Zobrazeno 1 - 10
of 38
pro vyhledávání: '"James D. West"'
Autor:
Lars Kaduhr, Cindy Brachmann, Keerthiraju Ethiraju Ravichandran, James D. West, Sebastian Glatt, Raffael Schaffrath
Publikováno v:
Microbial Cell, Vol 8, Iss 11, Pp 256-261 (2021)
Ubiquitin related modifier 1 (Urm1) is a unique eukaryotic member of the ubiquitin-fold (UbF) protein family and conserved from yeast to humans. Urm1 is dual-functional, acting both as a sulfur carrier for thiolation of tRNA anticodons and as a prote
Externí odkaz:
https://doaj.org/article/0d80428e3e4f429ba163e7e80e12d319
Autor:
Vineet Agrawal, Anna R. Hemnes, Nicholas J. Shelburne, Niki Fortune, Julio L. Fuentes, Dan Colvin, Marion W. Calcutt, Megha Talati, Emily Poovey, James D. West, Evan L. Brittain
Publikováno v:
Pulmonary Circulation, Vol 12, Iss 3, Pp n/a-n/a (2022)
Abstract Pulmonary arterial hypertension (PAH) is a fatal vasculopathy that ultimately leads to elevated pulmonary pressure and death by right ventricular (RV) failure, which occurs in part due to decreased fatty acid oxidation and cytotoxic lipid ac
Externí odkaz:
https://doaj.org/article/5f982da54b464a12a0b70bc83b5a374f
Autor:
Thomas Bertero, Yu Lu, Sofia Annis, Andrew Hale, Balkrishen Bhat, Rajan Saggar, Rajeev Saggar, W. Dean Wallace, David J. Ross, Sara O. Vargas, Brian B. Graham, Rahul Kumar, Stephen M. Black, Sohrab Fratz, Jeffrey R. Fineman, James D. West, Kathleen J. Haley, Aaron B. Waxman, B. Nelson Chau, Katherine A. Cottrill, Stephen Y. Chan
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)
Externí odkaz:
https://doaj.org/article/f75ae1b920ed4388b4b98edd05c4de18
Autor:
Anandharajan Rathinasabapathy, Courtney Copeland, Amber Crabtree, Erica J. Carrier, Christy Moore, Sheila Shay, Santhi Gladson, Eric D. Austin, Anne K. Kenworthy, James E. Loyd, Anna R. Hemnes, James D. West
Publikováno v:
Frontiers in Medicine, Vol 7 (2020)
Background: In 2012, mutations in Cav1 were found to be the driving mutation in several cases of heritable pulmonary arterial hypertension (PAH). These mutations replaced the last 21 amino acids of Cav1 with a novel 22-amino-acid sequence. Because pr
Externí odkaz:
https://doaj.org/article/e861367abae04f8cb4d336d24298a2b1
Autor:
Cindy Brachmann, Lars Kaduhr, André Jüdes, Keerthiraju Ethiraju Ravichandran, James D. West, Sebastian Glatt, Raffael Schaffrath
Publikováno v:
Redox Biology, Vol 30, Iss , Pp - (2020)
The yeast peroxiredoxin Ahp1, like related anti-oxidant enzymes in other species, undergoes urmylation, a lysine-directed conjugation to ubiquitin-like modifier Urm1. Ahp1 assembles into a homodimer that detoxifies peroxides via forming intersubunit
Externí odkaz:
https://doaj.org/article/f70f5888cbee42e685f95f43aa9245d5
Autor:
Vineet Agrawal, Niki Fortune, Sheeline Yu, Julio Fuentes, Fubiao Shi, David Nichols, Linda Gleaves, Emily Poovey, Thomas J. Wang, Evan L. Brittain, Sheila Collins, James D. West, Anna R. Hemnes
Publikováno v:
Pulmonary Circulation, Vol 9 (2019)
Heart failure with preserved ejection fraction (HFpEF) currently has no therapies that improve mortality. Right ventricular dysfunction and pulmonary hypertension are common in HFpEF, and thought to be driven by obesity and metabolic syndrome. Thus,
Externí odkaz:
https://doaj.org/article/5d105d71b22f48f3af7f3fc4cde41f3d
Autor:
James D. West, Cristi L. Galindo, Kyungsoo Kim, John Jonghyun Shin, James B. Atkinson, Ines Macias‐Perez, Leo Pavliv, Bjorn C. Knollmann, Jonathan H. Soslow, Larry W. Markham, Erica J. Carrier
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 21 (2019)
Background Muscular dystrophy (MD) causes a progressive cardiomyopathy characterized by diffuse fibrosis, arrhythmia, heart failure, and early death. Activation of the thromboxane‐prostanoid receptor (TPr) increases calcium transients in cardiomyoc
Externí odkaz:
https://doaj.org/article/95214a90e2ad4dbbb0a6b21eedf73060
Autor:
Nils P. Nickel, Vinicio A. de Jesus Perez, Roham T. Zamanian, Joshua P. Fessel, Joy D. Cogan, Rizwam Hamid, James D. West, Mark P. de Caestecker, Haichun Yang, Eric D. Austin
Publikováno v:
Pulmonary Circulation, Vol 9 (2019)
Low-grade albuminuria, determined by the urinary albumin to creatinine ratio, has been linked to systemic vascular dysfunction and is associated with cardiovascular mortality. Pulmonary arterial hypertension is related to mutations in the bone morpho
Externí odkaz:
https://doaj.org/article/41e91f5e51a94149aa05ac094a5a7996
Autor:
Andrew J. Bryant, Chunhua Fu, Yuanquing Lu, Mark L. Brantly, Borna Mehrad, Lyle L. Moldawer, Todd M. Brusko, Evan L. Brittain, James D. West, Eric D. Austin, Rizwan Hamid
Publikováno v:
Pulmonary Circulation, Vol 9 (2019)
Externí odkaz:
https://doaj.org/article/83b4b142c41c4478b870dcd0849de48a
Autor:
James D. West, Eric D. Austin, Elise M. Rizzi, Ling Yan, Harikrishna Tanjore, Amber L. Crabtree, Christy S. Moore, Gladson Muthian, Erica J. Carrier, David A. Jacobson, Rizwan Hamid, Peggy L. Kendall, Susan Majka, Anandharajan Rathinasabapathy
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 5014 (2021)
Loss of function KCNK3 mutation is one of the gene variants driving hereditary pulmonary arterial hypertension (PAH). KCNK3 is expressed in several cell and tissue types on both membrane and endoplasmic reticulum and potentially plays a role in multi
Externí odkaz:
https://doaj.org/article/72de54ae655f451f83594e429146876f