Zobrazeno 1 - 10
of 277
pro vyhledávání: '"James DeGregori"'
Autor:
Yan Cui, Kai Wang, Danli Jiang, Yizhou Jiang, Dawei Shi, James DeGregori, Samuel Waxman, Ruibao Ren
Publikováno v:
Aging and Cancer, Vol 4, Iss 3-4, Pp 111-120 (2023)
Abstract Aging and cancer are increasingly becoming big challenges for public health worldwide due to increased human life expectancy. Meanwhile, aging is one of the major risk factors for cancer. In December 2019, the first International Conference
Externí odkaz:
https://doaj.org/article/90c46b7aec2b4b25a1ac3413454188a0
Autor:
Jean‐Pascal Capp, Frédéric Thomas, Andriy Marusyk, Antoine M. Dujon, Sophie Tissot, Robert Gatenby, Benjamin Roche, Beata Ujvari, James DeGregori, Joel S. Brown, Aurora M. Nedelcu
Publikováno v:
Evolutionary Applications, Vol 16, Iss 7, Pp 1239-1256 (2023)
Abstract It is traditionally assumed that during cancer development, tumor cells abort their initially cooperative behavior (i.e., cheat) in favor of evolutionary strategies designed solely to enhance their own fitness (i.e., a “selfish” life sty
Externí odkaz:
https://doaj.org/article/40f663a816d647f3bbcfcd57342f99de
Autor:
Fabio Marongiu, James DeGregori
Publikováno v:
Molecular Oncology, Vol 16, Iss 18, Pp 3238-3258 (2022)
Aging represents the major risk factor for the development of cancer and many other diseases. Recent findings show that normal tissues become riddled with expanded clones that are frequently driven by cancer‐associated mutations in an aging‐depen
Externí odkaz:
https://doaj.org/article/4b794a98bd4d4e10a91080afb90bc231
Autor:
Dejana Braithwaite, Stephen Anton, Supriya Mohile, James DeGregori, Nancy Gillis, Daohong Zhou, Shirley Bloodworth, Marco Pahor, Jonathan Licht
Publikováno v:
Aging and Cancer, Vol 3, Iss 2, Pp 87-94 (2022)
Abstract Background The intersection of cancer and aging is an emerging public health challenge in developed countries because of the aging and expansion of the population. Aims We convened a panel of experts to share their insights on this topic at
Externí odkaz:
https://doaj.org/article/0b07fe03ee8941b28f96ab8e71af1107
Autor:
Edward J. Evans Jr., James DeGregori
Publikováno v:
Aging and Cancer, Vol 2, Iss 3, Pp 82-97 (2021)
Abstract Background To shed light on the earliest events in oncogenesis, there is growing interest in understanding the mutational landscapes of normal tissues across ages. In the last decade, next‐generation sequencing of human tissues has reveale
Externí odkaz:
https://doaj.org/article/40f84d41246441d7a884f64d7c91cdee
Autor:
Hae J Park, Mark A Gregory, Vadym Zaberezhnyy, Andrew Goodspeed, Craig T Jordan, Jeffrey S Kieft, James DeGregori
Publikováno v:
eLife, Vol 11 (2022)
While leukemic cells are susceptible to various therapeutic insults, residence in the bone marrow microenvironment typically confers protection from a wide range of drugs. Thus, understanding the unique molecular changes elicited by the marrow is of
Externí odkaz:
https://doaj.org/article/ea84268fcc014d5baa026f0532c4b188
Autor:
Edward J. Evans Jr., James DeGregori
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 14 (2022)
Individuals with Down syndrome (DS) have more than 100-fold increased risk of acute megakaryoblastic leukemia (AMKL), but its pathogenesis is poorly understood. In this issue of the JCI, Arkoun et al. engineered stepwise DS-AMKL–associated mutation
Externí odkaz:
https://doaj.org/article/0dfbe371037648eda4455fe9f9817eb5
Autor:
Daniel Promislow, Rozalyn M. Anderson, Marten Scheffer, Bernard Crespi, James DeGregori, Kelley Harris, Barbara Natterson Horowitz, Morgan E. Levine, Maria A. Riolo, David S. Schneider, Sabrina L. Spencer, Dario Riccardo Valenzano, Michael E. Hochberg
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104199- (2022)
Summary: Aging research is unparalleled in the breadth of disciplines it encompasses, from evolutionary studies examining the forces that shape aging to molecular studies uncovering the underlying mechanisms of age-related functional decline. Despite
Externí odkaz:
https://doaj.org/article/b80faeaf247e401282c9a01788bd15ad
Autor:
Antoine M. Dujon, Athena Aktipis, Catherine Alix‐Panabières, Sarah R. Amend, Amy M. Boddy, Joel S. Brown, Jean‐Pascal Capp, James DeGregori, Paul Ewald, Robert Gatenby, Marco Gerlinger, Mathieu Giraudeau, Rodrigo K. Hamede, Elsa Hansen, Irina Kareva, Carlo C. Maley, Andriy Marusyk, Nicholas McGranahan, Michael J. Metzger, Aurora M. Nedelcu, Robert Noble, Leonard Nunney, Kenneth J. Pienta, Kornelia Polyak, Pascal Pujol, Andrew F. Read, Benjamin Roche, Susanne Sebens, Eric Solary, Kateřina Staňková, Holly Swain Ewald, Frédéric Thomas, Beata Ujvari
Publikováno v:
Evolutionary Applications, Vol 14, Iss 4, Pp 877-892 (2021)
Abstract The application of evolutionary and ecological principles to cancer prevention and treatment, as well as recognizing cancer as a selection force in nature, has gained impetus over the last 50 years. Following the initial theoretical approach
Externí odkaz:
https://doaj.org/article/89d15c8bc6dc4e8fb594eb56f0fd801f
Autor:
James DeGregori
Publikováno v:
Evolutionary Applications, Vol 13, Iss 7, Pp 1784-1790 (2020)
Abstract This special issue of evolutionary applications focused on the evolution of cancer has provided a wealth of different viewpoints and results from leaders in the field. Together, these papers emphasize the importance of a broad perspective in
Externí odkaz:
https://doaj.org/article/dc5e8a49a32e4387baa8903d94eb0518