Zobrazeno 1 - 10
of 14
pro vyhledávání: '"James Delproposto"'
Autor:
Alfredo J Guerra, Ou Zhang, Constance M E Bahr, My-Hang Huynh, James DelProposto, William C Brown, Zdzislaw Wawrzak, Nicole M Koropatkin, Vern B Carruthers
Publikováno v:
PLoS Pathogens, Vol 14, Iss 12, p e1007476 (2018)
Intracellular pathogens must egress from the host cell to continue their infectious cycle. Apicomplexans are a phylum of intracellular protozoans that have evolved members of the membrane attack complex and perforin (MACPF) family of pore forming pro
Externí odkaz:
https://doaj.org/article/a4c1cc508abb4092b26750a4c84d4163
Autor:
Chao-Yie Yang, James Delproposto, Krishnapriya Chinnaswamy, William Clay Brown, Shuying Wang, Jeanne A Stuckey, Xinquan Wang
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146522 (2016)
Suppression of Tumorigenicity 2 (ST2), a member of the interleukin-1 receptor (IL-1R) family, activates type 2 immune responses to pathogens and tissue damage via binding to IL-33. Dysregulated responses contribute to asthma, graft-versus-host and au
Externí odkaz:
https://doaj.org/article/6a9f5aa11f554fa3802a36c1e0896b68
Autor:
Daniel F. Hayes, James Delproposto, Mingliang Wang, Bukeyan Miao, Biao Hu, Shaomeng Wang, Jiantao Hu, Chao Yie Yang, Krishnapriya Chinnaswamy, Jeanne A. Stuckey, Fuming Xu, Zhaomin Liu, Mi Wang
Publikováno v:
Journal of Medicinal Chemistry. 62:1420-1442
The estrogen receptor (ER) is a validated target for the treatment of estrogen receptor-positive (ER+) breast cancer. Here, we describe the design, synthesis, and extensive structure-activity relationship (SAR) studies of small-molecule ERα degrader
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6151fe4fbd0bc7e74b7395591f00c3
https://doi.org/10.1021/acs.jmedchem.8b01572
https://doi.org/10.1021/acs.jmedchem.8b01572
Autor:
Shaomeng Wang, Denzil Bernard, Shilin Xu, James Delproposto, Ester Fernandez-Salas, Liyue Huang, Kaitlin Harvey, Jeff W. Kampf, Liu Liu, Angelo Aguilar, Jeanne A. Stuckey, Tianfeng Xu, Caroline Foster, Donna McEachern, Ke Zheng, Krishnapriya Chinnaswamy
Publikováno v:
J Med Chem
Inhibition of the menin-mixed lineage leukemia (MLL) protein-protein interaction is a promising new therapeutic strategy for the treatment of acute leukemia carrying MLL fusion (MLL leukemia). We describe herein our structure-based design, synthesis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f788880b5caa42734c0f09b97f52f68
https://pubmed.ncbi.nlm.nih.gov/31244110
https://pubmed.ncbi.nlm.nih.gov/31244110
Autor:
James Delproposto, Tianfeng Xu, Jeanne A. Stuckey, Krishnapriya Chinnaswamy, Weiguo Xiang, Chong Qin, Shaomeng Wang, Lijie Zhao, Ester Fernandez-Salas, Chao Wang, Xin Han, Chao Yie Yang, Mi Wang
Publikováno v:
Journal of medicinal chemistry. 62(2)
We report herein the discovery of highly potent PROTAC degraders of androgen receptor (AR), as exemplified by compound 34 (ARD-69). ARD-69 induces degradation of AR protein in AR-positive prostate cancer cell lines in a dose- and time-dependent manne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa48cb63c08eeff567789b50ecd723e1
https://pubmed.ncbi.nlm.nih.gov/30629437
https://pubmed.ncbi.nlm.nih.gov/30629437
Autor:
Ou Zhang, James Delproposto, Constance M. Bahr, Alfredo J. Guerra, Nicole M. Koropatkin, Zdzislaw Wawrzak, William C. Brown, Vern B. Carruthers, My Hang Huynh
Publikováno v:
PLoS Pathogens, Vol 14, Iss 12, p e1007476 (2018)
PLoS Pathogens
PLoS Pathogens
Intracellular pathogens must egress from the host cell to continue their infectious cycle. Apicomplexans are a phylum of intracellular protozoans that have evolved members of the membrane attack complex and perforin (MACPF) family of pore forming pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f892c34707a4f8ea41b377b1d3b87f61
https://doi.org/10.1101/399204
https://doi.org/10.1101/399204
Autor:
James Delproposto, Carrie Rollins, Jeffrey D. Levengood, Jennifer L. Meagher, Christopher E. Morgan, Jeanne A. Stuckey, Blanton S. Tolbert
Publikováno v:
Journal of Molecular Biology. 427:3241-3257
The heterogeneous nuclear ribonucleoprotein (hnRNP) A1 protein is a multifunctional RNA binding protein implicated in a wide range of biological functions. Mechanisms and putative hnRNP A1-RNA interactions have been inferred primarily from the crysta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5142abe35492057c64b9804016a3cf7
https://doi.org/10.1016/j.jmb.2015.05.009
https://doi.org/10.1016/j.jmb.2015.05.009
Autor:
Haiying Sun, William Clay Brown, Krishnapriya Chinnaswamy, James G. Phillips, James Delproposto, Jeanne A. Stuckey, Longchuan Bai, Chao Yie Yang
Aberrant activation of the complement system is associated with diseases, including paroxysmal nocturnal hemoglobinuria and age-related macular degeneration. Complement factor D is the rate-limiting enzyme for activating the alternative pathway in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::687bcbbc454d090a0084e2a2380d20b8
https://europepmc.org/articles/PMC5151139/
https://europepmc.org/articles/PMC5151139/
Autor:
Oleg V. Tsodikov, Sylvie Garneau-Tsodikova, James Delproposto, Thomas J. McQuade, Anita Sheoran, Abbie D. Shallop
Publikováno v:
Analytical Biochemistry. 386:244-250
Adenylation domains are critical enzymes that dictate the identity of the amino acid building blocks to be incorporated during nonribosomal peptide (NRP) biosynthesis. NRPs display a wide range of biological activities and are some of the most import
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3cc158afc74ba05c1ce8efe7b419519
https://doi.org/10.1016/j.ab.2008.12.014
https://doi.org/10.1016/j.ab.2008.12.014
Publikováno v:
Protein Expression and Purification. 63:40-49
A persistent problem in heterologous protein production is insolubility of the target protein when expressed to high level in the host cell. A widely employed strategy for overcoming this problem is the use of fusion tags. The best fusion tags promot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e023efc9eb17227811e503f419d0605
https://doi.org/10.1016/j.pep.2008.08.011
https://doi.org/10.1016/j.pep.2008.08.011