Cardiotoxic drugs Herceptin and doxorubicin inhibit cardiac microvascular endothelial cell barrier formation resulting in increased drug permeability

Autor: Emma L. Wilkinson, James E. Sidaway, Michael J. Cross

Publikováno v: Biology Open, Vol 5, Iss 10, Pp 1362-1370 (2016)

Cardiotoxicity induced by anti-cancer therapeutics is a severe, and potentially fatal, adverse reaction of the heart in response to certain drugs. Current in vitro approaches to assess cardiotoxicity have focused on analysing cardiomyocytes. More rec

Externí odkaz: https://doaj.org/article/cfc651f0eefb4c6b8dcf72d91b27fa3d

Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms

Autor: Rowena Sison-Young, Min Wei Wong, Chris S. Pridgeon, Michael J. Cross, Christopher E. Goldring, John Greenman, James E. Sidaway, Vitalina Gryshkova, Joseph Leedale, Paul Walker, Tahera Ansari, Emma L. Wilkinson, Laurence Launay, Susan Gibbs, B. Kevin Park, Tobias Heckel, Stefan Przyborski, R. N. Bearon, Constanze Schlott, Minne B. Heringa, Delilah F. G. Hendriks

Publikováno v: Pridgeon, C S, Schlott, C, Wong, M W, Heringa, M B, Heckel, T, Leedale, J, Launay, L, Gryshkova, V, Przyborski, S, Bearon, R N, Wilkinson, E L, Ansari, T, Greenman, J, Hendriks, D F G, Gibbs, S, Sidaway, J, Sison-Young, R L, Walker, P, Cross, M J, Park, B K & Goldring, C E P 2018, ' Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms ', Archives of Toxicology, vol. 92, no. 2, pp. 557-569 . https://doi.org/10.1007/s00204-018-2152-9
Archives of Toxicology

The development of improved, innovative models for the detection of toxicity of drugs, chemicals, or chemicals in cosmetics is crucial to efficiently bring new products safely to market in a cost-effective and timely manner. In addition, improvement

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abac4eb357d91a6ac35143bd8f1341eb
https://doi.org/10.1007/s00204-018-2152-9

Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury

Autor: Munir Pirmohamed, P J M Clements, Michael J. Cross, James E. Sidaway, Alan Norris, Laura Cove-Smith, Howard R. Mellor, M Holbrook, P Hoffmann, Alexander R. Lyon, Brian R. Berridge, Thomas Force, Jonathan Tugwood, B.K. Park

Publikováno v: British Journal of Pharmacology. 172:957-974

The incidence of drug-induced structural cardiotoxicity, which may lead to heart failure, has been recognized in association with the use of anthracycline anti-cancer drugs for many years, but has also been shown to occur following treatment with the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1a42b2c1f504ed84acc1d38c2ab3b60
https://doi.org/10.1111/bph.12979

Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury

Autor: Seyoum Ayehunie, Howard R. Mellor, Robert G. Vries, Alan Norris, Chris Probert, Alexander Penrose, Munir Pirmohamed, Shashi K. Ramaiah, B. Kevin Park, Alison Shaw, Andrea Davies, James E. Sidaway, Claire Sadler, Michael Schmitt, Syed A. Hussain, D. Mark Pritchard, Daniel F. Carr, Matthew Wagoner, Stephanie French, Carrie A. Duckworth, Neil Hall

Publikováno v: PHARMACOLOGY & THERAPEUTICS

Adverse drug reactions affecting the gastrointestinal (GI) tract are a serious burden on patients, healthcare providers and the pharmaceutical industry. GI toxicity encompasses a range of pathologies in different parts of the GI tract. However, to da

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::013fea942d2efe4f3854bdfe76704cec
https://pubmed.ncbi.nlm.nih.gov/28132905

Probiotic Administration Attenuates Myocardial Hypertrophy and Heart Failure After Myocardial Infarction in the Rat

Autor: Morris Karmazyn, Venkatesh Rajapurohitam, Gregory B. Gloor, James V. Haist, Glynn Martin, Grace Ettinger, Cathy Huang, Xiaohong Tracey Gan, Gregor Reid, Jonathan R. Swann, James E. Sidaway, Jeremy P. Burton

Publikováno v: Circulation: Heart Failure. 7:491-499

Background— Probiotics are extensively used to promote gastrointestinal health, and emerging evidence suggests that their beneficial properties can extend beyond the local environment of the gut. Here, we determined whether oral probiotic administr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f08ee1d6ed617d89c3d6e849d49862a
https://doi.org/10.1161/circheartfailure.113.000978