Zobrazeno 1 - 10
of 268
pro vyhledávání: '"James E Goldman"'
Autor:
Rachel A Battaglia, Adriana S Beltran, Samed Delic, Raluca Dumitru, Jasmine A Robinson, Parijat Kabiraj, Laura E Herring, Victoria J Madden, Namritha Ravinder, Erik Willems, Rhonda A Newman, Roy A Quinlan, James E Goldman, Ming-Der Perng, Masaki Inagaki, Natasha T Snider
Publikováno v:
eLife, Vol 8 (2019)
Alexander disease (AxD) is a fatal neurodegenerative disorder caused by mutations in glial fibrillary acidic protein (GFAP), which supports the structural integrity of astrocytes. Over 70 GFAP missense mutations cause AxD, but the mechanism linking d
Externí odkaz:
https://doaj.org/article/1a944b07b95f440191c0e5f0e38980a8
Autor:
Fahad Paryani, Ji-Sun Kwon, Christopher W. Ng, Kelly Jakubiak, Nacoya Madden, Kenneth Ofori, Alice Tang, Hong Lu, Shengnan Xia, Juncheng Li, Aayushi Mahajan, Shawn M. Davidson, Anna O. Basile, Caitlin McHugh, Jean Paul Vonsattel, Richard Hickman, Michael C. Zody, David E. Housman, James E. Goldman, Andrew S. Yoo, Vilas Menon, Osama Al-Dalahmah
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract The mechanisms underlying the selective regional vulnerability to neurodegeneration in Huntington’s disease (HD) have not been fully defined. To explore the role of astrocytes in this phenomenon, we used single-nucleus and bulk RNAseq, lip
Externí odkaz:
https://doaj.org/article/8951e53b83a446a78dbb4875a502960b
Autor:
Jose eGutierrez, Gorazd eRosoklija, Jacinta eMurray, Christina eChon, Mitchell SV Elkind, James E Goldman, Lawrence eHonig, Andrew J Dwork, Susan eMorgello, Randolph S Marshall
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
Mechanisms underlying brain arterial remodeling are uncertain. We tested the hypothesis that arterial size and location are important determinants of arterial characteristics. We collected large and penetrating brain arteries from cadavers with and w
Externí odkaz:
https://doaj.org/article/c0cbbcc21f78400f826994292595133a
Autor:
Eun Sook Jang, James E Goldman
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20894 (2011)
The forebrain subventricular zone (SVZ) of neonatal mammals contains a large, heterogeneous population of migratory and proliferating precursors of interneurons and glia. These cell types are produced in large numbers in the immediate postnatal perio
Externí odkaz:
https://doaj.org/article/e233fa3718604d0195aedda3994c78c4
Autor:
Ryan G. Lim, Osama Al-Dalahmah, Jie Wu, Maxwell P. Gold, Jack C. Reidling, Guomei Tang, Miriam Adam, David K. Dansu, Hye-Jin Park, Patrizia Casaccia, Ricardo Miramontes, Andrea M. Reyes-Ortiz, Alice Lau, Richard A. Hickman, Fatima Khan, Fahad Paryani, Alice Tang, Kenneth Ofori, Emily Miyoshi, Neethu Michael, Nicolette McClure, Xena E. Flowers, Jean Paul Vonsattel, Shawn Davidson, Vilas Menon, Vivek Swarup, Ernest Fraenkel, James E. Goldman, Leslie M. Thompson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)
Here the authors evaluate single cell gene expression from mouse and human Huntington’s disease brains, finding incomplete oligodendrocyte maturation and pathways involved. Treating mice with thiamine/biotin ameliorates molecular pathology.
Externí odkaz:
https://doaj.org/article/3ad164ee693049358f658929a36c0698
Autor:
Nacoya Madden, Ying Zi Jessy Mei, Kelly Jakubiak, Juncheng Li, Gunnar Hargus, James E. Goldman, Osama Al-Dalahmah
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
The pathological involvement of the central nervous system in SARS-CoV2 (COVID-19) patients is established. The burden of pathology is most pronounced in the brain stem including the medulla oblongata. Hypoxic/ischemic damage is the most frequent neu
Externí odkaz:
https://doaj.org/article/059194ecb4d44417b4ffe9f363af65da
Autor:
Osama Al-Dalahmah, Alexander A. Sosunov, Yu Sun, Yang Liu, Nacoya Madden, E. Sander Connolly, Carol M. Troy, Guy M. McKhann, James E. Goldman
Publikováno v:
Cells, Vol 13, Iss 2, p 129 (2024)
In the mammalian isocortex, CD44, a cell surface receptor for extracellular matrix molecules, is present in pial-based and fibrous astrocytes of white matter but not in protoplasmic astrocytes. In the hominid isocortex, CD44+ astrocytes comprise the
Externí odkaz:
https://doaj.org/article/ca845e2049f9456694582ee77233a2d0
Autor:
Bridget Shafit-Zagardo, Simone Sidoli, James E. Goldman, Juwen C. DuBois, John R. Corboy, Stephen M. Strittmatter, Hillary Guzik, Ukuemi Edema, Anita G. Arackal, Yair M. Botbol, Emilio Merheb, Rashed M. Nagra, Sarah Graff
Publikováno v:
Cells, Vol 12, Iss 13, p 1734 (2023)
During inflammatory, demyelinating diseases such as multiple sclerosis (MS), inflammation and axonal damage are prevalent early in the course. Axonal damage includes swelling, defects in transport, and failure to clear damaged intracellular proteins,
Externí odkaz:
https://doaj.org/article/fd1f67f30de94928b8ba0eb64c0dde6f
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 81:988-995
The brain of a 58-year-old woman was included as a civilian control in an ongoing autopsy study of military traumatic brain injury (TBI). The woman died due to a polysubstance drug overdose, with Coronavirus Disease 2019 (COVID-19) serving as a contr
Autor:
Graff, Bridget Shafit-Zagardo, Simone Sidoli, James E. Goldman, Juwen C. DuBois, John R. Corboy, Stephen M. Strittmatter, Hillary Guzik, Ukuemi Edema, Anita G. Arackal, Yair M. Botbol, Emilio Merheb, Rashed M. Nagra, Sarah
Publikováno v:
Cells; Volume 12; Issue 13; Pages: 1734
During inflammatory, demyelinating diseases such as multiple sclerosis (MS), inflammation and axonal damage are prevalent early in the course. Axonal damage includes swelling, defects in transport, and failure to clear damaged intracellular proteins,