Zobrazeno 1 - 10
of 88
pro vyhledávání: '"James D. Zieske"'
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Abstract Keratoconus (KC) is classically considered a non-inflammatory condition caused by central corneal thinning that leads to astigmatism and reduced visual acuity. Previous studies have identified increased systemic levels of pro-inflammatory fa
Externí odkaz:
https://doaj.org/article/d96b5ffa0eba4fe19fb04ba77f65b757
Autor:
Tina B. McKay, Vincent Yeung, Audrey E. K. Hutcheon, Xiaoqing Guo, James D. Zieske, Joseph B. Ciolino
Publikováno v:
Analytical Cellular Pathology, Vol 2021 (2021)
Extracellular vesicles (EVs) are phospholipid bilayer-bound particles secreted by cells that have been found to be important in mediating cell-cell communication, signal transduction, and extracellular matrix remodeling. Their role in both physiologi
Externí odkaz:
https://doaj.org/article/ff0dc14c539648c4aab6c6d0bf66ef3f
Autor:
Vincent Yeung, Sriniwas Sriram, Jennifer A. Tran, Xiaoqing Guo, Audrey E. K. Hutcheon, James D. Zieske, Dimitrios Karamichos, Joseph B. Ciolino
Publikováno v:
Biomolecules, Vol 11, Iss 11, p 1682 (2021)
Corneal fibrosis (or scarring) occurs in response to ocular trauma or infection, and by reducing corneal transparency, it can lead to visual impairment and blindness. Studies highlight important roles for transforming growth factor (TGF)-β1 and -β3
Externí odkaz:
https://doaj.org/article/392e63b66603462983e9326a3b179321
Publikováno v:
Cells, Vol 9, Iss 5, p 1080 (2020)
The corneal epithelium mediates the initial response to injury of the ocular surface and secretes a number of profibrotic factors that promote corneal scar development within the stroma. Previous studies have shown that corneal epithelial cells also
Externí odkaz:
https://doaj.org/article/ba3ee2da38a74ce8a3f5826b2e70e27e
Autor:
James D. Zieske, Audrey E.K. Hutcheon, Xiaoqing Guo, Dimitrios Karamichos, Ramin Zareian, Jeffrey W. Ruberti
Publikováno v:
Journal of Functional Biomaterials, Vol 3, Iss 4, Pp 760-775 (2012)
Keratoconus is a disease where the cornea becomes cone-like due to structural thinning and ultimately leads to compromised corneal integrity and loss of vision. Currently, the therapeutic options are corrective lenses for early stages and surgery for
Externí odkaz:
https://doaj.org/article/cebfacaf73724b0c948fa9fcc855e1e6
Autor:
Biagio Saitta, Vickery Trinkaus-Randall, Ruiyi Ren, Dimitrios Karamichos, Audrey E.K. Hutcheon, Celeste B. Rich, James D. Zieske
Publikováno v:
Journal of Functional Biomaterials, Vol 2, Iss 3, Pp 213-229 (2011)
Corneal integrity is critical for vision. Corneal wounds frequently heal with scarring that impairs vision. Recently, human umbilical cord mesenchymal stem cells (cord stem cells) have been investigated for tissue engineering and therapy due to their
Externí odkaz:
https://doaj.org/article/6d4f149bcefd4ae0acb7acd2ba9b0b0a
Publikováno v:
Eye (Lond)
Corneal fibrosis develops in response to injury, infection, postsurgical complications, or underlying systemic disease that disrupts the homeostasis of the tissue leading to irregular extracellular matrix deposition within the stroma. The mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::420718074991c0e6a1cfe05cede21d11
https://doi.org/10.1038/s41433-019-0736-0
https://doi.org/10.1038/s41433-019-0736-0
Autor:
Jennifer A Tran, Audrey E. K. Hutcheon, Dimitrios Karamichos, Joseph B. Ciolino, Sriniwas Sriram, Vincent Yeung, James D. Zieske, Xiaoqing Guo
Publikováno v:
Biomolecules, Vol 11, Iss 1682, p 1682 (2021)
Biomolecules
Volume 11
Issue 11
Biomolecules
Volume 11
Issue 11
Corneal fibrosis (or scarring) occurs in response to ocular trauma or infection, and by reducing corneal transparency, it can lead to visual impairment and blindness. Studies highlight important roles for transforming growth factor (TGF)-β1 and -β3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f621f312a9b5edb00ccd5dbdc2ea8765
https://www.mdpi.com/2218-273X/11/11/1682
https://www.mdpi.com/2218-273X/11/11/1682
Publikováno v:
Exp Eye Res
Corneal endothelium is a cellular monolayer positioned on the Descemet's membrane at the anterior cornea, and it plays a critical role in maintaining corneal clarity. Our present study examines the feasibility of utilizing our 3-dimensional (3D) corn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1aa72444f146b7142a8b37a75fcded
https://doi.org/10.1016/j.exer.2019.04.003
https://doi.org/10.1016/j.exer.2019.04.003
Autor:
Dimitrios Karamichos, Martha L Funderburgh, Audrey E K Hutcheon, James D Zieske, Yiqin Du, Jian Wu, James L Funderburgh
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86260 (2014)
Human corneal fibroblasts (HCF) and corneal stromal stem cells (CSSC) each secrete and organize a thick stroma-like extracellular matrix in response to different substrata, but neither cell type organizes matrix on tissue-culture polystyrene. This st
Externí odkaz:
https://doaj.org/article/4f22a287093149a5b9ae17010254e9ec