Zobrazeno 1 - 10
of 31
pro vyhledávání: '"James E, Brownell"'
Autor:
Xingyue He, Jessica Riceberg, Sai M Pulukuri, Steve Grossman, Vaishali Shinde, Pooja Shah, James E Brownell, Larry Dick, John Newcomb, Neil Bence
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123882 (2015)
SUMOylation is a post-translational ubiquitin-like protein modification pathway that regulates important cellular processes including chromosome structure, kinetochore function, chromosome segregation, nuclear and sub-nuclear organization, transcript
Externí odkaz:
https://doaj.org/article/13e1cfa28eb7421c9e7186a4338a176c
Autor:
James E. Brownell, Xiang Zhai
Publikováno v:
Trends in pharmacological sciences. 42(8)
KMT2 methyltransferases are important regulators of gene transcription through the methylation of histone H3 lysine 4 at promoter and enhancer regions. They reside in large, multisubunit protein complexes, which not only regulate their catalytic acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f98fc154b86f6ed5aa62cea249dfdb2
https://pubmed.ncbi.nlm.nih.gov/34074527
https://pubmed.ncbi.nlm.nih.gov/34074527
Autor:
Natalie Roy D’Amore, Shih-Chung Huang, Sharmila Adhikari, Dylan England, David Lok, Anna Lublinsky, Jouhara Chouitar, Klaudia Foley, Patrick J. LeRoy, Emily F. Calderwood, Ji Zhang, Alexandra E. Gould, James E. Brownell, Sean J. Harrison, Li-Ting Ma, Yu Yang, Saurabh Menon
Publikováno v:
Bioorganicmedicinal chemistry. 28(19)
Autophagy is postulated to be required by cancer cells to survive periods of metabolic and/or hypoxic stress. ATG7 is the E1 enzyme that is required for activation of Ubl conjugation pathways involved in autophagosome formation. This article describe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::656b64ba891d9a46f6ea1dbce3e38c14
https://pubmed.ncbi.nlm.nih.gov/32912429
https://pubmed.ncbi.nlm.nih.gov/32912429
Autor:
Stacey Price, Erica Banks, Hannah Thorpe, James E. Brownell, Matthias Pfeifer, Paul Smith, Jonathan S. Brammeld, Ultan McDermott, Shanade Dunn, Nin Guan, Aurélie Bornot, Maria Luisa Guerriero, Matthew J. Martin, James Pilling, Daniel O'Neill, Davide Gianni
Publikováno v:
Cancer Research. 81:1100-1100
10-20% of lung adenocarcinoma patients harbour activating mutations in EGFR. Although treatment with the EGFR kinase inhibitor osimertinib has improved overall survival in such patients, almost all patients ultimately develop drug resistance. In many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48b6070dc21a77a94ddac8f145eaa682
https://doi.org/10.1158/1538-7445.am2021-1100
https://doi.org/10.1158/1538-7445.am2021-1100
Autor:
James E. Brownell, C. David Allis
Publikováno v:
Biochim Biophys Acta Gene Regul Mech
Eukaryotic genomes are maintained within DNA-protein complexes called chromatin. Post-translational modification of chromatin proteins, and especially acetylation of the core histone amino-terminal tails, has long been associated with chromatin assem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e30c33e0be87ac72944d866b82a2517
https://doi.org/10.1016/j.bbagrm.2020.194605
https://doi.org/10.1016/j.bbagrm.2020.194605
Autor:
Sai M Pulukuri, James Minissale, Neil F. Bence, Matt Duffey, Hirotake Mizutani, He Xu, Hu Zhigen, Lawrence R. Dick, Xingyue He, Dylan England, Erik Koenig, Pooja Shah, Xiaofeng Yang, Hua Liao, Teresa A. Soucy, James E. Brownell, Melissa Gallery, Claudia Rabino, John Newcomb, Hugues Bernard, John Bradley, Jianping Guo, Mike Sintchak, Zhong-Hua Yan, Kristina Xega, Steve Langston, Ryan Chau, Jessica Riceberg, Eric S. Lightcap
