Zobrazeno 1 - 10
of 89
pro vyhledávání: '"James D. Orth"'
Autor:
Timothy J. Mitchison, Frank T. Zenke, Claudia Wilm, Christiane Amendt, Clement T. Loy, Jade Shi, Yangzhong Tang, James D. Orth
Supplementary Fig. S1 from Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0595d9ccc193c5c4dd6436ba0d3685f7
https://doi.org/10.1158/1535-7163.22483554
https://doi.org/10.1158/1535-7163.22483554
Autor:
Jennifer R. Diamond, Todd M. Pitts, S. Gail Eckhardt, Stephen Leong, Wells A. Messersmith, Daniel L. Gustafson, Kyrie L. Lopez, Anna Capasso, John J. Tentler, Jihye Kim, Aik-Choon Tan, Ashley E. Glode, Cindy L. O'Bryant, Bradley R. Corr, Elaine T. Lam, Joshua M. Marcus, Brian Gittleman, James D. Orth, Stacey M. Bagby, Anastasia A. Ionkina, S. Lindsey Davis
Purpose:The purpose of this study was to evaluate the rational combination of TORC1/2 inhibitor TAK-228 and Aurora A kinase inhibitor alisertib in preclinical models of triple-negative breast cancer (TNBC) and to conduct a phase I dose escalation tri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bbe60e4aafcc2a305085aeee3b817d1
https://doi.org/10.1158/1078-0432.c.6529839.v1
https://doi.org/10.1158/1078-0432.c.6529839.v1
Autor:
Timothy J. Mitchison, Frank T. Zenke, Claudia Wilm, Christiane Amendt, Clement T. Loy, Jade Shi, Yangzhong Tang, James D. Orth
Supplementary Methods from Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f4016373736a2af88b93a483de1380
https://doi.org/10.1158/1535-7163.22483524
https://doi.org/10.1158/1535-7163.22483524
Autor:
Timothy J. Mitchison, Frank T. Zenke, Claudia Wilm, Christiane Amendt, Clement T. Loy, Jade Shi, Yangzhong Tang, James D. Orth
Supplementary Table S3 from Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4404bcc724ec46d0dc423beee96d7d8a
https://doi.org/10.1158/1535-7163.22483515
https://doi.org/10.1158/1535-7163.22483515
Autor:
Jennifer R. Diamond, Todd M. Pitts, S. Gail Eckhardt, Stephen Leong, Wells A. Messersmith, Daniel L. Gustafson, Kyrie L. Lopez, Anna Capasso, John J. Tentler, Jihye Kim, Aik-Choon Tan, Ashley E. Glode, Cindy L. O'Bryant, Bradley R. Corr, Elaine T. Lam, Joshua M. Marcus, Brian Gittleman, James D. Orth, Stacey M. Bagby, Anastasia A. Ionkina, S. Lindsey Davis
Pharmacodynamic effects of alisertib and TAK-228 in patient tissue samples
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::917279fd1426214a53aa28b086b5d204
https://doi.org/10.1158/1078-0432.22478058
https://doi.org/10.1158/1078-0432.22478058
Autor:
Timothy J. Mitchison, Frank T. Zenke, Claudia Wilm, Christiane Amendt, Clement T. Loy, Jade Shi, Yangzhong Tang, James D. Orth
Kinesin-5 inhibitors (K5I) are promising antimitotic cancer drug candidates. They cause prolonged mitotic arrest and death of cancer cells, but their full range of phenotypic effects in different cell types has been unclear. Using time-lapse microsco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7458dcb870e35eaa46251de3f99e9798
https://doi.org/10.1158/1535-7163.c.6531162
https://doi.org/10.1158/1535-7163.c.6531162
Autor:
Timothy J. Mitchison, Frank T. Zenke, Claudia Wilm, Christiane Amendt, Clement T. Loy, Jade Shi, Yangzhong Tang, James D. Orth
Supplementary Fig. from Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f5b3ed18a9fbe5dab79cee17aedfa7a
https://doi.org/10.1158/1535-7163.22483527.v1
https://doi.org/10.1158/1535-7163.22483527.v1
Autor:
Timothy J. Mitchison, Ralph Weissleder, Peter K. Sorger, Floris Foijer, Rainer H. Kohler, James D. Orth
Supplementary Figure 2 from Analysis of Mitosis and Antimitotic Drug Responses in Tumors by In Vivo Microscopy and Single-Cell Pharmacodynamics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02fff41119102288eebfbd8f11fe2482
https://doi.org/10.1158/0008-5472.22390623.v1
https://doi.org/10.1158/0008-5472.22390623.v1
Autor:
Timothy J. Mitchison, Ralph Weissleder, Peter K. Sorger, Floris Foijer, Rainer H. Kohler, James D. Orth
Supplementary Video 2 from Analysis of Mitosis and Antimitotic Drug Responses in Tumors by In Vivo Microscopy and Single-Cell Pharmacodynamics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f43cd12768fbf05c71b5a76878e3c22
https://doi.org/10.1158/0008-5472.22390605
https://doi.org/10.1158/0008-5472.22390605
Supplementary Figure 1b from Cell Type Variation in Responses to Antimitotic Drugs that Target Microtubules and Kinesin-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2a1c282f1066d344f6099258ae840f
https://doi.org/10.1158/0008-5472.22376249
https://doi.org/10.1158/0008-5472.22376249