Zobrazeno 1 - 3
of 3
pro vyhledávání: '"James Dvornicky"'
Autor:
Aadithya Kannan, Michael Chinn, Saeed Izadi, Andrew Maier, James Dvornicky, Mark Fedesco, Eric Day, Asif Ladiwala, Ann Woys
Publikováno v:
Journal of pharmaceutical sciences.
In the manufacturing of therapeutic monoclonal antibodies (mAbs), the final steps of the purification process are typically ultrafiltration/diafiltration (UF/DF), dilution, and conditioning. These steps are developed such that the final drug substanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052fc350c1a955bd6ea3a5d7411b42a0
https://pubmed.ncbi.nlm.nih.gov/36336103
https://pubmed.ncbi.nlm.nih.gov/36336103
Air sparging for prevention of antibody disulfide bond reduction in harvested CHO cell culture fluid
Autor:
Michael W. Laird, Melissa Mun, Melody Trexler-Schmidt, James Dvornicky, Yung-Hsiang Kao, Stefanie Khoo, Aline Do Minh
Publikováno v:
Biotechnology and Bioengineering. 112:734-742
During the scale-up of several Chinese Hamster Ovary (CHO) cell monoclonal antibody production processes, significant reduction of the antibody interchain disulfide bonds was observed. The reduction was correlated with excessive mechanical cell shear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ced097672e49e0a33ed5565ecfa502f2
https://doi.org/10.1002/bit.25495
https://doi.org/10.1002/bit.25495
Air sparging for prevention of antibody disulfide bond reduction in harvested CHO cell culture fluid
Autor:
Melissa, Mun, Stefanie, Khoo, Aline, Do Minh, James, Dvornicky, Melody, Trexler-Schmidt, Yung-Hsiang, Kao, Michael W, Laird
Publikováno v:
Biotechnology and bioengineering. 112(4)
During the scale-up of several Chinese Hamster Ovary (CHO) cell monoclonal antibody production processes, significant reduction of the antibody interchain disulfide bonds was observed. The reduction was correlated with excessive mechanical cell shear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e1d1f2c507f02d37bca28f6373180ba5
https://pubmed.ncbi.nlm.nih.gov/25384896
https://pubmed.ncbi.nlm.nih.gov/25384896