Zobrazeno 1 - 10
of 125
pro vyhledávání: '"James E Casanova"'
Autor:
Ryan S D'Souza, Jun Y Lim, Alper Turgut, Kelly Servage, Junmei Zhang, Kim Orth, Nisha G Sosale, Matthew J Lazzara, Jeremy Allegood, James E Casanova
Publikováno v:
eLife, Vol 9 (2020)
Coordinated assembly and disassembly of integrin-mediated focal adhesions (FAs) is essential for cell migration. Many studies have shown that FA disassembly requires Ca2+ influx, however our understanding of this process remains incomplete. Here, we
Externí odkaz:
https://doaj.org/article/ccb351f40ae24823b1c3f79d2970f156
Publikováno v:
PLoS Pathogens, Vol 10, Iss 6, p e1004159 (2014)
Autophagy has emerged as an important antimicrobial host defense mechanism that not only orchestrates the systemic immune response, but also functions in a cell autonomous manner to directly eliminate invading pathogens. Pathogenic bacteria such as S
Externí odkaz:
https://doaj.org/article/ae3dd5922ad94caca70ddeb6a6d1164e
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23123 (2011)
Following damage to the intestinal epithelium, restoration of epithelial barrier integrity is triggered by a robust proliferative response. In other tissues, focal adhesion kinase (FAK) regulates many of the cellular processes that are critical for e
Externí odkaz:
https://doaj.org/article/32a3398e065841ca9677d4d18c14e8b2
Publikováno v:
Small GTPases. 13(1)
The small GTPase RhoA controls many important cellular processes through its ability to activate multiple downstream effector pathways. Most RhoA effectors contain a Rho-binding domain (RBD), and interaction between active RhoA and the RBD typically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceec4346df7d566cc9737fa35eb94526
https://pubmed.ncbi.nlm.nih.gov/35950594
https://pubmed.ncbi.nlm.nih.gov/35950594
Autor:
James E. Casanova
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 4, Iss 2, Pp 237-243 (2017)
Autophagy is a fundamental cellular process used for the turnover and recycling of cytosolic components and damaged organelles. Originally characterized as a response to cellular stress, it now is well established that autophagy also is used as a def
Externí odkaz:
https://doaj.org/article/cfdd260939c94a74830dfb33d59ef1f3
Publikováno v:
Gastroenterology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d0b74da508985074d466fa69df34d0a
https://doi.org/10.1053/j.gastro.2023.04.018
https://doi.org/10.1053/j.gastro.2023.04.018
Recognition of lipopolysaccharide (LPS) is critical for host defense against Gram-negative bacteria and the regulation of local inflammatory responses at the host-microbial interface. We have previously shown that the adhesion G-protein-coupled recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc78c8e1e549ab04989cf0c49a2fb366
https://doi.org/10.1101/2023.01.30.525907
https://doi.org/10.1101/2023.01.30.525907
Autor:
Katherine R Hardin, Michael P. East, Tamara Caspary, Joshua Linnert, Tala O. Khatib, Uwe Wolfrum, Michael J Lim, James E. Casanova, Yihan Hu, Narra S. Devi, Rachel E. Turn, Skylar I. Dewees, Richard A. Kahn
Publikováno v:
Mol Biol Cell
ELMODs are a family of three mammalian paralogs that display GTPase activating protein (GAP) activity towards a uniquely broad array of ADP-ribosylation factor (ARF) family GTPases that includes ARF-like (ARL) proteins. ELMODs are ubiquitously expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d7e8f77059d82a2603afff8c1248b0
https://europepmc.org/articles/PMC9561853/
https://europepmc.org/articles/PMC9561853/
Publikováno v:
mBio, Vol 7, Iss 1 (2016)
ABSTRACT Salmonella enterica is an intracellular pathogen that causes diseases ranging from gastroenteritis to typhoid fever. Salmonella bacteria trigger an autophagic response in host cells upon infection but have evolved mechanisms for suppressing
Externí odkaz:
https://doaj.org/article/f6a38c9960ce4835b5fd5756c48294e0
Autor:
Katherine R Hardin, Rachel E. Turn, James E. Casanova, Michael P. East, Tala O. Khatib, Narra S. Devi, Richard A. Kahn, Tamara Caspary, J. Y. Lim, Yi-Juan Hu, Skylar I. Dewees, Joshua Linnert, Uwe Wolfrum
ELMODs are a family of three mammalian paralogs that display GTPase activating protein (GAP) activity towards a uniquely broad array of ADP-ribosylation factor (ARF) family GTPases that includes ARF-like (ARL) proteins. ELMODs are ubiquitously expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d605689d5921ffe8da5823b68585f92
https://doi.org/10.1101/2021.09.15.460558
https://doi.org/10.1101/2021.09.15.460558