The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling

Autor: Amy A Worth, Rosemary Shoop, Katie Tye, Claire H Feetham, Giuseppe D'Agostino, Garron T Dodd, Frank Reimann, Fiona M Gribble, Emily C Beebe, James D Dunbar, Jesline T Alexander-Chacko, Dana K Sindelar, Tamer Coskun, Paul J Emmerson, Simon M Luckman

Publikováno v: eLife, Vol 9 (2020)

The cytokine, GDF15, is produced in pathological states which cause cellular stress, including cancer. When over expressed, it causes dramatic weight reduction, suggesting a role in disease-related anorexia. Here, we demonstrate that the GDF15 recept

Externí odkaz: https://doaj.org/article/825a4f2bc81540a88d659e35ab6f5327

Discovery, development, and clinical proof of mechanism of LY3463251, a long-acting GDF15 receptor agonist

Autor: Olivier Benichou, Tamer Coskun, Malgorzata D. Gonciarz, Parag Garhyan, Andrew C. Adams, Yu Du, James D. Dunbar, Jennifer A. Martin, Kieren J. Mather, Richard T. Pickard, Vincent L. Reynolds, Deborah A. Robins, Simbarashe P. Zvada, Paul J. Emmerson

Publikováno v: Cell Metabolism. 35:274-286.e10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::baa032b2d63005b53831e6b7ac4e74b3
https://doi.org/10.1016/j.cmet.2022.12.011

The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling

Autor: Tamer Coskun, Claire H. Feetham, Giuseppe D'Agostino, Garron T. Dodd, Amy A. Worth, Frank Reimann, James D. Dunbar, Fiona M. Gribble, Simon M. Luckman, Paul J. Emmerson, Katie Tye, Emily C Beebe, Dana Sindelar, Jesline T. Alexander-Chacko, Rosemary Shoop

Publikováno v: Worth, A A, Shoop, R, Tye, K, Feetham, C H, D'Agostino, G, Dodd, G T, Reimann, F, Gribble, F M, Beebe, E C, Dunbar, J D, Alexander-Chacko, J T, Sindelar, D K, Coskun, T, Emmerson, P J & Luckman, S M 2020, ' The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling ', eLife, vol. 9, e55164, pp. 1-19 . https://doi.org/10.7554/eLife.55164
eLife, Vol 9 (2020)
eLife

The cytokine, GDF15, is produced in pathological states which cause cellular stress, including cancer. When over expressed, it causes dramatic weight reduction, suggesting a role in disease-related anorexia. Here, we demonstrate that the GDF15 recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c36fee4c12ae9aa6d1944526e39affe

Fundamentals of FGF19 & FGF21 action in vitro and in vivo.

Autor: Andrew C Adams, Tamer Coskun, Armando R Irizarry Rovira, Michael A Schneider, David W Raches, Radmila Micanovic, Holly A Bina, James D Dunbar, Alexei Kharitonenkov

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e38438 (2012)

Fibroblast growth factors 19 (FGF19) and 21 (FGF21) have emerged as key regulators of energy metabolism. Several studies have been conducted to understand the mechanism of FGF19 and FGF21 action, however, the data presented has often been inconsisten

Externí odkaz: https://doaj.org/article/83545c5b932f44aa84d465c8ea358ac7

Nutlin3 Blocks Vascular Endothelial Growth Factor Induction by Preventing the Interaction between Hypoxia Inducible Factor 1α and Hdm2

Autor: James D. Dunbar, Robert S. Warren, Mark W. Jackson, Gretchen A. LaRusch, Lindsey D. Mayo, David B. Donner

Publikováno v: Cancer Research. 67:450-454

Hdm2 is elevated in numerous types of malignancies and is thought to impede the function of wild-type p53. Reactivation of p53 by disrupting the association with Hdm2 was the impetus for the development of Nutlin3. Although regulation of p53 has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::978ccbd1cc7a5e488d4643894b71c5f1
https://doi.org/10.1158/0008-5472.can-06-2710