Zobrazeno 1 - 10
of 121
pro vyhledávání: '"James E Norton"'
Autor:
James E Norton, Andrew G Lytle, Shixue Shen, Evgeni P Tzvetkov, Corin L Dorfmeier, James P McGettigan
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87098 (2014)
We have previously shown that live-attenuated rabies virus (RABV)-based vaccines infect and directly activate murine and human primary B cells in-vitro, which we propose can be exploited to help develop a single-dose RABV-based vaccine. Here we repor
Externí odkaz:
https://doaj.org/article/13155302d6564e51a863699777ae970f
Autor:
Michael Shaffer, Katharine Best, Catherine Tang, Xue Liang, Steven Schulz, Eduardo Gonzalez, Cory H. White, Thomas P. Wyche, John Kang, Hendrik Wesseling, Begüm D. Topçuoğlu, Thomas Cairns, Theodore R. Sana, Robin M. Kaufhold, Julia M. Maritz, Christopher H. Woelk, Gokul Swaminathan, James E. Norton, Michael E. Pichichero
Publikováno v:
mSystems, Vol 8, Iss 5 (2023)
ABSTRACT Despite multiple vaccine doses early in life, a substantial proportion of infants do not mount protective responses. In this study, we followed a cohort of children over the first 2 years of life, collecting microbiome and metabolome data lo
Externí odkaz:
https://doaj.org/article/e7ffdf61323e4b3cbd3a8d0ab3ea26a1
Autor:
Upasana Parthasarathy, Yi Kuang, Gunjan Thakur, John D. Hogan, Thomas P. Wyche, James E. Norton, Jr., Jason R. Killough, Theodore R. Sana, Caroline Beakes, BaoJen Shyong, Rena N. Zhang, Dario A. Gutierrez, Michael Filbin, David C. Christiani, Alex G. Therien, Christopher H. Woelk, Cory H. White, Roberta Martinelli
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105948- (2023)
Summary: Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Despite continued efforts to understand the pathophysiology of sepsis, no effective therapies are currently available. While singular components of t
Externí odkaz:
https://doaj.org/article/a7bebae0729f4859866504aea19e208c
Autor:
Marcus M. Soliai, Atsushi Kato, Britney A. Helling, Catherine T. Stanhope, James E. Norton, Katherine A. Naughton, Aiko I. Klinger, Emma E. Thompson, Selene M. Clay, Soyeon Kim, Juan C. Celedón, James E. Gern, Daniel J. Jackson, Matthew C. Altman, Robert C. Kern, Bruce K. Tan, Robert P. Schleimer, Dan L. Nicolae, Jayant M. Pinto, Carole Ober
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-22 (2021)
Abstract Background Genome-wide association studies (GWASs) have identified thousands of variants associated with asthma and other complex diseases. However, the functional effects of most of these variants are unknown. Moreover, GWASs do not provide
Externí odkaz:
https://doaj.org/article/4801d6bd42fb43bfb87a30cdbaaf0ea9
Autor:
Abigail L. Reens, Damien J. Cabral, Xue Liang, James E. Norton, Alex G. Therien, Daria J. Hazuda, Gokul Swaminathan
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Emerging evidence in clinical and preclinical studies indicates that success of immunotherapies can be impacted by the state of the microbiome. Understanding the role of the microbiome during immune-targeted interventions could help us understand het
Externí odkaz:
https://doaj.org/article/f6b60dccb4494d5f9ae6e9a732fc83c4
Autor:
Bao-Feng Wang, Ping-Ping Cao, James E. Norton, Julie A. Poposki, Aiko I. Klingler, Lydia A. Suh, Roderick Carter, Julia H. Huang, Junqin Bai, Whitney W. Stevens, Bruce K. Tan, Anju T. Peters, Leslie C. Grammer, David B. Conley, Kevin C. Welch, Zheng Liu, Robert C. Kern, Atsushi Kato, Robert P. Schleimer
Publikováno v:
Journal of Allergy and Clinical Immunology. 151:1379-1390.e11
Autor:
Xue Liang, Begüm D. Topçuoğlu, Erin Spofford, Julia M. Maritz, Sushma Kommineni, Cory H. White, Olga Danilchanka, Daria J. Hazuda, Geoffrey D. Hannigan, Teresa M. Weber, Michael P. Citron, Jianying Xiao, Christopher H. Woelk, Daniel C. Freed, Erin Bryant-Hall, Keun-Joong Lee, Jane Fontenot, Gokul Swaminathan, Gino Salituro, Dario A. Gutierrez, Mahika Kadam, James E. Norton, Abigail L. Reens
Publikováno v:
Vaccines
Volume 9
Issue 11
Vaccines, Vol 9, Iss 1340, p 1340 (2021)
Volume 9
Issue 11
Vaccines, Vol 9, Iss 1340, p 1340 (2021)
Emerging evidence demonstrates a connection between microbiome composition and suboptimal response to vaccines (vaccine hyporesponse). Harnessing the interaction between microbes and the immune system could provide novel therapeutic strategies for im
Autor:
Masafumi Sakashita, Tetsuji Takabayashi, Yoshimasa Imoto, Tetsuya Homma, Kanako Yoshida, Kazuhiro Ogi, Yukihiro Kimura, Atsushi Kato, Whitney W. Stevens, Stephanie S. Smith, Kevin C. Welch, James E. Norton, Lydia A. Suh, Roderick G. Carter, Kathryn E. Hulse, Sudarshan Seshadri, Jin-Young Min, Kathryn L. Pothoven, David B. Conley, Bruce K. Tan, Kathleen E. Harris, Robert C. Kern, Shinichi Haruna, Yoshinori Matsuwaki, Ryosuke Ochiai, Shigeharu Fujieda, Robert P. Schleimer
Publikováno v:
The Journal of allergy and clinical immunology. 150(5)
Patients with aspirin-exacerbated respiratory disease (AERD) regularly exhibit severe nasal polyposis. Studies suggest that chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by excessive fibrin deposition associated with a profound d
Autor:
Soyeon Kim, Aiko I. Klinger, Marcus M. Soliai, Emma E. Thompson, Robert C. Kern, Carole Ober, Atsushi Kato, Selene M. Clay, Catherine Stanhope, Matthew C. Altman, James E. Gern, Daniel J. Jackson, Britney A Helling, Dan L. Nicolae, James E. Norton, Juan C. Celedón, Jayant M. Pinto, Katherine A. Naughton, Bruce K. Tan, Robert P. Schleimer
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-22 (2021)
Genome Medicine
Genome Medicine
Background Genome-wide association studies (GWASs) have identified thousands of variants associated with asthma and other complex diseases. However, the functional effects of most of these variants are unknown. Moreover, GWASs do not provide context-
Autor:
Ping-Ping Cao, Bao-Feng Wang, James E. Norton, Lydia A. Suh, Roderick G. Carter, Whitney W. Stevens, Anna G. Staudacher, Julia H. Huang, Kathryn E. Hulse, Anju T. Peters, Leslie C. Grammer, David B. Conley, Kevin C. Welch, Robert C. Kern, Zheng Liu, Jingying Ye, Robert P. Schleimer
Publikováno v:
The Journal of allergy and clinical immunology. 150(2)
Increased activation of the coagulation cascade and diminished fibrinolysis combine to promote fibrin deposition and polyp formation in chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP). More information is needed concerning mechanisms of coagu