Zobrazeno 1 - 10
of 47
pro vyhledávání: '"James Dowden"'
Publikováno v:
'Biochemical Journal ', vol: 477, pages: 787-800 (2020)
Biochemical Journal
Biochemical Journal
Attenuating the function of protein arginine methyltransferases (PRMTs) is an objective for the investigation and treatment of several diseases including cardiovascular disease and cancer. Bisubstrate inhibitors that simultaneously target binding sit
Publikováno v:
Current Opinion in Green and Sustainable Chemistry. 35:100623
In this review, we consider green chemistry metrics, related software tools, and the opportunities and challenges for their use in research laboratories. We provide an overview of state-of-the-art software designed both to aid researchers in planning
Autor:
Bruner, James Dowden
Publikováno v:
PMLA, 1894 Jan 01. 9(4), 463-549.
Externí odkaz:
https://www.jstor.org/stable/456331
Publikováno v:
Organic letters. 19(23)
The iron (III) catalyzed synthesis of indolizines from commercially available alkyne, pyridine, and diazo precursors is reported. This mild, expedient method is tolerant of various solvents and proceeds with as little as 0.25 mol % [Fe(TPP)Cl]. Signi
Publikováno v:
ChemInform. 47
Commercially available iron(III) and copper(I) complexes catalyzed multicomponent cycloaddition reactions between diazo compounds, pyridines, and electrophilic alkenes to give alkaloid-inspired tetrahydroindolizidines in high yield with high diastere
The first total chemical synthesis of nicotinamide adenine dinucleotide phosphate (beta-NADP, 2) as a single isomer was achieved. This was subsequently converted into the important second messenger nicotinic acid adenine dinucleotide phosphate (p-NAA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12787761884fc5cd055c65db38b0c10e
https://ora.ox.ac.uk/objects/uuid:68dbab56-bacf-454d-8ce3-4c3a9927cc8a
https://ora.ox.ac.uk/objects/uuid:68dbab56-bacf-454d-8ce3-4c3a9927cc8a
Publikováno v:
Angewandte Chemie (International ed. in English). 55(19)
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Commercially available iron(III) and copper(I) complexes catalyzed multicomponent cycloaddition reactions between diazo compounds, pyridines, and electrophilic alkenes to give alkaloid-inspired tetr
Autor:
Stephen Bartlett, Carrie Anderson, Jonathan D. Gitlin, Duncan Wilson, Robert N. Kelsh, Ling He, John M. Gansner, James Dowden
Publikováno v:
Molecular Biosystems
Zebrafish embryos exposed to 2-mercaptopyridine-N-oxide (MCP) develop an undulated notochord in positions that correlate to the period of exposure. Further studies suggest that lysyl oxidase is the molecular target of MCP.
As a result of a chemi
As a result of a chemi
Autor:
Maliha Uroos, Magnus W. D. Hanson-Heine, James Dowden, Thomas Murphy, James A. Calladine, Ian P. Clark, Alisdair Wriglesworth, Michael W. George, Michael Towrie, Michelle L. Hamilton, Nicholas A. Besley
In contrast to the ground state, the calculation of the infrared (IR) spectroscopy of molecular singlet excited states represents a substantial challenge. Here we use the structural IR fingerprint of the singlet excited states of a range of coumarin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a16350da46d56c0ddbd9353e246e118
https://eprints.nottingham.ac.uk/29967/1/JCP-coumarin.pdf
https://eprints.nottingham.ac.uk/29967/1/JCP-coumarin.pdf
Autor:
Georgina Berridge, Christelle Moreau, James Dowden, Barry V. L. Potter, Grant C. Churchill, Antony Galione, Michiko Yamasaki
Publikováno v:
Chemistry & Biology. 13(6):659-665
Summary Nicotinic acid adenine dinucleotide phosphate (NAADP, 1 ) is the most potent intracellular Ca 2+ mobilizing agent in important mammalian cells and tissues, yet the identity of the NAADP receptor is elusive. Significantly, the coenzyme NADP is