Publikováno v:
Nature chemical biology. 13(11)
Small ubiquitin-like modifier (SUMO) family proteins regulate target-protein functions by post-translational modification. However, a potent and selective inhibitor targeting the SUMO pathway has been lacking. Here we describe ML-792, a mechanism-bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9174b996cee052b2dfda9c4bae1d2e1a
https://pubmed.ncbi.nlm.nih.gov/28892090
https://pubmed.ncbi.nlm.nih.gov/28892090
Autor:
Ping Li, Douglas Bowman, Helen He, Zhongmin Xiang, Zhi Li, Lunyin Yu, Natalie Roy D’Amore, James E. Brownell, Jie Yu, Jouhara Chouitar, Stephen Tirrell, Matthew Theisen, Yu Yang
Publikováno v:
Journal of Biomarkers
Objective. Use of tyramide signal amplification (TSA) to detect autophagy biomarkers in formalin fixed and paraffin embedded (FFPE) xenograft tissue. Materials and Methods. Autophagy marker regulation was studied in xenograft tissues using Amp HQ IHC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88fe472f04df222d8ded640bc561d0d9
http://europepmc.org/articles/PMC4877488
http://europepmc.org/articles/PMC4877488
Autor:
Lawrence R. Dick, Hua Liao, Neil Rollins, Xiaofeng Yang, William D. Mallender, Qing Xu, James E. Brownell, James M. Gavin, Jingyang Chen, Alexandra E. Gould, Huay-Keng Loke, Jingya Ma, Trupti Lingaraj, Benjamin S. Amidon
Publikováno v:
Journal of Biological Chemistry. 287:15512-15522
Uba6 is a homolog of the ubiquitin-activating enzyme, Uba1, and activates two ubiquitin-like proteins (UBLs), ubiquitin and FAT10. In this study, biochemical and biophysical experiments were performed to understand the mechanisms of how Uba6 recogniz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8390648a5c38612be09d427f5d03696
https://doi.org/10.1074/jbc.m111.336198
https://doi.org/10.1074/jbc.m111.336198
Autor:
Teresa A. Soucy, Peter G. Smith, Michael A. Milhollen, Allison J. Berger, James M. Gavin, Sharmila Adhikari, James E. Brownell, Kristine E. Burke, David P. Cardin, Stephen Critchley, Courtney A. Cullis, Amanda Doucette, James J. Garnsey, Jeffrey L. Gaulin, Rachel E. Gershman, Anna R. Lublinsky, Alice McDonald, Hirotake Mizutani, Usha Narayanan, Edward J. Olhava, Stephane Peluso, Mansoureh Rezaei, Michael D. Sintchak, Tina Talreja, Michael P. Thomas, Tary Traore, Stepan Vyskocil, Gabriel S. Weatherhead, Jie Yu, Julie Zhang, Lawrence R. Dick, Christopher F. Claiborne, Mark Rolfe, Joseph B. Bolen, Steven P. Langston
Publikováno v:
Nature. 458:732-736
The clinical development of an inhibitor of cellular proteasome function suggests that compounds targeting other components of the ubiquitin-proteasome system might prove useful for the treatment of human malignancies. NEDD8-activating enzyme (NAE) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f238daefd87e22eb7816dddaf60362e3
https://doi.org/10.1038/nature07884
https://doi.org/10.1038/nature07884
Autor:
James E. Brownell, Erik Koenig, Neil Rollins, Olga Tayber, Patrick J. LeRoy, Ping Li, Hugues Bernard, Jonathan Mandelbaum, Janice Y Lee, Pooja Shah, Doug Bowman, Natalie Roy D’Amore
Publikováno v:
Autophagy.
Autophagy is a major cellular process for bulk degradation of proteins and organelles in order to maintain metabolic homeostasis, and it represents an emerging target area for cancer. Initially proposed to be a cancer-restricting process for tumor in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84789a964ebffd24480dfe39be6284ba
https://pubmed.ncbi.nlm.nih.gov/26090719
https://pubmed.ncbi.nlm.nih.gov/26090719