Zobrazeno 1 - 10
of 13
pro vyhledávání: '"James Dromey"'
Autor:
Danah Hourani, Simone Darling, Eloise Cameron, James Dromey, Louise Crossley, Sanji Kanagalingam, Frank Muscara, Amanda Gwee, Grace Gell, Harriet Hiscock, Vicki Anderson
Publikováno v:
Frontiers in Digital Health, Vol 3 (2021)
Embedding digital technologies in healthcare has the potential to streamline and personalize medical care. However, healthcare systems are often fragmented, and therefore achieving a truly integrated digital health program can be challenging. To prom
Externí odkaz:
https://doaj.org/article/5f4300a6d2254cb3ae872d39f9649fce
Autor:
Simone Reinwald, James Dromey, Esther Bandala-Sanchez, Yuxia Zhang, Leonard C. Harrison, Bo-Han Lee, Ralph M. Böhmer, Junyan Qian
Publikováno v:
Nature Immunology. 14:741-748
Functionally diverse T cell populations interact to maintain homeostasis of the immune system. We found that human and mouse antigen-activated T cells with high expression of the lymphocyte surface marker CD52 suppressed other T cells. CD52(hi)CD4(+)
Autor:
James Dromey, Kathryn L. Jones, Geza Paukovics, David J. Woollard, Magdalena Plebanski, Eric J. Gowans, Shuo Li
Publikováno v:
Immunology & Cell Biology. 85:197-204
The mechanism behind the apparent lack of effective antiviral immune responses in chronic hepatitis C virus (HCV) patients is poorly understood. It remains unclear if natural regulatory T cells (Treg) contribute to the induction and maintenance of HC
Autor:
James Dromey, Raymond J. Steptoe, Leonard C. Harrison, Katrina Ngui, Alana M. Neale, Grant Morahan, Kent P. Jensen, Bo Han Lee, Ole D. Madsen, Parth Narendran
Publikováno v:
Proceedings of the National Academy of Sciences. 103:16430-16435
Genes for peripheral tissue-restricted self-antigens are expressed in thymic and hematopoietic cells. In thymic medullary epithelial cells, self-antigen expression imposes selection on developing autoreactive T cells and regulates susceptibility to a
Autor:
Andrew L. Alexander, James Dromey, Andrew Tomlinson, Massimo Trucco, Elizabeth J. Stevens, Parth Narendran, Mark Peakman, Joan C. Gorga, Tobias Lohmann, Roman M. Chicz
Publikováno v:
Journal of Clinical Investigation. 104:1449-1457
During immune responses, antigen-presenting cells (APCs) process antigens and present peptide epitopes complexed with human leukocyte antigen (HLA) molecules. CD4 cells recognize these naturally processed and presented epitopes (NPPEs) bound to HLA c
Autor:
James Dromey, Daniel J. Thearle, Bo Han Lee, Leonard C. Harrison, Helen E. Young, Hua Yu, Stuart I. Mannering, Kent P. Jensen
Publikováno v:
Journal of autoimmunity. 36(1)
Autoantigen-specific regulatory T cells (Treg) are a potential cell therapy for human autoimmune disease, provided they could be generated in adequate numbers and with stable function. To this end, we determined the feasibility of cloning and expandi
Autor:
Arthur S. Tatham, James Dromey, Kate Henderson, Stuart I. Mannering, Carmen Gianfrani, Jessica Anne Stewart, Derek P. Jewell, Adrian V. S. Hill, David A. van Heel, Tim Beissbarth, Robert P. Anderson, Jason A. Tye-Din, James McCluskey, Jamie Rossjohn
Publikováno v:
Science translational medicine. 2(41)
Celiac disease is a genetic condition that results in a debilitating immune reaction in the gut to antigens in grain. The antigenic peptides recognized by the T cells that cause this disease are incompletely defined. Our understanding of the epitopes
Publikováno v:
International immunology. 19(4)
Studies on the thymic ontogeny of naturally arising CD4(+)CD25(+) regulatory T cells (TR cells) are complicated by the contamination of recirculating cells from the periphery (both activated CD4(+) T and TR cells). We investigated TR cells in anti-CD
Autor:
Daniel J. Thearle, Stuart I. Mannering, Kent P. Jensen, Jessica S. Morris, Leonard C. Harrison, James Dromey
Publikováno v:
Journal of immunological methods. 298(1-2)
T-cell clones are valuable tools for investigating T-cell specificity in infectious, autoimmune and malignant diseases. T cells specific for clinically-relevant autoantigens are difficult to clone using traditional methods. Here we describe an effici
Autor:
Bo Han Lee, James Dromey, Esther Bandala-Sanchez, Leonard C. Harrison, Simone Reinwald, Larissa Belov
Publikováno v:
Pathology. 42:S46-S47
Regulatory T cells (Tregs) suppress pro-inflammatory immune responses and prevent autoimmune disease. Many types of Tregs have been described, the prototypic in mice defined as CD4 +CD25 +with high expression of the Foxp3 transcription factor. Howeve