Zobrazeno 1 - 10
of 31
pro vyhledávání: '"James D. Irvin"'
Publikováno v:
Biochemical and Biophysical Research Communications. 275:549-552
Pokeweed antiviral protein II (PAP-II) is a naturally occurring protein isolated from early summer leaves of the pokeweed plant (Phytolacca americana). PAP-II belongs to a family of ribosome-inactivating proteins which catalytically deadenylate ribos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e555390abbd7d4b395970ba76e7cd47d
https://doi.org/10.1006/bbrc.2000.3329
https://doi.org/10.1006/bbrc.2000.3329
Publikováno v:
Biochemical and Biophysical Research Communications. 260:453-458
Pokeweed antiviral protein (PAP) is a naturally occurring broad-spectrum antiviral agent with potent anti-human immunodeficiency virus (HIV)-1 activity by an as yet undeciphered molecular mechanism. In the present study, we sought to determine if PAP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd9729d81106b5f30ccc4686c38b92f9
https://doi.org/10.1006/bbrc.1999.0922
https://doi.org/10.1006/bbrc.1999.0922
Autor:
Lisa M. Chelstrom, Roland Gunther, James D. Irvin, Bradley Johnson, Fatih M. Uckun, Dorothea E. Myers, Heather R. Wendorf, Kristi Covalciuc, Dina Clementson, E Schneider
Publikováno v:
Leukemia & Lymphoma. 22:61-70
The investigational biotherapeutic agent, B43(anti-CD19)-pokeweed antiviral protein (PAP) immunotoxin, has shown substantial anti-leukemic activity in SCID mouse models of human B-lineage leukemia and lymphoma. In this report, we describe the results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4efd86e20d6adde265996c5b6bc7e00d
https://doi.org/10.3109/10428199609051729
https://doi.org/10.3109/10428199609051729
Autor:
Dorothea E. Myers, Fatih M. Uckun, James D. Irvin, Eric Masson, Yuri Yanishevski, William E. Evans
Publikováno v:
Leukemia & Lymphoma. 18:93-102
Standard immunotoxin production procedures using whole IgG as the MoAb moiety yield a heterogeneous mixture of 180 kDa, 210 kDa, and 240 kDa immunotoxin species with 1 to 1, 1 to 2, and 1 to 3 MoAb to toxin ratios. This heterogeneity makes it impossi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5a56b5b8cd90edc938d7da296c447f
https://doi.org/10.3109/10428199509064928
https://doi.org/10.3109/10428199509064928
Publikováno v:
The Plant Journal. 5:173-183
Pokeweed antiviral protein (PAP) and other ribosome-inactivating proteins (RIPs) had previously been thought to be incapable of attacking conspecific ribosomes, thus having no effect on endogenous processes. This assertion conflicts with a model for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d92d051df786e9703a44894b628a20e
https://doi.org/10.1046/j.1365-313x.1994.05020173.x
https://doi.org/10.1046/j.1365-313x.1994.05020173.x
Autor:
L.L. Houston, Virginia M. Kuebelbeck, Dorothea E. Myers, Fatih M. Uckun, Dale Finnegan, Lisa M. Chelstrom, James D. Irvin
Publikováno v:
Leukemia & Lymphoma. 9:459-476
We have successfully constructed highly potent and selective anti-CD19 PAP immunotoxins using each of the three crosslinking agents, SPDP, LC-SPDP, or SMPT, to generate an intermolecular bridge between the B43 MoAb and PAP toxin moieties. These immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ba895ba5d4c3243cf8175d30c663c1
https://doi.org/10.3109/10428199309145753
https://doi.org/10.3109/10428199309145753
Publikováno v:
Antimicrobial Agents and Chemotherapy. 34:2034-2037
Infection of HeLa cells with poliovirus results in cell permeabilization to pokeweed antiviral protein. Cell permeabilization was dependent on the integrity of virus capsid proteins and directly proportional to the multiplicity of infection. This stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f32a620a2d5030350cfa41f4c2aef686
https://doi.org/10.1128/aac.34.10.2034
https://doi.org/10.1128/aac.34.10.2034
Publikováno v:
Journal of molecular biology. 233(4)
The pokeweed antiviral protein (PAP), isolated from the leaves of Phytolacca americana, is one of a family of plant and bacterial ribosome-inhibiting proteins (RIPs) which act as specific N-glycosidases on rRNA. Here we report the three-dimensional s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b26e9edbf456138643bb18812585f33
https://pubmed.ncbi.nlm.nih.gov/8411176
https://pubmed.ncbi.nlm.nih.gov/8411176
Autor:
James D. Irvin, Fatih M. Uckun
Publikováno v:
Pharmacologytherapeutics. 55(3)
Pokeweed antiviral protein (PAP) is a ribosome-inactivating protein (RIP) that inactivates ribosomes by the removal of a single adenine from ribosomal RNA. The studies summarized in our review concern the nature and application of this novel therapeu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcff03cc8c881249c49680c6010fd0b4
https://pubmed.ncbi.nlm.nih.gov/1492120
https://pubmed.ncbi.nlm.nih.gov/1492120
Publikováno v:
Journal of immunological methods. 136(2)
We describe a standardized method for the preparation and purification of a potent immunotoxin against B-lineage leukemia/lymphoma cells, constructed with the ribosome inhibitory single chain plant toxin pokeweed antiviral protein (PAP) and a murine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7db0065c5d5beb23c98c9ec7aff2400
https://pubmed.ncbi.nlm.nih.gov/1705571
https://pubmed.ncbi.nlm.nih.gov/1705571