S-Nitrosylated hemoglobin predicts organ yield in neurologically-deceased human donors

Autor: Ryan Nazemian, Maroun Matta, Amer Aldamouk, Lin Zhu, Mohamed Awad, Megan Pophal, Nicole R. Palmer, Tonya Armes, Alfred Hausladen, Jonathan S. Stamler, James D. Reynolds

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-7 (2022)

Abstract Current human donor care protocols following death by neurologic criteria (DNC) can stabilize macro-hemodynamic parameters but have minimal ability to preserve systemic blood flow and microvascular oxygen delivery. S-nitrosylated hemoglobin

Externí odkaz: https://doaj.org/article/74a4b1c6ee4b4d37b7fb5f4398f4978e

Airway Thiol-NO Adducts as Determinants of Exhaled NO

Autor: Megan Pophal, Zachary W. Grimmett, Clara Chu, Seunghee Margevicius, Thomas Raffay, Kristie Ross, Anjum Jafri, Olivia Giddings, Jonathan S. Stamler, Benjamin Gaston, James D. Reynolds

Publikováno v: Antioxidants, Vol 10, Iss 10, p 1527 (2021)

Thiol-NO adducts such as S-nitrosoglutathione (GSNO) are endogenous bronchodilators in human airways. Decreased airway S-nitrosothiol concentrations are associated with asthma. Nitric oxide (NO), a breakdown product of GSNO, is measured in exhaled br

Externí odkaz: https://doaj.org/article/d1a130a4543a4d1bb3d6263a060b364e

Red Blood Cell-Mediated S-Nitrosohemoglobin-Dependent Vasodilation: Lessons Learned from a β-Globin Cys93 Knock-In Mouse

Autor: Jonathan S. Stamler, Rongli Zhang, Richard T. Premont, James D. Reynolds

Publikováno v: Antioxid Redox Signal

Significance: Red blood cell (RBC)-mediated vasodilation plays an important role in oxygen delivery. This occurs through hemoglobin actions, at least in significant part, to convert heme-bound nitric oxide (NO) (in tense [T]/deoxygenated-state hemogl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b7b77d1d7eb0a04c8d48ba71b58a40d
https://doi.org/10.1089/ars.2020.8153

P7C3-A20 treatment one year after TBI in mice repairs the blood–brain barrier, arrests chronic neurodegeneration, and restores cognition

Autor: Kathryn Franke, Terry C. Yin, Josie L. Emery, Min-Kyoo Shin, Sarah Barker, Xudong Liao, Danyel R. Crosby, Yeojung Koh, Kalyani Chaubey, Rachel Schroeder, James D. Reynolds, Hisashi Fujioka, Matthew M. Harper, Mukesh K. Jain, Andrew A. Pieper, Xinmiao Tang, Matasha Dhar, Emiko Miller, Edwin Vázquez-Rosa, Coral J. Cintrón-Pérez

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance Chronic neurodegeneration, a major cause of the long-term disabilities that afflict survivors of traumatic brain injury (TBI), is linked to an increased risk for late-life neurodegenerative disorders, including Alzheimer’s disease, Par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f041042dfc5a720aa0c91643b314fe
http://europepmc.org/articles/PMC7959512

Single‐Contact, Four‐Terminal Microelectromechanical Relay for Efficient Digital Logic

Autor: James D. Reynolds, Sunil Rana, Elliott Worsey, Qi Tang, Mukesh K. Kulsreshath, Harold M. H. Chong, Dinesh Pamunuwa

Publikováno v: Advanced Electronic Materials
Reynolds, J D, Rana, S, Worsey, E, Tang, Q, Kulsreshath, M K, Chong, H & Pamunuwa, I D B 2022, ' Single-contact, four-terminal microelectromechanical relay for efficient digital logic ', Advanced Electronic Materials . https://doi.org/10.1002/aelm.202200584

Nano and microelectromechanical relays can be used in lieu of transistors to build digital integrated circuits that can operate with zero leakage current at high operating temperatures and radiation levels. Four-terminal (4-T) relays facilitate effic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e08d02ac9eca1fb8a8d06d6e4718873e