Zobrazeno 1 - 10
of 666
pro vyhledávání: '"James E Gern"'
Autor:
Matthew Dapas, Emma E Thompson, William Wentworth-Sheilds, Selene Clay, Cynthia M Visness, Agustin Calatroni, Joanne E Sordillo, Diane R Gold, Robert A Wood, Melanie Makhija, Gurjit K Khurana Hershey, Michael G Sherenian, Rebecca S Gruchalla, Michelle A Gill, Andrew H Liu, Haejin Kim, Meyer Kattan, Leonard B Bacharier, Deepa Rastogi, Matthew C Altman, William W Busse, Patrice M Becker, Dan Nicolae, George T O'Connor, James E Gern, Daniel J Jackson, Carole Ober
Publikováno v:
PLoS Genetics, Vol 19, Iss 1, p e1010594 (2023)
Impaired lung function in early life is associated with the subsequent development of chronic respiratory disease. Most genetic associations with lung function have been identified in adults of European descent and therefore may not represent those m
Externí odkaz:
https://doaj.org/article/d10dc071b47a4cef941d868fd30e4720
Autor:
Jonathan Grigg, Heather J Zar, David Price, Michael Miligkos, Giuseppe De Carlo, Peter N Le Souëf, Tim Felton, Graham Roberts, Jose A Castro-Rodriguez, Stephen Turner, Alexander G Mathioudakis, Gioulinta S Alimani, Georgios A Mathioudakis, Effie Papageorgiou, Nikolaos G Papadopoulos, Apostolos Beloukas, Ioanna Tsiligianni, Despo Ierodiakonou, Tuomas Jartti, A Deschildre, Wojciech Feleszko, Matteo Bonini, Clare Murray, Adnan Custovic, Mário Morais-Almeida, Wanda Phipatanakul, Mika J Mäkelä, Gunilla Hedlin, Robert F Lemanske, Paraskevi Xepapadaki, James E Gern, Cristina Boccabella, Francine Monique Ducharme, Omer Kalayci, Antonio Nieto Garcia, Ioana Octavia Agache, Leonard Bacharier, Timothy Craig, Zuzana Diamant, Elham M Hossny, Alan Kaplan, Paolo Matricardi, Marina Mitrogiorgou, Karthik Nagaraju, Helena Pité, Paulo M C Pitrez, Petr Pohunek, Susanne Vijverberg, Tonya A Winders, Gary WK Wong
Publikováno v:
BMJ Open, Vol 11, Iss 7 (2021)
Introduction Clinical recommendations for childhood asthma are often based on data extrapolated from studies conducted in adults, despite significant differences in mechanisms and response to treatments. The Paediatric Asthma in Real Life (PeARL) Thi
Externí odkaz:
https://doaj.org/article/7da0701f3db645d682a85f343fc77ba9
Autor:
Leah Cuthbertson, Stephen W C Oo, Michael J Cox, Siew-Kim Khoo, Des W Cox, Glenys Chidlow, Kimberley Franks, Franciska Prastanti, Meredith L Borland, James E Gern, David W Smith, Joelene A Bizzintino, Ingrid A Laing, Peter N Le Souëf, Miriam F Moffatt, William O C Cookson
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223990 (2019)
Acute viral wheeze in children is a major cause of hospitalisation and a major risk factor for the development of asthma. However, the role of the respiratory tract microbiome in the development of acute wheeze is unclear. To investigate whether seve
Externí odkaz:
https://doaj.org/article/9744bb3b496547a790bdfc405d1bc6f7
Autor:
Howard HF Tang, Shu Mei Teo, Danielle CM Belgrave, Michael D Evans, Daniel J Jackson, Marta Brozynska, Merci MH Kusel, Sebastian L Johnston, James E Gern, Robert F Lemanske, Angela Simpson, Adnan Custovic, Peter D Sly, Patrick G Holt, Kathryn E Holt, Michael Inouye
Publikováno v:
eLife, Vol 7 (2018)
Events in early life contribute to subsequent risk of asthma; however, the causes and trajectories of childhood wheeze are heterogeneous and do not always result in asthma. Similarly, not all atopic individuals develop wheeze, and vice versa. The rea
Externí odkaz:
https://doaj.org/article/f6970abb9eee4e419db29b2af8d88136
Autor:
Steven M Brunwasser, Tebeb Gebretsadik, Diane R Gold, Kedir N Turi, Cosby A Stone, Soma Datta, James E Gern, Tina V Hartert
