Zobrazeno 1 - 10
of 40
pro vyhledávání: '"James D. Hirsch"'
Autor:
Mary J. Savage, James D. Hirsch, Stephen P. Trusko, Yin-Guo Lin, Diane M. Lang, Dorothy G. Flood, Richard W. Scott, David Howland
Publikováno v:
Neurobiology of Aging. 30:1078-1090
Many transgenic mouse models of Alzheimer's disease (AD) that deposit amyloid (Abeta) have been produced, but development of an Abeta-depositing rat model has not been successful. Here, we describe a rat model with extracellular fibrillar Abeta depos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b1d35644ade0577ee0c1539bd2fcf1
https://doi.org/10.1016/j.neurobiolaging.2007.10.006
https://doi.org/10.1016/j.neurobiolaging.2007.10.006
Autor:
Stephen P. Trusko, Meyer Sl, James D. Hirsch, Richard W. Scott, Knight E, Diane M. Lang, Forbes Me
Publikováno v:
Journal of Neurochemistry. 62:825-833
Bioactive brain-derived neurotrophic factor (BDNF) and neurotrophin-3 were produced using the baculovirus expression system and purified to homogeneity using ion-exchange and reversed-phase chromatography. Yields of purified neurotrophin-3 (300-500 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c4922fda303c236246c1df29550c9ba
https://doi.org/10.1046/j.1471-4159.1994.62030825.x
https://doi.org/10.1046/j.1471-4159.1994.62030825.x
Autor:
Diane R. Gray, Anca Rothe, Stephen T. Yue, Judith E. Berlier, Richard P. Haugland, James D. Hirsch, Joseph M. Beechem, Jixiang Liu, Wesley S. Chang, Rosaria P. Haugland, Gayle Buller, William G. Telford, Ching-Ying Cheung, Jolene Bradford, Brian Filanoski
Publikováno v:
Journal of Histochemistry & Cytochemistry. 51:1699-1712
Amine-reactive N-hydroxysuccinimidyl esters of Alexa Fluor fluorescent dyes with principal absorption maxima at about 555 nm, 633 nm, 647 nm, 660 nm, 680 nm, 700 nm, and 750 nm were conjugated to antibodies and other selected proteins. These conjugat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8457aa7ad673ef67771c673871159180
https://doi.org/10.1177/002215540305101214
https://doi.org/10.1177/002215540305101214
Autor:
Richard P. Haugland, James D. Hirsch, Leila Eslamizar, Brian Filanoski, Joseph M. Beechem, Rosaria P. Haugland, Nabi Malekzadeh
Publikováno v:
Analytical Biochemistry. 308:343-357
The high-affinity binding of biotin to avidin, streptavidin, and related proteins has been exploited for decades. However, a disadvantage of the biotin/biotin-binding protein interaction is that it is essentially irreversible under physiological cond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09efa4e7d396f463d4ac72bf94f3cf5f
https://doi.org/10.1016/s0003-2697(02)00201-4
https://doi.org/10.1016/s0003-2697(02)00201-4
Hindlimb Motor Neurons Require Cu/Zn Superoxide Dismutase for Maintenance of Neuromuscular Junctions
Autor:
Eric K. Hoffman, Andrew G. Reaume, Yin-Guo Lin, Karen S. Dorfman, Richard W. Scott, Dorothy G. Flood, John A. Gruner, James D. Hirsch
Publikováno v:
The American Journal of Pathology. 155:663-672
The role of oxidative damage in neurodegenerative disease was investigated in mice lacking cytoplasmic Cu/Zn superoxide dismutase (SOD), created by deletion of the SOD1 gene ( SOD1 /− ). SOD1 −/− mice developed a chronic peripheral hindlimb axo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c38af02e2e4f154d20d9d43643fd6ef4
https://doi.org/10.1016/s0002-9440(10)65162-0
https://doi.org/10.1016/s0002-9440(10)65162-0
Autor:
Robert Siman, Richard W. Scott, James D. Hirsch, David Howland, Barry D. Greenberg, Mary J. Savage, Andrew G. Reaume, Dorothy G. Flood, Noboyu Maeda, Diane M. Lang, Stephen P. Trusko
Publikováno v:
Journal of Biological Chemistry. 273:16576-16582
The effects of dietary cholesterol on brain amyloid precursor protein (APP) processing were examined using an APP gene-targeted mouse, genetically humanized in the amyloid beta-peptide (Abeta) domain and expressing the Swedish familial Alzheimer's di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0560588341578a0a90569fc480690b9
https://doi.org/10.1074/jbc.273.26.16576
https://doi.org/10.1074/jbc.273.26.16576
Autor:
James D. Hirsch, Rosaria P. Haugland
Publikováno v:
Immunochemical Protocols ISBN: 9781588292742
Antibodies can be conjugated to biotin by a number of chemical means. They can then be used in immunochemical procedures in conjunction with secondary reagents coupled to biotin-binding protein proteins such as avidin.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4ef21a06c83891d6285ddfa38ed6faa
https://doi.org/10.1385/1-59259-873-0:135
https://doi.org/10.1385/1-59259-873-0:135
Autor:
James D, Hirsch, Rosaria P, Haugland
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 295
Antibodies can be conjugated to biotin by a number of chemical means. They can then be used in immunochemical procedures in conjunction with secondary reagents coupled to biotin-binding protein proteins such as avidin.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b3295125a8c3d13a29486b9a25cc041
https://pubmed.ncbi.nlm.nih.gov/15596894
https://pubmed.ncbi.nlm.nih.gov/15596894
Autor:
Robert J. Chorvat, James D. Hirsch, Suzanne Evans Radak, James L. Bloss, Stanley S. Tenen, Bipin N. Desai
Publikováno v:
Journal of Medicinal Chemistry. 26:845-850
A series of oxopyridobenzothiazines (azaphenothiazines) were prepared and evaluated for binding to the benzodiazepine receptor, anticonvulsant activity in the pentylenetetrazole-induced convulsion assay, and, in two cases, ability to increase punishe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65702037fa73874c9c5da87829709518
https://doi.org/10.1021/jm00360a011
https://doi.org/10.1021/jm00360a011
Publikováno v:
Pharmacology Biochemistry and Behavior. 23:681-685
This paper reviews selected aspects of benzodiazepine binding site heterogeneity. These include receptor heterogeneity revealed by biochemical determinations of receptor numbers, autoradiographic localization in histological sections of brain, lesion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7008da8864fe82c6ac9adc5ae60f503b
https://doi.org/10.1016/0091-3057(85)90437-x
https://doi.org/10.1016/0091-3057(85)90437-x