Zobrazeno 1 - 10
of 255
pro vyhledávání: '"James E Klaunig"'
Autor:
Priyom Adhyapok, Xiao Fu, James P Sluka, Sherry G Clendenon, Victoria D Sluka, Zemin Wang, Kenneth Dunn, James E Klaunig, James A Glazier
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243451 (2020)
Drug induced liver injury (DILI) and cell death can result from oxidative stress in hepatocytes. An initial pattern of centrilobular damage in the APAP model of DILI is amplified by communication from stressed cells and immune system activation. Whil
Externí odkaz:
https://doaj.org/article/5bbadffbbea14e2d947bac17c18ffe2e
Autor:
Xiao Fu, James P Sluka, Sherry G Clendenon, Kenneth W Dunn, Zemin Wang, James E Klaunig, James A Glazier
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0198060 (2018)
Computational models of normal liver function and xenobiotic induced liver damage are increasingly being used to interpret in vitro and in vivo data and as an approach to the de novo prediction of the liver's response to xenobiotics. The microdosimet
Externí odkaz:
https://doaj.org/article/77faf0bce05e48aab4de960dd826f832
Autor:
Timothy M Coskran, Zhijie Jiang, James E Klaunig, Dixie L Mager, Leslie Obert, Andrew Robertson, Nicholas Tsinoremas, Zemin Wang, Mark Gosink
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176768 (2017)
A number of chemical compounds have been shown to induce liver tumors in mice but not in other species. While several mechanisms for this species-specific tumorigenicity have been proposed, no definitive mechanism has been established. We examined th
Externí odkaz:
https://doaj.org/article/77f70d26f5cc49d79b7be814cb53e00a
Autor:
Barbara A Hocevar, Lisa M Kamendulis, Xinzhu Pu, Susan M Perkins, Zheng-Yu Wang, Erica L Johnston, John M DeWitt, Lang Li, Patrick J Loehrer, James E Klaunig, E Gabriela Chiorean
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90052 (2014)
Several risk factors have been identified as potential contributors to pancreatic cancer development, including environmental and lifestyle factors, such as smoking, drinking and diet, and medical conditions such as diabetes and pancreatitis, all of
Externí odkaz:
https://doaj.org/article/64ead8c36f794c6f9d18d3b79cc723be
Autor:
Gio B. Gori, Michael Aschner, Christopher J. Borgert, Samuel M. Cohen, Daniel R. Dietrich, Corrado L. Galli, Helmut Greim, John S. Heslop-Harrison, Sam Kacew, Norbert E. Kaminski, James E. Klaunig, Hans W.J. Marquardt, Olavi Pelkonen, Ruth Roberts, Kai M. Savolainen, Aristidis Tsatsakis, Hiroshi Yamazaki
Publikováno v:
Archives of Toxicology. 97:1813-1822
The 1958 Delaney amendment to the Federal Food Drug and Cosmetics Act prohibited food additives causing cancer in animals by appropriate tests. Regulators responded by adopting chronic lifetime cancer tests in rodents, soon challenged as inappropriat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f93d8c4c20fda41ae2780a1ad9e33486
https://doi.org/10.1007/s00204-022-03429-5
https://doi.org/10.1007/s00204-022-03429-5
Autor:
Elise Slevin, Sachiko Koyama, Kelly Harrison, Ying Wan, James E. Klaunig, Chaodong Wu, Ashok K. Shetty, Fanyin Meng
Publikováno v:
Journal of Cellular and Molecular Medicine. 27:891-905
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c28b211ebe622e2bb742b57b2c229f48
https://doi.org/10.1111/jcmm.17631
https://doi.org/10.1111/jcmm.17631
Publikováno v:
Toxicological Sciences. 192:15-29
HFPO-DA (ammonium, 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate) is a short-chain polyfluorinated alkyl substance (PFAS) used in the manufacture of some types of fluorinated polymers. Like many PFAS, toxicity studies with HFPO-DA indicate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9607b33433b019341e35e8e516c2273
https://doi.org/10.1093/toxsci/kfad004
https://doi.org/10.1093/toxsci/kfad004
Autor:
Ying Wan, Elise Slevin, Sachiko Koyama, Chiung-Kuei Huang, Ashok K Shetty, Xuedong Li, Kelly Harrison, Tian Li, Bingru Zhou, Sugeily Ramos Lorenzo, Yudian Zhang, Jennifer Mata Salinas, Wenjuan Xu, James E. Klaunig, Chaodong Wu, Hidekazu Tsukamoto, Fanyin Meng
Publikováno v:
Hepatology Communications. 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57a57d9d577e28a8d370169c8838257b
https://doi.org/10.1097/hc9.0000000000000089
https://doi.org/10.1097/hc9.0000000000000089
Autor:
J Christopher Corton, Constance A Mitchell, Scott Auerbach, Pierre Bushel, Heidrun Ellinger-Ziegelbauer, Patricia A Escobar, Roland Froetschl, Alison H Harrill, Kamin Johnson, James E Klaunig, Arun R Pandiri, Alexei A Podtelezhnikov, Julia E Rager, Keith Q Tanis, Jan Willem van der Laan, Alisa Vespa, Carole L Yauk, Syril D Pettit, Frank D Sistare
Publikováno v:
Toxicological Sciences. 188:4-16
There is growing recognition across broad sectors of the scientific community that use of genomic biomarkers has the potential to reduce the need for conventional rodent carcinogenicity studies of industrial chemicals, agrochemicals, and pharmaceutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab1ea167ef959d91cb05ee2aeb0e6fc9
https://doi.org/10.1093/toxsci/kfac041
https://doi.org/10.1093/toxsci/kfac041
Autor:
Ying Wan, Tianhao Zhou, Elise Slevin, Sachiko Koyama, Xuedong Li, Kelly Harrison, Tian Li, Bingru Zhou, Sugeily Ramos Lorenzo, Yudian Zhang, Wenjuan Xu, James E. Klaunig, Chaodong Wu, Ashok K. Shetty, Chiung‐Kuei Huang, Fanyin Meng
Publikováno v:
The FASEB Journal. 37
Primary sclerosing cholangitis (PSC) is a chronic liver disease characterized by inflammatory responses and fibrotic scar formation leading to cholestasis. Ductular reaction and liver fibrosis are typical liver changes seen in human PSC and cholestas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a93d69e5d49f6761816d6489c756a981
https://doi.org/10.1096/fj.202201453r
https://doi.org/10.1096/fj.202201453r