inhibitors were identified. These inhibitors represent a new class of mechanism-based inhibitors that target and covalently label the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb8bd700da48c22429c52efbf950d81b
https://pubmed.ncbi.nlm.nih.gov/32551003
https://pubmed.ncbi.nlm.nih.gov/32551003
Autor:
Arianne Neiss, Martin Duplessis, Hariharan Jayaram, Shumei Wang, F. Anthony Romero, Christopher G. Nasveschuk, Daniel J. Burdick, James E. Audia, Terry Crawford, Steve Bellon, Hon-Ren Huang, Zhaowu Xu, Yongyun Wang, Ying Jiang, Michael C. Hewitt, Jeremy Murray, Andrea G. Cochran, Peter Sandy, Yong Tang, Brian K. Albrecht, E. Megan Flynn, James R. Kiefer, Archana Bommi-Reddy, Jian Wang, Laura Zawadzke, Shivangi Joshi, Vickie Tsui, Xiaoqin Zhu, Alexander M. Taylor, Robert J. Sims, Eneida Pardo, Alexandre Côté, Steven Magnuson, Richard T. Cummings
Publikováno v:
ACS Medicinal Chemistry Letters. 8:737-741
The biological function of bromodomains, epigenetic readers of acetylated lysine residues, remains largely unknown. Herein we report our efforts to discover a potent and selective inhibitor of the bromodomain of cat eye syndrome chromosome region can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34adc0dbe643caf51d004a4e038645f9
https://doi.org/10.1021/acsmedchemlett.7b00132
https://doi.org/10.1021/acsmedchemlett.7b00132
Autor:
Valérie Vivat, Patrick Trojer, Jehrod Burnett Brenneman, James E. Audia, Jennifer A. Mertz, Victor S. Gehling, Shilpi Arora, Ashwin Ramakrishnan, Richard T. Cummings, Ludivine Moine, Jacob I. Stuckey, Robert J. Sims, Nico Cantone, Alexandre Côté, Avinash Khanna, Julian Levell
Publikováno v:
The Journal of Biological Chemistry
The histone methyltransferase EZH2 has been the target of numerous small-molecule inhibitor discovery efforts over the last 10+ years. Emerging clinical data have provided early evidence for single agent activity with acceptable safety profiles for f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17d7df285623b842ff86e83d86e40d53
https://doi.org/10.1016/j.jbc.2021.100349
https://doi.org/10.1016/j.jbc.2021.100349
Autor:
Srividya Balasubramanian, Robert K. Campbell, Patrick Trojer, Christina O. Lee, Jon R. Wilson, Emmanuel Normant, Les A. Dakin, Martin Duplessis, Brian K. Albrecht, Jean-Christophe Harmange, Rishi G. Vaswani, James E. Audia, Priyadarshini Iyer, Andrew Simon Cook, Neil Justin, Steven J. Gamblin, Nico Cantone, Andrew C. Good, Feng Zhao, Richard T. Cummings, Steven F. Bellon, Christopher G. Nasveschuk, Shuyang Chen, Ying Zhang, Victor S. Gehling
Publikováno v:
Journal of Medicinal Chemistry. 59:9928-9941
Polycomb repressive complex 2 (PRC2) has been shown to play a major role in transcriptional silencing in part by installing methylation marks on lysine 27 of histone 3. Dysregulation of PRC2 function correlates with certain malignancies and poor prog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b439dd2f817b39a50f28ca2f51086f0
https://doi.org/10.1021/acs.jmedchem.6b01315
https://doi.org/10.1021/acs.jmedchem.6b01315
Autor:
Robert M. Campbell, Yves Leblanc, James E. Audia, Jennifer A. Mertz, Brian K. Albrecht, Michael R. Cooper, Jeffrey G. Supko, Emmanuel Normant, Florence Poy, Christopher G. Nasveschuk, Richard T. Cummings, Michael C. Hewitt, Adrianne Neiss, Victor S. Gehling, Louise Bergeron, Jean-Christophe Harmange, Peter Sandy, Michael O'Meara, Alexander M. Taylor, Robert J. Sims, Nico Cantone, Eneida Pardo, Alexandre Côté, Shivangi Joshi, Hariharan Jayaram, Rishi G. Vaswani, Steve Bellon
Publikováno v:
Journal of Medicinal Chemistry. 59:1330-1339
In recent years, inhibition of the interaction between the bromodomain and extra-terminal domain (BET) family of chromatin adaptors and acetyl-lysine residues on chromatin has emerged as a promising approach to regulate the expression of important di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a9c61f62ece4a112dbbc1ba0de53887
https://doi.org/10.1021/acs.jmedchem.5b01882
https://doi.org/10.1021/acs.jmedchem.5b01882