Zobrazeno 1 - 10
of 347
pro vyhledávání: '"James E, Trosko"'
Autor:
James E. Trosko
Publikováno v:
Life, Vol 11, Iss 12, p 1308 (2021)
In this Commentary, the operational definition of cancer stem cells or cancer initiating cells includes the ability of certain cells, found in a heterogeneous mixture of cells within a tumor, which are able to sustain growth of that tumor. However, t
Externí odkaz:
https://doaj.org/article/e70b75f8de0e4c7fb3617a479e06c2ba
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8977 (2021)
Dysregulation of gap junction intercellular communication (GJIC) is recognized as one of the key hallmarks for identifying non-genotoxic carcinogens (NGTxC). Currently, there is a demand for in vitro assays addressing the gap junction hallmark, which
Externí odkaz:
https://doaj.org/article/3e4c14d6f47946469a1a39623228f27c
Autor:
James E. Trosko
Publikováno v:
Dose-Response, Vol 17 (2019)
To protect the public’s health from exposure to physical, chemical, and microbiological agents, it is important that any policy be based on rigorous scientifically based research. The concept of “linear no-threshold” (LNT) has been implemented
Externí odkaz:
https://doaj.org/article/958429eaa81641ae8853d35153be43d2
Autor:
James E. Trosko, Giuseppe Carruba
Publikováno v:
Dose-Response, Vol 15 (2017)
It has been proposed that many human cancers are generated by intrinsic mechanisms that produce “Bad Luck” mutations by the proliferation of organ-specific adult stem cells. There have been serious challenges to this interpretation, including mul
Externí odkaz:
https://doaj.org/article/9b9312b546fa4f408c27efc89554dc3e
Autor:
James E. Trosko
Publikováno v:
Carcinogenesis. 42:905-912
The ‘cancer stem cell’ hypothesis has pointed to a specific target for new cancer therapies. The hypothesis is based on the observation that only the ‘cancer stem cell’ among the other heterogeneous cancer cells can sustain the growth of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00c246e284ec37422d44c99e17c7441
https://doi.org/10.1093/carcin/bgab042
https://doi.org/10.1093/carcin/bgab042
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 13, p 3244 (2019)
Growing evidence suggests dietary antioxidants reduce the risk of several cancers. Grape seeds extracts (GSE) are a rich source of polyphenols known to have antioxidant, chemopreventive and anticancer properties. Herein, we investigated the in vitro
Externí odkaz:
https://doaj.org/article/0e576250c64d401c9d9c333bc2d2260a
Autor:
Frank Boelaert, Jean‐Louis Bresson, Anthony Hardy, George E. N. Kass, Pierluigi Nicotera, Anne Salonen, Richard M. Sharpe, James E. Trosko
Publikováno v:
EFSA Journal, Vol 14, Iss S1, Pp n/a-n/a (2016)
Abstract This session focused on emerging areas in biomedical research that are of key relevance to toxicology and, therefore, may influence EFSA's work. The impact on the way risk assessment is conducted in the area of food may be through the identi
Externí odkaz:
https://doaj.org/article/4b251f1741ab4663a92758beff28e6e2
Autor:
James E. Trosko
Publikováno v:
Diseases
Diseases, 9(4):68
Diseases, Vol 9, Iss 68, p 68 (2021)
Diseases, 9(4):68
Diseases, Vol 9, Iss 68, p 68 (2021)
Throughout the history of biological/medicine sciences, there has been opposing strategies to find solutions to complex human disease problems. Both empirical and deductive approaches have led to major insights and concepts that have led to practical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a660e0f368bb8c65f182e76d0d2492
http://europepmc.org/articles/PMC8544458
http://europepmc.org/articles/PMC8544458
Autor:
Iva Sovadinova, Pavel Babica, Hatice Böke, Esha Kumar, Andrew Wilke, Joon-Suk Park, James E Trosko, Brad L Upham
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0124454 (2015)
Dysregulation of gap junctional intercellular communication (GJIC) has been associated with different pathologies, including cancer; however, molecular mechanisms regulating GJIC are not fully understood. Mitogen Activated Protein Kinase (MAPK)-depen
Externí odkaz:
https://doaj.org/article/ec3ef4d1379c4f2bb2ff8ebdddea19bb
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 8977, p 8977 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 8977, p 8977 (2021)
Dysregulation of gap junction intercellular communication (GJIC) is recognized as one of the key hallmarks for identifying non-genotoxic carcinogens (NGTxC). Currently, there is a demand for in vitro assays addressing the gap junction hallmark, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f419a3adb3d16c2e435f6a01d83aa1ba
http://europepmc.org/articles/PMC8396440
http://europepmc.org/articles/PMC8396440