Zobrazeno 1 - 10
of 48
pro vyhledávání: '"James D. Moffatt"'
Autor:
Patrick Dawson, James D. Moffatt
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 39:244-252
The long use of ephedrine, amphetamines, cocaine, LSD and more recently 3,4-methylenedioxy-N-methylamphetamine (MDMA; "Ecstasy") allows us to predict with some confidence what cardiovascular risks are likely to be associated with novel psychoactive s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600f87a1350161ab21e2966e154088a9
https://doi.org/10.1016/j.pnpbp.2012.05.003
https://doi.org/10.1016/j.pnpbp.2012.05.003
Autor:
William C. Cole, James D. Moffatt, Friederike Zunke, Iain A. Greenwood, Søren Peter Olesen, Preet S. Chadha, Alison J. Davis, Thomas A. Jepps, Hai-Lei Zhu
Publikováno v:
Hypertension. 59:877-884
KCNQ4-encoded voltage-dependent potassium (Kv7.4) channels are important regulators of vascular tone that are severely compromised in models of hypertension. However, there is no information as to the role of these channels in responses to endogenous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0019c43a2833ed85bcd726ed0c9f251e
https://doi.org/10.1161/hypertensionaha.111.187427
https://doi.org/10.1161/hypertensionaha.111.187427
Autor:
William C. Cole, Iain A. Greenwood, Susumu Ohya, James D. Moffatt, Xi Zoë Zhong, Søren Peter Olesen, Maksym I. Harhun
Publikováno v:
The Journal of Physiology. 588:3277-3293
KCNQ gene expression was previously shown in various rodent blood vessels, where the products of KCNQ4 and KCNQ5, Kv7.4 and Kv7.5 potassium channel subunits, respectively, have an influence on vascular reactivity. The aim of this study was to determi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1155408b8508eb62e63851ba1663ab5
https://doi.org/10.1113/jphysiol.2010.192823
https://doi.org/10.1113/jphysiol.2010.192823
Autor:
James D. Moffatt
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 375:1-9
Proteinase-activated receptors (PARs) are G-protein-coupled receptors that convert specific extracellular proteolytic activity into intracellular signals, and have been suggested to play diverse roles in the body. In this review, evidence for the rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8ad785914e0378dce90e81f5ee5c39d
https://doi.org/10.1007/s00210-007-0139-9
https://doi.org/10.1007/s00210-007-0139-9
Protease-Activated Receptor-2 Peptides Activate Neurokinin-1 Receptors in the Mouse Isolated Trachea
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 317:598-605
Protective roles for protease-activated receptor-2 (PAR(2)) in the airways including activation of epithelial chloride (Cl(-)) secretion are based on the use of presumably PAR(2)-selective peptide agonists. To determine whether PAR(2) peptide-activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42085ef9a0e15d0793fc6eebadbbde88
https://doi.org/10.1124/jpet.105.097121
https://doi.org/10.1124/jpet.105.097121
Publikováno v:
British Journal of Pharmacology. 144:1011-1016
1 The effect of adenosine on transepithelial ion transport was investigated in isolated preparations of murine trachea mounted in Ussing chambers. The possible regulation of adenosine receptors in an established model of allergic airway inflammation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a02079cd3d364240947fe443eba8ecc
https://doi.org/10.1038/sj.bjp.0706133
https://doi.org/10.1038/sj.bjp.0706133
Publikováno v:
British Journal of Pharmacology. 143:269-275
Active thrombin is found in the airways of patients with a variety of inflammatory lung diseases. However, whether thrombin contributes to the pathologies of these diseases is unknown, although thrombin is a potent inflammatory mediator in other orga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a46d66b726bda6eb046f7e905740695b
https://doi.org/10.1038/sj.bjp.0705926
https://doi.org/10.1038/sj.bjp.0705926
Publikováno v:
Current Opinion in Pharmacology. 4:221-229
Proteinase-activated receptors (PARs) are novel G-protein-coupled receptors activated by serine and other proteinases to induce changes in cellular function. There is extensive evidence that PARs are expressed in the airways in a variety of cell type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caef548a8b596f3e041c04a8d11636e4
https://doi.org/10.1016/j.coph.2004.01.012
https://doi.org/10.1016/j.coph.2004.01.012
Publikováno v:
British Journal of Pharmacology. 141:1159-1166
The 5-HT receptor subtype that mediates bronchocontraction and the involvement of neuronal and non-neuronal acetylcholine was assessed in murine isolated tracheae. Atropine (1–10 nM) caused a rightward shift of the methacholine concentration–effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b75738835c9076da919102158eb5ecc
https://doi.org/10.1038/sj.bjp.0705720
https://doi.org/10.1038/sj.bjp.0705720
Publikováno v:
British Journal of Pharmacology. 136:492-501
Protease-activated receptor (PAR)-mediated vascular relaxations have been compared in coronary arteries of different diameters isolated from both humans and pigs. Thrombin, trypsin, and the PAR1-activating peptide, TFLLR, all caused concentration-dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc4275892518c822aa2804848de2373a
https://doi.org/10.1038/sj.bjp.0704714
https://doi.org/10.1038/sj.bjp.0704714