Zobrazeno 1 - 10 of 10 pro vyhledávání: '"James D. Douglas"'
1
Facile synthesis of (Z)-tetracos-5-enoic acid and racemic cis-4-(2-octadecylcyclopropane-1-yl)-butanoic acid
Autor: James D. Douglas, David E. Minnikin, Geoffrey D. Coxon
Publikováno v: Chemistry and Physics of Lipids. 126:49-53
(Z)-tetracos-5-enoic acid and racemic cis-4-(2-octadecylcyclopropane-1-yl)-butanoic acid have been prepared from 1-eicosene by a new facile route. Periodic acid cleavage of the epoxide of 1-eicosene gave nonadecanal which was condensed with 4-carboxy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac9445e7fc973fda2328c714ac54995
https://doi.org/10.1016/s0009-3084(03)00092-6
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2
A Type II Pathway for Fatty Acid Biosynthesis Presents Drug Targets in Plasmodium falciparum
Autor: Michael B. Reed, David E. Minnikin, Alan F. Cowman, Ross F. Waller, Vanessa Su, Stuart A. Ralph, James D. Douglas, Gurdyal S. Besra, Geoffrey I. McFadden
Publikováno v: Antimicrobial Agents and Chemotherapy. 47:297-301
It has long been held that the malaria parasite, Plasmodium sp., is incapable of de novo fatty acid synthesis. This view has recently been overturned with the emergence of data for the presence of a fatty acid biosynthetic pathway in the relict plast
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a4ef3aa8185694f222cf1f8b8bb5e80
https://doi.org/10.1128/aac.47.1.297-301.2003
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4
Thiolactomycin and Related Analogues as Novel Anti-mycobacterial Agents Targeting KasA and KasB Condensing Enzymes inMycobacterium tuberculosis
Autor: James D. Douglas, Caroline B. Morehouse, Laurent Kremer, Lynn G. Dover, David Alland, Gurdyal S. Besra, Alain R. Baulard, Jeremy H. Lakey, William R. Jacobs, Mark R. Guy, David E. Minnikin, Patrick J. Brennan
Publikováno v: Journal of Biological Chemistry. 275:16857-16864
Prevention efforts and control of tuberculosis are seriously hampered by the appearance of multidrug-resistant strains of Mycobacterium tuberculosis, dictating new approaches to the treatment of the disease. Thiolactomycin (TLM) is a unique thiolacto
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ae4b390b58b177ea7e84116a6d4a8a
https://doi.org/10.1074/jbc.m000569200
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5
Antimycobacterial Activities of Isoxyl and New Derivatives through the Inhibition of Mycolic Acid Synthesis
Autor: Benjawan Phetsuksiri, David E. Minnikin, James D. Douglas, Patrick J. Brennan, Alain R. Baulard, Andrea M. Cooper, Gurdyal S. Besra
Publikováno v: Antimicrobial Agents and Chemotherapy. 43:1042-1051
Isoxyl (ISO), a thiourea (thiocarlide; 4,4′-diisoamyloxythiocarbanilide), demonstrated potent activity against Mycobacterium tuberculosis H37Rv (MIC, 2.5 μg/ml), Mycobacterium bovis BCG (MIC, 0.5 μg/ml), Mycobacterium avium (MIC, 2.0 μg/ml), and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a502f81cd5acb53c347be5bf3c570df
https://doi.org/10.1128/aac.43.5.1042
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6
Analogues of thiolactomycin: potential drugs with enhanced anti-mycobacterial activity
Autor: James D, Douglas, Suzanne J, Senior, Caroline, Morehouse, Benjawan, Phetsukiri, Ian B, Campbell, Gurdyal S, Besra, David E, Minnikin
Publikováno v: Microbiology (Reading, England). 148(Pt 10)
Analogues of the antibiotic thiolactomycin (TLM) have been synthesized and have been shown to have enhanced activity against whole cells of Mycobacterium tuberculosis H37Rv and against mycolic acid biosynthesis in cell extracts of Mycobacterium smegm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d6fff6711846a13bea34d7d1d5f1bcaf
https://pubmed.ncbi.nlm.nih.gov/12368443
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