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0194739 (2018)
BACKGROUND:The International Study of Asthma and Allergies in Children (ISAAC) Wheezing Module is commonly used to characterize pediatric asthma in epidemiological studies, including nearly all airway cohorts participating in the Environmental Influe
Externí odkaz:
https://doaj.org/article/3c4e8df0eccd45a19df5f1aca01057f8
Autor:
Matthew C Tattersall, Michael D Evans, Claudia E Korcarz, Carol Mitchell, Elizabeth Anderson, Douglas F DaSilva, Lisa P Salazar, James E Gern, Daniel J Jackson, Robert F Lemanske, James H Stein
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0204708 (2018)
BACKGROUND:Asthma is associated with an increased cardiovascular disease (CVD) risk in adults, but the impact of asthma and atopic conditions on CVD risk in children is less well established. We hypothesized that children in the Childhood Origins of
Externí odkaz:
https://doaj.org/article/cf28594acf6e4d09a9fe9ad533b21a2f
Autor:
Tonia S. Afshan, MD, MPH, Aishwarya Kulkarni, MPH, Jennifer M. Smith, BS, Elizabeth Tesson, BSN, Talissa Blackshere, RN, BSN, Christine Joseph, PhD, Edward M. Zoratti, MD, Katherine Rivera-Spoljaric, MD, Tina Hartert, MD, James E. Gern, MD, Anne Marie Singh, MD
Publikováno v:
Journal of Allergy and Clinical Immunology: Global, Vol 3, Iss 3, Pp 100270- (2024)
Background: Recruitment for research studies is a challenging endeavor that was further complicated by the coronavirus disease 2019 pandemic. We launched a new multicenter birth cohort, Childhood Allergy and the NeOnatal Environment (CANOE), supporte
Externí odkaz:
https://doaj.org/article/f9ba9340ac1f4255831552f8050c5731
Autor:
Catarina D Campbell, Kiana Mohajeri, Maika Malig, Fereydoun Hormozdiari, Benjamin Nelson, Gaixin Du, Kristen M Patterson, Celeste Eng, Dara G Torgerson, Donglei Hu, Catherine Herman, Jessica X Chong, Arthur Ko, Brian J O'Roak, Niklas Krumm, Laura Vives, Choli Lee, Lindsey A Roth, William Rodriguez-Cintron, Jose Rodriguez-Santana, Emerita Brigino-Buenaventura, Adam Davis, Kelley Meade, Michael A LeNoir, Shannon Thyne, Daniel J Jackson, James E Gern, Robert F Lemanske, Jay Shendure, Mark Abney, Esteban G Burchard, Carole Ober, Evan E Eichler
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104396 (2014)
Asthma is a complex genetic disease caused by a combination of genetic and environmental risk factors. We sought to test classes of genetic variants largely missed by genome-wide association studies (GWAS), including copy number variants (CNVs) and l
Externí odkaz:
https://doaj.org/article/98e7e72d10cd4b5ca2e3cbed7c9bd96a
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86755 (2014)
Vitamin D has been linked to reduced risk of viral respiratory illness. We hypothesized that vitamin D could directly reduce rhinovirus (RV) replication in airway epithelium. Primary human bronchial epithelial cells (hBEC) were treated with vitamin D
Externí odkaz:
https://doaj.org/article/79cd42fd97404962915b8a981794650c
Autor:
Elizabeth A Hines, Renee J Szakaly, Ning Leng, Anais T Webster, Jamie M Verheyden, Amber J Lashua, Christina Kendziorski, Louis A Rosenthal, James E Gern, Ronald L Sorkness, Xin Sun, Robert F Lemanske
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e112997 (2014)
Early life respiratory viral infections and atopic characteristics are significant risk factors for the development of childhood asthma. It is hypothesized that repeated respiratory viral infections might induce structural remodeling by interfering w
Externí odkaz:
https://doaj.org/article/4644f1a0f42745ebb639e8b79967079d