Zobrazeno 1 - 10
of 47
pro vyhledávání: '"James DiNunzio"'
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 164:28-35
Measuring the solubility of a crystalline active pharmaceutical ingredient (API) in a polymer-rich system is challenging due to the high viscosity of the polymer which kinetically impedes reaching the solubility equilibrium. In this study, a rheologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a8ba1e7550a4c691d91e25555ba41d7
https://doi.org/10.1016/j.ejpb.2021.04.015
https://doi.org/10.1016/j.ejpb.2021.04.015
Autor:
Adam Procopio, Akhilesh Bhambhani, Brian K. Meyer, Kristin J. M. Ploeger, Robert F. Meyer, Yash Kapoor, Erin N. Guidry, Allen C. Templeton, James DiNunzio, Justin Stanbro, Gregory M. Troup
Publikováno v:
Journal of Pharmaceutical Innovation. 16:2-10
Flexible manufacturing systems are needed in the pharmaceutical industry due to the future challenges of volatility, uncertainty, complexity, and ambiguity [1]. Compared to traditional manufacturing systems that dominate the pharmaceutical industry t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::beb0fc19ee88abd93f114adb447c5ad8
https://doi.org/10.1007/s12247-019-09426-z
https://doi.org/10.1007/s12247-019-09426-z
Autor:
Johannes Khinast, Stephan Sacher, Benjamin J. Glasser, M. Sebastian Escotet-Espinoza, Jakob Rehrl, James DiNunzio, Sara Fathollahi, Julia Kruisz
Publikováno v:
AAPS PharmSciTech
This paper proposes a feed rate control strategy for a novel volumetric micro-feeder, which can accomplish low-dose feeding of pharmaceutical raw materials with significantly different powder properties. The developed feed-forward control strategy en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a040c90cb905f7b2c37c11f5229aee
https://doi.org/10.1208/s12249-021-02104-9
https://doi.org/10.1208/s12249-021-02104-9
Autor:
Adam Socia, Brian P. Regler, James DiNunzio, Runqiao Dong, Walter Wasylaschuk, J. Axel Zeitler
Publikováno v:
Pharmaceutics, Vol 13, Iss 933, p 933 (2021)
Pharmaceutics
Volume 13
Issue 7
Pharmaceutics
Volume 13
Issue 7
The kinetics of water transport into tablets, and how it can be controlled by the formulation as well as the tablet microstructure, are of central importance in order to design and control the dissolution and drug release process, especially for imme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc16836a83e0a10efbc4bd8a69e9c051
https://www.mdpi.com/1999-4923/13/7/933
https://www.mdpi.com/1999-4923/13/7/933
Autor:
M. Sebastian Escotet-Espinoza, Sara Fathollahi, Stephan Sacher, Johannes Khinast, James DiNunzio
Publikováno v:
AAPS PharmSciTech
Abstract Highly potent active pharmaceutical ingredients (APIs) and low-dose excipients, or excipients with very low density, are notoriously hard to feed with currently available commercial technology. The micro-feeder system presented in this work
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3851fffcd1f14fb6c46957a862d1782
https://pubmed.ncbi.nlm.nih.gov/33141336
https://pubmed.ncbi.nlm.nih.gov/33141336
Autor:
James H. Small, Fengyuan Yang, Chengbin Huang, Yongchao Su, Chad D. Brown, Andrew M. Farrington, James DiNunzio, Gary E. Martin
Publikováno v:
Pharmaceutical Research. 37
An investigation of underlying mechanisms of API-polymer interaction patterns has the potential to provide valuable insights for selecting appropriate formulations with superior physical stability and processability.In this study, copovidone was used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::819f79b402f42d2eacb641a88ee7c03f
https://doi.org/10.1007/s11095-020-02813-z
https://doi.org/10.1007/s11095-020-02813-z
Autor:
Haichen Nie, Patrick J. Marsac, Yongchao Su, Hang Lau, Nico Setiawan, Lynne S. Taylor, Matthew K. Defrese, Jonas Alin, James DiNunzio, Hanmi Xi, Nathan Hesse, Lisa Lupton
Publikováno v:
Polymer. 135:50-60
The utility of amorphization of drug molecules, such as enhanced solubility, dissolution rate and oral bioavailability, has been well exemplified in the literature. Yet, the application of this technique is often hindered by the crystallization liabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2579c68485d1841a71e5ed4bbec19b5a
https://doi.org/10.1016/j.polymer.2017.11.056
https://doi.org/10.1016/j.polymer.2017.11.056
Autor:
Lawrence De Belder, Hung-Ren Homer Lin, Ian Leavesley, Gurjit Bajwa, Ahmad Almaya, Dan Blackwood, Admassu Abebe, Jayanthy Jayanth, Anthony Tantuccio, Karthik Nagapudi, James DiNunzio, Robert F. Meyer
Publikováno v:
Journal of Pharmaceutical Sciences. 106:930-943
Continuous manufacturing (CM) has emerged in the pharmaceutical industry as a paradigm shift with significant advantages related to cost, efficiency, flexibility, and higher assurance of quality. The inherent differences from batch processes justify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e93608de3e20f44f81cd14777fad93
https://doi.org/10.1016/j.xphs.2016.12.014
https://doi.org/10.1016/j.xphs.2016.12.014
Autor:
Chengbin Huang, Jingtao Zhang, James DiNunzio, Chad D. Brown, Fengyuan Yang, Yongchao Su, Anthony Leone
Publikováno v:
Molecular Pharmaceutics. 13:3494-3505
The production of amorphous solid dispersions via hot melt extrusion (HME) relies on elevated temperature and prolonged residence time, which can result in potential degradation and decomposition of thermally sensitive components. Herein, the rheolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4dcb547da7efa0d5da0a7a956e45fb3
https://doi.org/10.1021/acs.molpharmaceut.6b00516
https://doi.org/10.1021/acs.molpharmaceut.6b00516
The first edition of Pharmaceutical Extrusion Technology, published in 2003, was deemed the seminal book on pharmaceutical extrusion. Now it is expanded and improved, just like the usage of extrusion has expanded, improved and evolved into an accepte
