Non-invasive detection of early retinal neuronal degeneration by ultrahigh resolution optical coherence tomography.

Autor: Debbie Tudor, Vedran Kajić, Sara Rey, Irina Erchova, Boris Považay, Bernd Hofer, Kate A Powell, David Marshall, Paul L Rosin, Wolfgang Drexler, James E Morgan

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e93916 (2014)

Optical coherence tomography (OCT) has revolutionises the diagnosis of retinal disease based on the detection of microscopic rather than subcellular changes in retinal anatomy. However, currently the technique is limited to the detection of microscop

Externí odkaz: https://doaj.org/article/c481fd0469244bdaab36793b7ec4c186

Crowdsourcing as a novel technique for retinal fundus photography classification: analysis of images in the EPIC Norfolk cohort on behalf of the UK Biobank Eye and Vision Consortium.

Autor: Danny Mitry, Tunde Peto, Shabina Hayat, James E Morgan, Kay-Tee Khaw, Paul J Foster

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e71154 (2013)

Crowdsourcing is the process of outsourcing numerous tasks to many untrained individuals. Our aim was to assess the performance and repeatability of crowdsourcing for the classification of retinal fundus photography.One hundred retinal fundus photogr

Externí odkaz: https://doaj.org/article/98ab8e11f5e24b52baf406ebdea98529

Retinal ganglion cell degeneration correlates with hippocampal spine loss in experimental Alzheimer’s disease

Autor: Ryan J. Bevan, Tim R. Hughes, Pete A. Williams, Mark A. Good, B. Paul Morgan, James E. Morgan

Publikováno v: Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-13 (2020)

Abstract Neuronal dendritic and synaptic pruning are early features of neurodegenerative diseases, including Alzheimer’s disease. In addition to brain pathology, amyloid plaque deposition, microglial activation, and cell loss occur in the retinas o

Externí odkaz: https://doaj.org/article/61a61e0eabc6470bbf42d6cef97e7105

Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction

Autor: James R. Tribble, Amin Otmani, Shanshan Sun, Sevannah A. Ellis, Gloria Cimaglia, Rupali Vohra, Melissa Jöe, Emma Lardner, Abinaya P. Venkataraman, Alberto Domínguez-Vicent, Eirini Kokkali, Seungsoo Rho, Gauti Jóhannesson, Robert W. Burgess, Peter G. Fuerst, Rune Brautaset, Miriam Kolko, James E. Morgan, Jonathan G. Crowston, Marcela Votruba, Pete A. Williams

Publikováno v: Redox Biology, Vol 43, Iss , Pp 101988- (2021)

Nicotinamide adenine dinucleotide (NAD) is a REDOX cofactor and metabolite essential for neuronal survival. Glaucoma is a common neurodegenerative disease in which neuronal levels of NAD decline. We assess the effects of nicotinamide (a precursor to

Externí odkaz: https://doaj.org/article/11535b7d2b994327966f83eaacbf9faa

The association between serum lipids and intraocular pressure in 2 large United Kingdom cohorts

Autor: Kian M. Madjedi, Kelsey V. Stuart, Sharon Y.L. Chua, Robert N. Luben, Alasdair Warwick, Louis R. Pasquale, Jae H. Kang, Janey L. Wiggs, Marleen A.H. Lentjes, Hugues Aschard, Naveed Sattar, Paul J. Foster, Anthony P. Khawaja, Mark Chia, Ron Do, Alan Kastner, Jihye Kim, Giovanni Montesano, Denize Atan, Tariq Aslam, Sarah A. Barman, Jenny H. Barrett, Paul Bishop, Peter Blows, Catey Bunce, Roxana O. Carare, Usha Chakravarthy, Michelle Chan, David P. Crabb, Philippa M. Cumberland, Alexander Day, Parul Desai, Bal Dhillon, Andrew D. Dick, Cathy Egan, Sarah Ennis, Paul Foster, Marcus Fruttiger, John E.J. Gallacher, David F. Garway-Heath, Jane Gibson, Dan Gore, Jeremy A. Guggenheim, Chris J. Hammond, Alison Hardcastle, Simon P. Harding, Ruth E. Hogg, Pirro Hysi, Pearse A. Keane, Sir Peng T. Khaw, Gerassimos Lascaratos, Andrew J. Lotery, Tom Macgillivray, Sarah Mackie, Keith Martin, Michelle McGaughey, Bernadette McGuinness, Gareth J. McKay, Martin McKibbin, Danny Mitry, Tony Moore, James E. Morgan, Zaynah A. Muthy, Eoin O’Sullivan, Chris G. Owen, Praveen Patel, Euan Paterson, Tunde Peto, Axel Petzold, Jugnoo S. Rahi, Alicja R. Rudnikca, Jay Self, Sobha Sivaprasad, David Steel, Irene Stratton, Nicholas Strouthidis, Cathie Sudlow, Dhanes Thomas, Emanuele Trucco, Adnan Tufail, Veronique Vitart, Stephen A. Vernon, Ananth C. Viswanathan, Cathy Williams, Katie Williams, Jayne V. Woodside, MaxM. Yates, Jennifer Yip, Yalin Zheng

Publikováno v: Modifiable Risk Factors for Glaucoma Collaboration and the UK Biobank Eye and Vision Consortium, Madjedi, K M, Stuart, K V, Chua, S Y L, Luben, R N, Warwick, A, Pasquale, L R, Kang, J H, Wiggs, J L, Lentjes, M A H, Aschard, H, Sattar, N, Foster, P J, Khawaja, A P, Chia, M, Do, R, Kastner, A, Kim, J, Montesano, G, Atan, D, Aslam, T, Barman, S A, Barrett, J H, Bishop, P, Blows, P, Bunce, C, Carare, R O, Chakravarthy, U, Chan, M, Crabb, D P, Cumberland, P M, Day, A, Desai, P, Dhillon, B, Dick, A D, Egan, C, Ennis, S, Foster, P, Fruttiger, M, Gallacher, J E J, Garway-Heath, D F, Gibson, J, Gore, D, Hogg, R E, McGaughey, M, McGuinness, B, McKay, G J, Paterson, E, Peto, T, Steel, D & Woodside, J V 2022, ' The Association between Serum Lipids and Intraocular Pressure in 2 Large United Kingdom Cohorts ', Ophthalmology, vol. 129, no. 9, pp. 986-996 . https://doi.org/10.1016/j.ophtha.2022.04.023
Modifiable Risk Factors for Glaucoma Collaboration and the UK Biobank Eye and Vision Consortium 2022, ' The Association between Serum Lipids and Intraocular Pressure in 2 Large United Kingdom Cohorts ', Ophthalmology, vol. 129, no. 9, pp. 986-996 . https://doi.org/10.1016/j.ophtha.2022.04.023
Ophthalmology: Journal of The American Academy of Ophthalmology
Ophthalmology: Journal of The American Academy of Ophthalmology, 2022, 129 (9), pp.986-996. ⟨10.1016/j.ophtha.2022.04.023⟩
Ophthalmology, 129(9), 986-996. Elsevier Inc.

Purpose: Serum lipids are modifiable, routinely collected blood test features associated with cardiovascular health. We examined the association of commonly collected serum lipid measures (total cholesterol [TC], high-density lipoprotein cholesterol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee73fd6f3ad69cfc1b0fa0ee7b1daba
https://eprints.soton.ac.uk/470583/