Zobrazeno 1 - 10
of 71
pro vyhledávání: '"James D. Hoeschele"'
Autor:
Alessandra Barbanente, Paride Papadia, Anna Maria Di Cosola, Concetta Pacifico, Giovanni Natile, James D. Hoeschele, Nicola Margiotta
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7392 (2024)
It is generally accepted that adjacent guanine residues in DNA are the primary target for platinum antitumor drugs and that differences in the conformations of the Pt-DNA adducts can play a role in their antitumor activity. In this study, we investig
Externí odkaz:
https://doaj.org/article/45a93cff35024275bb09f22c2f099c6a
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 7917 (2023)
The year 2023 marks the 45th year since FDA approval of cisplatin as an anticancer drug, and, at present, it is widely used against a spectrum of human tumors, including early-stage ovarian cancer, non-small cell lung cancer (typically developed by s
Externí odkaz:
https://doaj.org/article/d4433c2a27c7494ca0c5153f53e13971
Autor:
Alessandra Barbanente, Valentina Gandin, Cecilia Ceresa, Cristina Marzano, Nicoletta Ditaranto, James D. Hoeschele, Giovanni Natile, Fabio Arnesano, Concetta Pacifico, Francesco P. Intini, Nicola Margiotta
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7081 (2022)
Kiteplatin, [PtCl2(cis-1,4-DACH)] (DACH = diaminocyclohexane), contains an isomeric form of the oxaliplatin diamine ligand trans-1R,2R-DACH and has been proposed as a valuable drug candidate against cisplatin- and oxaliplatin-resistant tumors, in par
Externí odkaz:
https://doaj.org/article/a69e6faa8c724f5cb83e469878a82dce
Autor:
Alessandra Barbanente, Rosa Maria Iacobazzi, Amalia Azzariti, James D. Hoeschele, Nunzio Denora, Paride Papadia, Concetta Pacifico, Giovanni Natile, Nicola Margiotta
Publikováno v:
Molecules, Vol 26, Iss 11, p 3417 (2021)
Two new Pt(II)-pyrophosphato complexes containing the carrier ligands cis-1,3-diaminocyclohexane (cis-1,3-DACH) and trans-1,2-diamine-4-cyclohexene (1,2-DACHEX), variants of the 1R,2R-diaminocyclohexane ligand present in the clinically used Pt-drug o
Externí odkaz:
https://doaj.org/article/d668157a10c34332adb21442a041f6b2
Autor:
Paride Papadia, Katia Micoli, Alessandra Barbanente, Nicoletta Ditaranto, James D. Hoeschele, Giovanni Natile, Cristina Marzano, Valentina Gandin, Nicola Margiotta
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7, p 2325 (2020)
Six platinum(IV) compounds derived from an oxaliplatin analogue containing the unsaturated cyclic diamine trans-1,2-diamino-4-cyclohexene (DACHEX), in place of the 1,2-diaminocyclohexane, and a range of axial ligands, were synthesized and characteriz
Externí odkaz:
https://doaj.org/article/d4dce34ce0c24bd6aff14f07a7c78fa5
Autor:
Salvatore Savino, Cristina Marzano, Valentina Gandin, James D. Hoeschele, Giovanni Natile, Nicola Margiotta
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 7, p 2050 (2018)
Platinum(II) drugs are activated intracellularly by aquation of the leaving groups and then bind to DNA, forming DNA adducts capable to activate various signal-transduction pathways. Mostly explored in recent years are Pt(IV) complexes which allow th
Externí odkaz:
https://doaj.org/article/58b89fa1db5c42d9888547feb050a9f0
Autor:
Paride Papadia, Fabrizio Barozzi, James D. Hoeschele, Gabriella Piro, Nicola Margiotta, Gian-Pietro Di Sansebastiano
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 2, p 306 (2017)
The immediate visual comparison of platinum chemotherapeutics’ effects in eukaryotic cells using accessible plant models of transgenic Arabidopsis thaliana is reported. The leading anticancer drug cisplatin, a third generation drug used for colon c
Externí odkaz:
https://doaj.org/article/a2710aef019b418b826bce041d041360
Autor:
Michael M. Gottesman, James D. Hoeschele, Ian S. Goldlust, John R. Lloyd, James P. Madigan, Tobie D. Lee, Ki-Eun Chang, Katherine A. Telma, Matthew D. Hall
PDF file - 65KB, Peaks observed for ESI+ mass spectra of Pt complexes dissolved in DMSO, associated with Pt-DMSO adducts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb45703cd90e0fdb88cd5d7bd05ddcc9
https://doi.org/10.1158/0008-5472.22402955.v1
https://doi.org/10.1158/0008-5472.22402955.v1
Autor:
Michael M. Gottesman, James D. Hoeschele, Ian S. Goldlust, John R. Lloyd, James P. Madigan, Tobie D. Lee, Ki-Eun Chang, Katherine A. Telma, Matthew D. Hall
PDF file - 1000KB, Scheme demonstrating the aquation of cisplatin in water, and prevention when stabilized in high chloride solution.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d23e00c3ae210c2ce7bc548a06e124
https://doi.org/10.1158/0008-5472.22402958.v1
https://doi.org/10.1158/0008-5472.22402958.v1
Autor:
Michael M. Gottesman, James D. Hoeschele, Ian S. Goldlust, John R. Lloyd, James P. Madigan, Tobie D. Lee, Ki-Eun Chang, Katherine A. Telma, Matthew D. Hall
XLS file - 106KB, Use of solvent for assessing cytotoxicity of platinum complexes in the journal Molecular Cancer Therapeutics (S1). Use of solvent for assessing cytotoxicity of platinum complexes in the journal Public Library of Science (PLoS)(S2).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21322168c092cbc3048fa7f966dc79bc
https://doi.org/10.1158/0008-5472.22402952
https://doi.org/10.1158/0008-5472.22402952